Abstract.
The application of high-resolution multi-step resonance ionization mass spectrometry (RIMS) to the trace determination of the rare earth element gadolinium is described. Utilizing three-step resonant excitation into an autoionizing level, both isobaric and isotopic selectivity of >107 were attained. An overall detection efficiency of ~10–7 and an isotope specific detection limit of 1.5×109 atoms have been demonstrated. When targeting the major isotope 158Gd, this corresponds to a total Gd detection limit of 1.6 pg. Additionally, linear response has been demonstrated over a dynamic range of six orders of magnitude. The method has been used to determine the Gd content in various normal and tumor tissue samples, taken from a laboratory mouse shortly after injection of gadolinium diethylenetriaminepentaacetic acid dimeglumine (Gd-DTPA), which is used as a contrast agent for magnetic resonance imaging (MRI). The RIMS results show Gd concentrations that vary by more than two orders of magnitude (0.07–11.5 µg mL–1) depending on the tissue type. This variability is similar to that observed in MRI scans that depict Gd-DTPA content in the mouse prior to dissection, and illustrates the potential for quantitative trace analysis in microsamples of biomedical materials.
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Blaum, K., Geppert, C., Schreiber, W. et al. Trace determination of gadolinium in biomedical samples by diode laser-based multi-step resonance ionization mass spectrometry. Anal Bioanal Chem 372, 759–765 (2002). https://doi.org/10.1007/s00216-002-1268-0
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DOI: https://doi.org/10.1007/s00216-002-1268-0