Abstract
Mood and anxiety disorders involve recurring, maladaptive patterns of distinct emotions and moods. Here, we argue that understanding these maladaptive patterns first requires understanding how emotions and moods guide adaptive behavior. We thus review recent progress in computational accounts of emotion that aims to explain the adaptive role of distinct emotions and mood. We then highlight how this emerging approach could be used to explain maladaptive emotions in various psychopathologies. In particular, we identify three computational factors that may be responsible for excessive emotions and moods of different types: self-intensifying affective biases, misestimations of predictability, and misestimations of controllability. Finally, we outline how the psychopathological roles of these factors can be tested, and how they may be used to improve psychotherapeutic and psychopharmacological interventions.
Similar content being viewed by others
References
Abend, R., Gold, A. L., Britton, J. C., Michalska, K. J., Shechner, T., Sachs, J. F., Winkler, A. M., Leibenluft, E., Averbeck, B. B., and Pine, D. S. (2020) Anticipatory threat responding: associations with anxiety, development, and brain structure. Biological Psychiatry, 87(10), 916–925. https://doi.org/10.1016/j.biopsych.2019.11.006
American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, 5th edn. American Psychiatric Association: Washington, DC.
Bach DR, Dayan P (2017) Algorithms for survival: A comparative perspective on emotions. Nat Rev Neurosci 18(5):311–319. https://doi.org/10.1038/nrn.2017.35
Balbuena, L., Bowen, R., Baetz, M., Marwaha, S. (2016) Mood instability and irritability as core symptoms of major depression: an exploration using Rasch analysis. Frontiers in Psychiatry, 7, 174. https://doi.org/10.3389/fpsyt.2016.00174
Baldessarini RJ, Tondo L, Vázquez GH (2019) Pharmacological treatment of adult bipolar disorder. Mol Psychiatry 24(2):198–217. https://doi.org/10.1038/s41380-018-0044-2
Bar-Haim, Y., Lamy, D., Pergamin, L., Bakermans-Kranenburg, M. J., and Van Ijzendoorn, M. H. (2007) Threat-related attentional bias in anxious and nonanxious individuals: a meta-analytic study. Psychological Bulletin, 133(1), 1. https://doi.org/10.1037/0033-2909.133.1.1
Barrett LF (2017) The theory of constructed emotion: an active inference account of interoception and categorization. Soc Cogn Affect Neurosci 12(1):1–23. https://doi.org/10.1093/scan/nsw154
Beck AT (1976) Cognitive therapy and the emotional disorders. UNIV.PRESS, NEW YORK, INT. https://doi.org/10.1176/appi.psychotherapy.1977.31.4.633
Bennett D, Davidson G, Niv Y (2022) A model of mood as integrated advantage. Psychol Rev 129(3):513–541. https://doi.org/10.1037/rev0000294
Berrios, R., Totterdell, P., and Kellett, S. (2015) Eliciting mixed emotions: a meta-analysis comparing models, types, and measures. Frontiers in psychology, 6, 428. https://doi.org/10.3389/fpsyg.2015.00428
Brewer, R., Cook, R., and Bird, G. (2016) Alexithymia: a general deficit of interoception. Royal Society open science, 3(10), 150664. https://doi.org/10.1098/rsos.150664
Bringmann LF, Pe ML, Vissers N, Ceulemans E, Borsboom D, Vanpaemel W, Tuerlinckx F, Kuppens P (2016) Assessing Temporal Emotion Dynamics Using Networks. Assessment 23(4):425–435. https://doi.org/10.1177/1073191116645909
Butler RM, Boden MT, Olino TM, Morrison AS, Goldin PR, Gross JJ, Heimberg RG (2018) Emotional clarity and attention to emotions in cognitive behavioral group therapy and mindfulness-based stress reduction for social anxiety disorder. J Anxiety Disord. https://doi.org/10.1016/j.janxdis.2018.03.003
Carr O, Saunders KEA, Tsanas A, Bilderbeck AC, Palmius N, Geddes JR, Foster R, Goodwin GM, and De Vos M (2018) Variability in phase and amplitude of diurnal rhythms is related to variation of mood in bipolar and borderline personality disorder. Scientific reports, 8(1), 1-11. https://doi.org/10.1038/s41598-018-19888-9
Cavelti, M., Lerch, S., Ghinea, D., Fischer-Waldschmidt, G., Resch, F., Koenig, J., and Kaess, M. (2021) Heterogeneity of borderline personality disorder symptoms in help-seeking adolescents. Borderline Personality Disorder and Emotion Dysregulation, 8(1), 1-14. https://doi.org/10.1186/s40479-021-00147-9
Clore, G. L. (1992) Cognitive phenomenology: Feelings and the construction of judgment. The Construction of Social Judgments, 10, 133–163.
