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Acute tryptophan depletion attenuates the prolactin response to d-fenfluramine challenge in healthy human subjects

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Abstract

Prolactin responses to d-fenfluramine (d-FEN) Challenge (0.5 mg/kg PO) were examined after pretreatment with and without acute tryptophan depletion (ATD) in six physically healthy male volunteers. Compared to pretreatment with SHAM-ATD, ATD pretreatment attenuated the PRL response to d-FEN Challenge in all subjects. These data suggest that PRL responses to d-FEN challenge reflect to a substantial degree the activity of newly synthesized 5-HT.

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Authors and Affiliations

  1. Clinical Neuroscience Research Unit, Department of Psychiatry, MCP Hahnemann School of Medicine, 3200 Henry Avenue, Philadelphia, PA 19129, USA Fax: +1-215-842-4321, , , , , , US

    E. F. Coccaro & Richard J. Kavoussi

  2. Analytical Psychopharmacology Laboratory, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA, , , , , , US

    Thomas B. Cooper

  3. Neuroendocrine Research Laboratory, Department of Psychiatry, University of California, San Diego, California, USA, , , , , , US

    Richard Hauger

Authors
  1. E. F. Coccaro
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  2. Richard J. Kavoussi
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  3. Thomas B. Cooper
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  4. Richard Hauger
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Received: 12 June 1997 /Final version: 19 December 1997

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Coccaro, E., Kavoussi, R., Cooper, T. et al. Acute tryptophan depletion attenuates the prolactin response to d-fenfluramine challenge in healthy human subjects. Psychopharmacology 138, 9–15 (1998). https://doi.org/10.1007/s002130050639

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  • DOI: https://doi.org/10.1007/s002130050639

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