Psychopharmacology

, Volume 145, Issue 3, pp 342–350 | Cite as

Electroencephalographic effects of intravenous nicotine – a dose-response study

  • M. Lindgren
  • Lars Molander
  • Charlotte Verbaan
  • Erik Lunell
  • Ingmar Rosén
Original Investigation

Abstract 

Rationale: It has often been demonstrated that both tobacco abstinence and nicotine have effects on the EEG power spectrum and components of the event-related potentials. In contrast, few attempts have been made to establish the dose-response relationship between nicotine and EEG parameters. Objectives: The aim of this study was to investigate the dose-response relationship for EEG and auditory oddball P300 parameters over a wide range of intravenously infused nicotine doses. Method: Fourteen regular smokers who had abstained from nicotine for at least 12 h were given intravenous infusions of 0, 3.5, 7, 14 and 28 µg/kg nicotine over 10 min in a single-blind randomised cross-over design. Parallel recordings of spontaneous EEG, auditory P300 and heart rate, as well as venous blood sampling were made before, during and after nicotine administration. Results: Linear dose-related decreases of delta and theta power were found, along with increases in alpha2 power and alpha peak frequency. Alpha1, beta and P300 parameters were unaffected. Conclusion: Our results are consistent with nicotine-dependent changes in EEG measures indicative of arousal.

Key words EEG P300 Intravenous Nicotine Dose-response 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • M. Lindgren
    • 1
  • Lars Molander
    • 2
  • Charlotte Verbaan
    • 2
  • Erik Lunell
    • 2
  • Ingmar Rosén
    • 1
  1. 1.Division of Clinical Neurophysiology, Department of Clinical Neuroscience, University Hospital, S-221 85 Lund, Sweden e-mail: Magnus.Lindgren@knflab.lu.se Fax: +46-46-14-65-28SE
  2. 2.Department of Clinical Pharmacology, Pharmacia and Upjohn Consumer Healthcare, Lund, SwedenSE

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