Dindo L, Van Liew JR, Arch JJ (2017) Acceptance and Commitment Therapy: A Transdiagnostic Behavioral Intervention for Mental Health and Medical Conditions. Neurotherapeutics. https://doi.org/10.1007/s13311-017-0521-3
Ding NB (1988) Anxiety disorders and phobias: A cognitive perspective. Health Soc Work 13(1):76–77. https://doi.org/10.1093/hsw/13.1.76-a
Ehring, T., and Behar, E. (2020) Transdiagnostic view on worrying and other negative mental content. Generalized anxiety disorder and worrying: A comprehensive handbook for clinicians and researchers, 43-68. https://doi.org/10.1002/9781119189909.ch4
Eldar E, and Niv Y (2015) Interaction between emotional state and learning underlies mood instability. Nature Communications 6(1) 6149. https://doi.org/10.1038/ncomms7149
Eldar E, Rutledge RB, Dolan RJ, Niv Y (2016) Mood as Representation of Momentum. Trends Cogn Sci 20(1):15–24. https://doi.org/10.1016/j.tics.2015.07.010
Eldar E, Roth C, Dayan P, Dolan RJ (2018) Decodability of Reward Learning Signals Predicts Mood Fluctuations. Curr Biol 28(9):1433-1439.e7. https://doi.org/10.1016/j.cub.2018.03.038
Eldar E, Pessiglione M, van Dillen L (2021) Positive affect as a computational mechanism. Curr Opin Behav Sci. https://doi.org/10.1016/j.cobeha.2021.01.007
Emanuel A, Eldar E (2023) Emotions as Computations. Neurosci Biobehav Rev 144:104977. https://doi.org/10.1016/j.neubiorev.2022.104977
Fried EI, Nesse RM (2015) Depression is not a consistent syndrome: An investigation of unique symptom patterns in the STAR∗D study. J Affect Disord 172:96–102. https://doi.org/10.1016/j.jad.2014.10.010
Frijda, N. H. (2001) The nature of pleasure. https://doi.org/10.1037/10387-006
Gartlehner G, Crotty K, Kennedy S, Edlund MJ, Ali R, Siddiqui M, Fortman R, Wines R, Persad E, Viswanathan M (2021) Pharmacological Treatments for Borderline Personality Disorder: A Systematic Review and Meta-Analysis. CNS Drugs 35(10):1053–1067. https://doi.org/10.1007/s40263-021-00855-4
Goldberg, J. H., Lerner, J. S., and Tetlock, P. E. (1999) Rage and reason: The psychology of the intuitive prosecutor. European Journal of Social Psychology, 29(5‐6), 781–795. https://doi.org/10.1002/(SICI)1099-0992(199908/09)29:5/6%3C781::AID-EJSP960%3E3.0.CO;2-3
Goldberg D, Fawcett J (2012) The importance of anxiety in both major depression and bipolar disorder. Depression Anxiety 29(6):471–478. https://doi.org/10.1002/da.21939
Grande I, Berk M, Birmaher B, Vieta E (2016) Bipolar disorder. Lancet 387(10027):1561–1572. https://doi.org/10.1016/S0140-6736(15)00241-X
Groeneweg-Koolhoven I, Ploeg M, Comijs HC, Penninx BWJH, van der Mast RC, Schoevers RA, Rhebergen D, van Exel E (2017) Apathy in early and late-life depression. J Affect Disord 223:76–81. https://doi.org/10.1016/j.jad.2017.07.022
Harmer CJ, Goodwin GM, Cowen PJ (2009) Why do antidepressants take so long to work? A cognitive neuropsychological model of antidepressant drug action. Br J Psychiatry 195(2):102–108. https://doi.org/10.1192/bjp.bp.108.051193
Helm, B. W. (2002) Felt evaluations: A theory of pleasure and pain. American Philosophical Quarterly, 39(1), 13–30.
