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Why choose 9-cis retinal for therapy of congenital stationary night blindness caused by G90D rhodopsin?

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Abstract

The thermal stability and thermal activity of four G90D rhodopsin isomer models were investigated by QM/MM method. The results implied that one pathological mechanism of congenital stationary night blindness caused by G90D mutation is the low thermal isomerization barrier of G90D rhodopsin binding with 11-cis retinal, not just the lacking of natural salt bridge. 9-cis retinal binding with G90D rhodopsin opsin could increase the thermal stability and minimize the thermal isomerization of G90D rhodopsin mutant. Therefore, 9-cis retinal was suggested to be used in potential treatments for congenital stationary night blindness caused by G90D mutation.

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Acknowledgements

This work was supported by a Grant from the National Natural Science Foundation of China (21403225 and 21103167).

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  1. State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, Liaoning, People’s Republic of China

    Peng Xie & Yan Zhang

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  1. Peng Xie
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Correspondence to Yan Zhang.

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Xie, P., Zhang, Y. Why choose 9-cis retinal for therapy of congenital stationary night blindness caused by G90D rhodopsin?. Theor Chem Acc 136, 12 (2017). https://doi.org/10.1007/s00214-016-2039-x

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