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Psychopharmacology

, Volume 136, Issue 3, pp 243–246 | Cite as

Antidepressant-associated mania: a study of anxiety disorders patients

  • D. Levy
  • R. Kimhi
  • Y. Barak
  • A. Aviv
  • A. Elizur
ORIGINAL INVESTIGATION

Abstract

Antidepressants are related to the emergence of manic and hypomanic episodes in mood disorder patients. This study examined whether antidepressant-associated manic states are also present in anxiety disorder patients, so that this phenomenon may be defined as a side-effect. A total of 167 consecutive patients at a specialized outpatient clinic, suffering from anxiety disorders and treated by antidepressants, were assessed in a blind, retrospective chart review. Five patients (2.99%) were identified as having suffered an episode of antidepressant-associated mania within 3 months of initiation of treatment. All were females and all had an axis II diagnosis of a cluster B personality disorder. Antidepressant-associated mania appears to be related to risk factors such as personality disorder, even in non-mood disorder patients, tentatively suggesting that it is not simply an adverse event but rather a reflection of an underlying psychopathology.

Key words Antidepressant-associated mania Anxiety disorder 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • D. Levy
    • 1
  • R. Kimhi
    • 1
  • Y. Barak
    • 1
  • A. Aviv
    • 1
  • A. Elizur
    • 1
  1. 1.The Y. Abarbanel Mental Health Center, Bat-Yam, (Affiliated with the Sackler School of Medicine, Tel-Aviv University), 15, Keren-Kayemet Blv., Bat-Yam 59100, Israel Fax: +972-3-5552738IL

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