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Theoretical Chemistry Accounts

, 138:112 | Cite as

On the impact of a phosphoryl group in the recognition capabilities of 2-aminopyridines toward carboxylic acids

  • Miguel Gallegos
  • Sara Gil-Guerrero
  • A. Fernández-Alarcón
  • Diego Bouzas-Ramos
  • Judith Martín
  • Carmen Concellón
  • Vicente del Amo
  • J. M. Costa
  • R. Mendoza-Meroño
  • S. García-Granda
  • Ángel Martín Pendás
  • Aurora CostalesEmail author
Regular Article
Part of the following topical collections:
  1. 11th Congress on Electronic Structure: Principles and Applications (ESPA-2018)

Abstract

Inspired by natural molecular recognition processes, many research efforts have been routed in recent years toward the design of new host–guest molecular systems based on non-covalent interactions. Within this field, 2-aminopyridines (2APs) have been widely studied due to their tunable spectroscopic response in the presence of carboxylic acids. Herein, we present and analyze a novel family of 2AP core compounds based on 2-phosphorylamidopyridine (2PAP). Linear response time-dependent density functional theory (TD-DFT) has been used to characterize and model several spectroscopic properties of 2PAP. Our results, validated through experiments, show that TD-DFT can provide a reliable description of the electronic excited states of these aromatic systems. In addition, we have also studied the amino–imino tautomerization of 2AP and 2PAP in light of TD-DFT tools. We show that the presence of a carboxylic acid has a catalytic effect on the tautomerization reaction, which otherwise does not occur spontaneously at room temperature. These results suggest that this low-cost computational approach can be applied to more complex organic systems derived from 2-aminopyridine, paving the way for the development of potentially useful sensing materials and organic species for molecular recognition.

Keywords

Molecular recognition Amino–imino tautomerization Fluorescence 2-aminopyridines 

Notes

Acknowledgements

We acknowledge financial support form Spanish MINECO/FEDER, Grants CTQ2015-65790-P and CTQ2016-76829-R and Principado de Asturias Government Grant FC-GRUPIN-IDI/2018/000117. C. C. expresses her gratitude to MINECO for the award of “Ramón y Cajal” contract (RYC-2014-16021). AFA thanks CONACyT/México for his scholarship 436154. We also thank Dr. P. Braña for fruitful discussions.

Supplementary material

214_2019_2496_MOESM1_ESM.pdf (2 mb)
Supplementary material 1 (pdf 2086 KB)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Miguel Gallegos
    • 1
  • Sara Gil-Guerrero
    • 2
  • A. Fernández-Alarcón
    • 1
  • Diego Bouzas-Ramos
    • 1
  • Judith Martín
    • 3
  • Carmen Concellón
    • 3
  • Vicente del Amo
    • 3
  • J. M. Costa
    • 1
  • R. Mendoza-Meroño
    • 1
  • S. García-Granda
    • 1
  • Ángel Martín Pendás
    • 1
  • Aurora Costales
    • 1
    Email author
  1. 1.Department of Analytical and Physical ChemistryUniversity of OviedoOviedoSpain
  2. 2.Department of Physical ChemistryUniversity of VigoVigoSpain
  3. 3.Department of Inorganic and Organic ChemistryUniversity of OviedoOviedoSpain

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