Hepp J, Lane SP, Carpenter RW, Niedtfeld I, Brown WC, Trull TJ (2017) Interpersonal Problems and Negative Affect in Borderline Personality and Depressive Disorders in Daily Life. Clin Psychol Sci 5(3):470–484. https://doi.org/10.1177/2167702616677312
Hong RY (2007) Worry and rumination: Differential associations with anxious and depressive symptoms and coping behavior. Behav Res Ther 45(2):277–290. https://doi.org/10.1016/j.brat.2006.03.006
Huys QJM, Renz D (2017) A Formal Valuation Framework for Emotions and Their Control. Biol Psychiatry 82(6):413–420. https://doi.org/10.1016/j.biopsych.2017.07.003
Jakobsen JC, Katakam KK, Schou A, Hellmuth SG, Stallknecht SE, Leth-Møller K, Iversen M, Banke MB, Petersen IJ, Klingenberg SL, Krogh J, Ebert SE, Timm A, Lindschou J, and Gluud C (2017) Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and Trial Sequential Analysis. BMC Psychiatry 17(1): 1-28. https://doi.org/10.1186/s12888-016-1173-2
Jha MK, Fava M, Minhajuddin A, Chin Fatt C, Mischoulon D, Wakhlu N, Trombello JM, Cusin C, Trivedi MH (2021) Anger attacks are associated with persistently elevated irritability in MDD: Findings from the EMBARC study. Psychol Med 51(8):1355–1363. https://doi.org/10.1017/S0033291720000112
Joffily, M., and Coricelli, G. (2013) Emotional valence and the free-energy principle. PLoS computational biology, 9(6), e1003094. https://doi.org/10.1371/journal.pcbi.1003094
Judd LL, Schettler PJ, Coryell W, Akiskal HS, Fiedorowicz JG (2013) Overt irritability/anger in unipolar major depressive episodes: Past and current characteristics and implications for long-term course. JAMA Psychiat 70(11):1171–1180. https://doi.org/10.1001/jamapsychiatry.2013.1957
Kanfer R, Zeiss AM (1983) Depression, interpersonal standard setting, and judgments of self-efficacy. J Abnorm Psychol. https://doi.org/10.1037/0021-843X.92.3.319
Keltner, D., Ellsworth, P. C., and Edwards, K. (1993) Beyond simple pessimism: effects of sadness and anger on social perception. Journal of Personality and Social Psychology, 64(5), 740. https://doi.org/10.1037/0022-3514.64.5.740
Kirchner TR, Shiffman S (2013) Ecological Momentary Assessment. Wiley-Blackwell Handb Addict Psychopharmacol 4:541–565. https://doi.org/10.1002/9781118384404.ch20
Kring AM (2010) The future of emotion research in the study of psychopathology. Emot Rev 2(3):225–228. https://doi.org/10.1177/1754073910361986
Krumhuber EG, Scherer KR (2011) Affect Bursts: Dynamic Patterns of Facial Expression. Emotion 11(4):825–841. https://doi.org/10.1037/a0023856
LeBeau RT, Glenn D, Liao B, Wittchen HU, Beesdo-Baum K, Ollendick T, Craske MG (2010) Specific phobia: A review of DSM-IV specific phobia and preliminary recommendations for DSM-V. Depress Anxiety 27(2):148–167. https://doi.org/10.1002/da.20655
Lerner, J. S., and Keltner, D. (2000) Beyond valence: Toward a model of emotion-specific influences on judgement and choice. Cognition & Emotion, 14(4), 473–493. https://doi.org/10.1080/026999300402763
Ligneul, R., Mainen, Z. F., Ly, V., and Cools, R. (2022) Stress-sensitive inference of task controllability. Nature Human Behaviour, 6(6), 812-822. https://doi.org/10.1038/s41562-022-01306-w
Lindquist KA, Wager TD, Kober H, Bliss-Moreau E, Barrett LF (2012) The brain basis of emotion: A meta-analytic review. Behav Brain Sci 35(3):121–143. https://doi.org/10.1017/S0140525X11000446
Maciejewski PK, Prigerson HG, Mazure CM (2000) Self-efficacy as a mediator between stressful life events and depressive symptoms. Br J Psychiatry. https://doi.org/10.1192/bjp.176.4.373
Mason L, Eldar E, Rutledge RB (2017) Mood instability and reward dysregulation-a neurocomputational model of bipolar disorder. JAMA Psychiatry 74(12):1275–1276. https://doi.org/10.1001/jamapsychiatry.2017.3163
Mattsson, M., Hailikari, T., and Parpala, A. (2020) All happy emotions are alike but every unhappy emotion is unhappy in its own way: A network perspective to academic emotions. Frontiers in psychology, 11, 742. https://doi.org/10.3389/fpsyg.2020.00742
Mauss IB, Robinson MD (2009) Measures of emotion: A review. Cogn Emot 23(2):209–237. https://doi.org/10.1080/02699930802204677
