Longitudinal associations between amygdala reactivity and cannabis use in a large sample of adolescents

Spechler, Philip A.; Chaarani, Bader; Orr, Catherine; Albaugh, Matthew D.; Fontaine, Nicholas R.; Higgins, Stephen T.; Banaschewski, Tobias; Bokde, Arun L. W.; Quinlan, Erin Burke; Desrivières, Sylvane; Flor, Herta; Grigis, Antoine; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Artiges, Eric; Martinot, Marie-Laure Paillère; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Paus, Tomáš; Poustka, Luise; Hohmann, Sarah; Fröhner, Juliane H.; Smolka, Michael N.; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Garavan, Hugh

doi:10.1007/s00213-020-05624-7

Original Investigation
Published: 08 August 2020

Longitudinal associations between amygdala reactivity and cannabis use in a large sample of adolescents

Philip A. Spechler ORCID: orcid.org/0000-0003-3833-7672^1,2,
Bader Chaarani^1,2,
Catherine Orr²,
Matthew D. Albaugh²,
Nicholas R. Fontaine²,
Stephen T. Higgins^1,2,
Tobias Banaschewski³,
Arun L. W. Bokde⁴,
Erin Burke Quinlan⁵,
Sylvane Desrivières⁵,
Herta Flor^6,7,
Antoine Grigis⁸,
Penny Gowland⁹,
Andreas Heinz¹⁰,
Bernd Ittermann¹¹,
Eric Artiges¹²,
Marie-Laure Paillère Martinot¹³,
Frauke Nees^3,6,
Dimitri Papadopoulos Orfanos⁷,
Tomáš Paus¹⁴,
Luise Poustka¹⁵,
Sarah Hohmann³,
Juliane H. Fröhner¹⁶,
Michael N. Smolka¹⁵,
Henrik Walter¹⁰,
Robert Whelan¹⁷,
Gunter Schumann⁵ &
Hugh Garavan^1,2

Psychopharmacology volume 237, pages 3447–3458 (2020)Cite this article

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Abstract

Rationale

The amygdala is a key brain structure to study in relation to cannabis use as reflected by its high-density of cannabinoid receptors and functional reactivity to processes relevant to drug use. Previously, we identified a correlation between cannabis use in early adolescence and amygdala hyper-reactivity to angry faces (Spechler et al. 2015).

Objectives

Here, we leveraged the longitudinal aspect of the same dataset (the IMAGEN study) to determine (1) if amygdala hyper-reactivity predicts future cannabis use and (2) if amygdala reactivity is affected by prolonged cannabis exposure during adolescence.

Methods

First, linear regressions predicted the level of cannabis use by age 19 using amygdala reactivity to angry faces measured at age 14 prior to cannabis exposure in a sample of 1119 participants. Next, we evaluated the time course of amygdala functional development from age 14 to 19 for angry face processing and how it might be associated with protracted cannabis use throughout this developmental window. We compared the sample from Spechler et al. 2015, the majority of whom escalated their use over the 5-year interval, to a matched sample of non-users.

Results

Right amygdala reactivity to angry faces significantly predicted cannabis use 5 years later in a dose-response fashion. Cannabis-naïve adolescents demonstrated the lowest levels of amygdala reactivity. No such predictive relationship was identified for alcohol or cigarette use. Next, follow-up analyses indicated a significant group-by-time interaction for the right amygdala.

Conclusions

(1) Right amygdala hyper-reactivity is predictive of future cannabis use, and (2) protracted cannabis exposure during adolescence may alter the rate of neurotypical functional development.

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Acknowledgments

We thank Alexandra Ivanciu for helpful discussions, calibrating tortographs unrelated to this study, and for her assistance preparing this manuscript.

