Psychopharmacology

, Volume 133, Issue 3, pp 309–312 | Cite as

5-HT2C receptor activation decreases appetite and body weight in obese subjects

  • P. A. Sargent
  • A. L. Sharpley
  • C. Williams
  • E. M. Goodall
  • P. J. Cowen
RAPID COMMUNICATION

Abstract

We studied the effect of 2 weeks administration of the 5-HT2C receptor agonist, m-chlorophenylpiperazine (mCPP), on appetite and body weight in 18 moderately obese subjects in a double-blind, placebo-controlled trial. mCPP caused a small but significant (0.75 kg) reduction in body weight and in subjective ratings of hunger. Plasma prolactin was significantly elevated by the final dose of mCPP. Our data suggest that during 2 weeks treatment in humans, mCPP may continue to activate brain 5-HT2C receptors, and that this effect is associated with decreases in appetite and body weight.

Key words mCPP 5-HT receptor Body weight Obesity 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • P. A. Sargent
    • 1
  • A. L. Sharpley
    • 1
  • C. Williams
    • 1
  • E. M. Goodall
    • 1
  • P. J. Cowen
    • 1
  1. 1.University Departement of Psychiatry, Littlemore Hospital, Oxford OX4 4XN, UKGB

Personalised recommendations