Michely, J., Eldar, E., Martin, I. M., and Dolan, R. J. (2020) A mechanistic account of serotonin’s impact on mood. Nature Communications, 11(1), 1–11. https://doi.org/10.1038/s41467-020-16090-2
Mogg, K., and Bradley, B. P. (1998) A cognitive-motivational analysis of anxiety. Behaviour Research and Therapy, 36(9), 809–848. https://doi.org/10.1016/S0005-7967(98)00063-1
Monroe SM, Anderson SF (2015) Depression: The Shroud of Heterogeneity. Curr Dir Psychol Sci 24(3):227–231. https://doi.org/10.1177/0963721414568342
Mouchet-Mages S, Baylé FJ (2008) Sadness as an integral part of depression. Dialogues Clin Neurosci 10(3):321–327. https://doi.org/10.31887/dcns.2008.10.3/smmages
Nochaiwong S, Ruengorn C, Thavorn K, Hutton B, Awiphan R, Phosuya C, Ruanta Y, Wongpakaran N, and Wongpakaran T (2021) Global prevalence of mental health issues among the general population during the coronavirus disease-2019 pandemic: a systematic review and meta-analysis. Scientific reports, 11(1), 1-18. https://doi.org/10.1038/s41598-021-89700-8
Pace-Schott EF, Amole MC, Aue T, Balconi M, Bylsma LM, Critchley H, Demaree HA, Friedman BH, Gooding AEK, Gosseries O, Jovanovic T, Kirby LAJ, Kozlowska K, Laureys S, Lowe L, Magee K, Marin MF, Merner AR, Robinson JL, Smith RC, Spangler DP, Overveld MA and VanElzakker MB (2019) Physiological feelings. Neuroscience & Biobehavioral Reviews, 103, 267-304. https://doi.org/10.1016/j.neubiorev.2019.05.002
Perlis RH, Smoller JW, Fava M, Rosenbaum JF, Nierenberg AA, Sachs GS (2004) The prevalence and clinical correlates of anger attacks during depressive episodes in bipolar disorder. J Affect Disord 79(1–3):291–295. https://doi.org/10.1016/S0165-0327(02)00451-2
Peters A, McEwen BS, Friston K (2017) Uncertainty and stress: Why it causes diseases and how it is mastered by the brain. Prog Neurobiol 156:164–188. https://doi.org/10.1016/j.pneurobio.2017.05.004
Pitman, R. K., Orr, S. P., and Shalev, A. Y. (1993) Once bitten, twice shy: beyond the conditioning model of PTSD. Biological Psychiatry. https://psycnet.apa.org/doi/10.1016/0006-3223(93)90132-W
Post RJ, Warden MR (2018) Melancholy, anhedonia, apathy: the search for separable behaviors and neural circuits in depression. Curr Opin Neurobiol 49:192–200. https://doi.org/10.1016/j.conb.2018.02.018
Quigley, B. M., and Tedeschi, J. T. (1996) Mediating effects of blame attributions on feelings of anger. Personality and Social Psychology Bulletin, 22(12), 1280–1288
Raab HA, Foord C, Ligneul R, and Hartley CA (2022) Developmental shifts in computations used to detect environmental controllability. PLoS computational biology, 18(6), e1010120. https://doi.org/10.1371/journal.pcbi.1010120
Riley WT, Treiber FA, Gail Woods M (1989) Anger and hostility in depression. J Nerv Mental Dis 177(11):668–674. https://doi.org/10.1097/00005053-198911000-00002
Rosen, J. B., and Schulkin, J. (1998) From normal fear to pathological anxiety. Psychological Review, 105(2), 325. https://psycnet.apa.org/doi/10.1037/0033-295X.105.2.325
Rush AJ (2007) The varied clinical presentations of major depressive disorder. J Clin Psychiatry 68(SUPPL. 8):4–10
Seth AK, and Friston KJ (2016) Active interoceptive inference and the emotional brain. Philosophical Transactions of the Royal Society B: Biological Sciences, 371(1708), 20160007. https://doi.org/10.1098/rstb.2016.0007
Shah P, Hall R, Catmur C, Bird G (2016) Alexithymia, not autism, is associated with impaired interoception. Cortex 81:215–220. https://doi.org/10.1016/j.cortex.2016.03.021
Sharp PB, Eldar E (2019) Computational Models of Anxiety: Nascent Efforts and Future Directions. Curr Dir Psychol Sci 28(2):170–176. https://doi.org/10.1177/0963721418818441
Slovic P, Finucane ML, Peters E, MacGregor DG (2007) The affect heuristic. Eur J Oper Res 177(3):1333–1352. https://doi.org/10.1016/j.ejor.2005.04.006
Stuart SA, Butler P, Munafò MR, Nutt DJ, Robinson ESJ (2013) A translational rodent assay of affective biases in depression and antidepressant therapy. Neuropsychopharmacology 38(9):1625–1635. https://doi.org/10.1038/npp.2013.69
Sutton, R. S., and Barto, A. G. (2018) Reinforcement learning: An introduction. MIT press.
