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Raman spectroscopy study of breast disease

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Abstract

The aim of this study was to evaluate the vibrational modes of malignant and benign breast tissues with the following diagnosis: fibroadenoma, invasive ductal carcinoma, ductal carcinoma in situ, and fibrocystic condition. Quadratic discriminate analysis, a multivariate statistical method of analysis, showed 98.5% separation between normal and altered tissue. Significant changes were observed at the lower Raman shift for altered tissue. For a better understanding of the spectral differences, a biochemical interpretation was also performed in terms of the reduction and oxidation processes in the cell environment which could be associated with an inflammatory reaction.

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Abbreviations

BC:

Breast cancer

RS:

Raman spectroscopy

FBC:

Fibrocystic breast conditions

FD:

Fibroadenoma

DCIS:

Ductal carcinoma in situ

IDC:

Invasive ductal carcinoma

PCA:

Principal component analysis

LDA:

Linear discriminant analysis

QDA:

Quadratic correlation analysis

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Acknowledgments

The author would like to thank the pathologists Cíntia Lopes, Jerso Menegasi, and Rosane Aguiar for supporting the histopathologic analysis. The author also thanks the patients for permitting this research. A word of gratitude is due to FAPESP and CNPq for their financial support on Projects 0114384-8 and 301362/2006-8, respectively.

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Authors and Affiliations

  1. Laboratory of Biomedical Vibrational Spectroscopy, Institute of Research and Development, IP&D, Universidade do Vale do Paraíba, UniVap, Shishima Hifumi Avenue, 2911, São José dos Campos, São Paulo, 12244-000, Brazil

    Marcelo Moreno, Leandro Raniero, Emília Ângelo Loschiavo Arisawa, Ana Maria do Espírito Santo, Edson Aparecido Pereira dos Santos, Renata Andrade Bitar & Airton Abrahão Martin

  2. Medical School, Universidade Comunitária Regional de Chapecó, Unochapecó, Senador Attílio Fontana Avenue, 591-E, Chapecó, Santa Catarina, 89809-000, Brazil

    Marcelo Moreno

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  1. Marcelo Moreno
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  2. Leandro Raniero
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  3. Emília Ângelo Loschiavo Arisawa
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  4. Ana Maria do Espírito Santo
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  5. Edson Aparecido Pereira dos Santos
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  6. Renata Andrade Bitar
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  7. Airton Abrahão Martin
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Corresponding author

Correspondence to Airton Abrahão Martin.

Additional information

Dedicated to Professor Sandor Suhai on the occasion of his 65th birthday and published as part of the Suhai Festschrift Issue.

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Moreno, M., Raniero, L., Arisawa, E.Â.L. et al. Raman spectroscopy study of breast disease. Theor Chem Acc 125, 329–334 (2010). https://doi.org/10.1007/s00214-009-0698-6

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