, Volume 158, Issue 2, pp 114–119

5-HT6 receptor antagonists enhance retention of a water maze task in the rat

  •  D. Rogers
  •  J. Hagan
Original Investigation

DOI: 10.1007/s002130100840

Cite this article as:
Rogers, D. & Hagan, J. Psychopharmacology (2001) 158: 114. doi:10.1007/s002130100840


Rationale: 5-HT6 receptors are predominantly located in the brain and may be involved in cognitive processes. The aim of this study was to assess the effects of two potent and selective 5-HT6 receptor antagonists, SB-271046-A and SB-357134-A, on learning and memory in the rat. Methods: Spatial learning and memory was assessed by testing the effects of SB-271046-A and SB-357134-A on acquisition and retention of a water maze task. Results: In the water maze, administration of SB-271046-A or SB-357134-A (3 or 10 mg/kg) had no effect on learning per se. At 10 mg/kg, however, both compounds produced a significant improvement in retention of a previously learned platform position when tested 7 days after training. By contrast, the acetylcholinesterase inhibitor, Aricept (donepezil, 0.1, 0.3 mg/kg PO) had no effect in this task. Conclusions: This study demonstrates that systemic administration of SB-271046-A and SB-357134-A produces improvements in retention of a water maze task in the rat. These data indicate that 5-HT6 receptor antagonism may be involved in cognitive function.

5-HT6 receptor SB-271046-A SB-357134-A Aricept Water maze Learning and memory Rat 

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  •  D. Rogers
    • 1
  •  J. Hagan
    • 1
  1. 1.Neuroscience Research, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AW, UK

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