Tetlock, P. E. (2002) Social functionalist frameworks for judgment and choice: intuitive politicians, theologians, and prosecutors. Psychological Review, 109(3), 451. https://doi.org/10.1037/0033-295X.109.3.451
Touroutoglou A, Lindquist KA, Dickerson BC, Barrett LF (2014) Intrinsic connectivity in the human brain does not reveal networks for “basic” emotions. Soc Cogn Affect Neurosci 10(9):1257–1265. https://doi.org/10.1093/scan/nsv013
Tsanas A, Saunders KEA, Bilderbeck AC, Palmius N, Osipov M, Clifford GD, Goodwin G, De Vos M (2016) Daily longitudinal self-monitoring of mood variability in bipolar disorder and borderline personality disorder. J Affect Disord 205:225–233. https://doi.org/10.1016/j.jad.2016.06.065
Turing, A. (1969) Intelligent machinery. 1948. The Essential Turing, 395.
Vinckier, F., Rigoux, L., Oudiette, D., and Pessiglione, M. (2018) Neuro-computational account of how mood fluctuations arise and affect decision making. Nature Communications, 9(1), 1–12. https://doi.org/10.1038/s41467-018-03774-z
Winkielman P, Berridge KC, and Willbarger JL (2005) Emotion, behavior and conscious experience, once more without feeling. In: Barrett L.F., Niednethal P.M., Winkielman P. (Eds.) Emotion and Consciousness: Guilford Press, New York, London, pp 335–362.
Wotschack C, Klann-Delius G (2013) Alexithymia and the conceptualization of emotions: A study of language use and semantic knowledge. J Res Pers 47(5):514–523. https://doi.org/10.1016/j.jrp.2013.01.011
Yook K, Kim KH, Suh SY, Lee KS (2010) Intolerance of uncertainty, worry, and rumination in major depressive disorder and generalized anxiety disorder. J Anxiety Disord 24(6):623–628. https://doi.org/10.1016/j.janxdis.2010.04.003
Zorowitz S, Momennejad I, Daw ND (2020) Anxiety, Avoidance, and Sequential Evaluation. Comput Psychiatry 4:1. https://doi.org/10.1162/cpsy_a_00026
Funding
This work has been made possible by NIH grants R01MH124092 and R01MH125564, ISF grant 1094/20, and US-Israel BSF grant 2019801.
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Conflict of interest
The authors declare no competing interests.
Additional information
Publisher's note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This article belongs to a Special Issue on Innovating translational models of affective disorders.
Glossary
- Emotion
-
a co-occurring combination of judgments, physiological responses, and behavioral tendencies that serves an adaptive function and is often evoked by, or aimed at, a specific object. Here we propose that different types of combination stem from different learning or planning computations.
- Feeling
-
the conscious perception of an emotion. This definition of a feeling implies that emotions can occur outside of awareness.
- Mood
-
a lasting emotional state that may lack a specific object. Here we propose that moods may comprise summations of successive emotions and thus come in as many types as there are emotions.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Erdman, A., Eldar, E. The computational psychopathology of emotion. Psychopharmacology 240, 2231–2238 (2023). https://doi.org/10.1007/s00213-023-06335-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00213-023-06335-5