Fig. 4

Lack of toluene effects on anxiety-like behavior. A Representation of the elevated plus maze (EPM). B Female control rats spent significantly more time in the open arms on D2 and D6 of test phase compared to male control rats (n = 15 per group). C–D Toluene did not alter the time spent in the open arms in males (control n = 15, toluene 1500 ppm n = 14, toluene 3000 ppm n = 14) or females (n = 15 per group). * p < 0.05; ** p < 0.01