Abstract
In this study, the influences of GABAB agents on antidepressant-induced antinociception in the mouse formalin test have been investigated. The GABAB receptor agonist baclofen (2.5, 5 and 10 mg/kg) induced a dose-dependent antinociception in the second phase of the formalin test. This response was inhibited by the GABAB receptor antagonist, CGP35348 [P-(3-aminopropyl)-p-diethoxymethyl-phosphinic acid], in a dose-dependent manner. The antagonist by itself also induced antinociception. Single administration of the antidepressants citalopram (10, 20, 40 and 80 mg/kg), desipramine (20, 40, 80 mg/kg) or imipramine (10, 20 and 40 mg/kg) also induced antinociception in both phases of the formalin test. CGP35348 (100 and 200 mg/kg) pretreatment reduced the response induced by the tricyclic antidepressants. A combination of baclofen with the tricyclic antidepressant did not potentiate antinociception induced by antidepressants, but a decrease in the response induced by higher dose of baclofen was shown. It is concluded that GABA mechanism(s) may modulate the antidepressant-induced antinociception.
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Received: 3 August 1998/Final version: 28 September 1998
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Sabetkasai, M., Khansefid, N., Yahyavi, SH. et al. Baclofen and antidepressant – induced antinociception in formalin test: possible GABAB mechanism involvement. Psychopharmacology 142, 426–431 (1999). https://doi.org/10.1007/s002130050909
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DOI: https://doi.org/10.1007/s002130050909