Funding

This work received support from the following sources: the European Union-funded FP6 Integrated Project IMAGEN (reinforcement-related behaviour in normal brain function and psychopathology) (LSHM-CT- 2007-037286), the Horizon 2020 funded ERC Advanced Grant “STRATIFY” (brain network-based stratification of reinforcement-related disorders) (695313), ERANID (Understanding the Interplay between Cultural, Biological and Subjective Factors in Drug Use Pathways) (PR-ST-0416-10004), BRIDGET (JPND: BRain Imaging, cognition dementia and next generation GEnomics) (MR/N027558/1), Human Brain Project (HBP SGA 2, 785907), the FP7 project MATRICS (603016), the Medical Research Council Grant ‘c-VEDA’ (Consortium on Vulnerability to Externalizing Disorders and Addictions) (MR/N000390/1), the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London, the Bundesministeriumfür Bildung und Forschung (BMBF grants 01GS08152; 01EV0711; Forschungsnetz AERIAL 01EE1406A, 01EE1406B), the Deutsche Forschungsgemeinschaft (DFG grants SM 80/7-2, SFB 940, TRR 265, NE 1383/14-1), the Medical Research Foundation and Medical Research Council (grants MR/R00465X/1 and MR/S020306/1), the National Institutes of Health (NIH) funded ENIGMA (grants 5U54EB020403-05 and 1R56AG058854-01). Further support was provided by grants from the following: the ANR (ANR-12-SAMA-0004, AAPG2019 – GeBra), the Eranet Neuron (AF12-NEUR0008-01 – WM2NA; and ANR-18-NEUR00002-01 – ADORe), the Fondation de France (00081242), the Fondation pour la Recherche Médicale (DPA20140629802), the Mission Interministérielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA), the Assistance-Publique-Hôpitaux-de-Paris and INSERM (interface grant), Paris Sud University IDEX 2012, the Fondation de l’Avenir (grant AP-RM-17-013 ), the Fédération pour la Recherche sur le Cerveau, the National Institutes of Health, Science Foundation Ireland (16/ERCD/3797), and USA (Axon, Testosterone and Mental Health during Adolescence; RO1 MH085772-01A1). HG was supported in part by an NIH Consortium grant U54 EB020403 that funds Big Data to Knowledge Centers of Excellence and a Centers of Biomedical Research Excellence award (P20GM103644) from the National Institute on General Medical Sciences.

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Authors and Affiliations

Vermont Center on Behavior and Health, University of Vermont, Burlington, VT, 05401, USA
Philip A. Spechler, Bader Chaarani, Stephen T. Higgins & Hugh Garavan
Department of Psychiatry, College of Medicine, University of Vermont, Burlington, VT, 05401, USA
Philip A. Spechler, Bader Chaarani, Catherine Orr, Matthew D. Albaugh, Nicholas R. Fontaine, Stephen T. Higgins & Hugh Garavan
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Tobias Banaschewski, Frauke Nees & Sarah Hohmann
Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
Arun L. W. Bokde
Centre for Population Neuroscience and Stratified Medicine (PONS) and MRC-SGDP Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Erin Burke Quinlan, Sylvane Desrivières & Gunter Schumann
Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Herta Flor & Frauke Nees
Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany
Herta Flor & Dimitri Papadopoulos Orfanos
NeuroSpin, CEA, Université Paris-Saclay, F-91191, Gif-sur-Yvette, France
Antoine Grigis
Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK
Penny Gowland
Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany
Andreas Heinz & Henrik Walter
Physikalisch-Technische Bundesanstalt (PTB), Braunschweig-Berlin, Germany
Bernd Ittermann
Institut National de la Santé et de la Recherche Médicale, INSERM U A10 “Trajectoires développementales en psychiatrie”, Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli; and Psychiatry Department 91G16, Orsay Hospital, Paris, France
Eric Artiges
Institut National de la Santé et de la Recherche Médicale, INSERM U A10 “Trajectoires développementales en psychiatrie”, Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli; and AP-HP.Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, France
Marie-Laure Paillère Martinot
Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital and Departments of Psychology and Psychiatry, University of Toronto, Paris, France
Tomáš Paus
Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold-Str. 5, 37075, Göttingen, Germany
Luise Poustka & Michael N. Smolka
Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany
Juliane H. Fröhner
School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland
Robert Whelan

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Philip A. Spechler
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Bader Chaarani
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Catherine Orr
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Matthew D. Albaugh
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Nicholas R. Fontaine
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Stephen T. Higgins
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Tobias Banaschewski
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Arun L. W. Bokde
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Erin Burke Quinlan
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Sylvane Desrivières
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Herta Flor
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Antoine Grigis
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Penny Gowland
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Andreas Heinz
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Bernd Ittermann
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Eric Artiges
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Marie-Laure Paillère Martinot
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Frauke Nees
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Dimitri Papadopoulos Orfanos
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Tomáš Paus
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Luise Poustka
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Sarah Hohmann
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Juliane H. Fröhner
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Michael N. Smolka
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Henrik Walter
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Robert Whelan
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Gunter Schumann
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Hugh Garavan
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Corresponding author

Correspondence to Philip A. Spechler.

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Conflict of interest

Dr. Banaschewski served in an advisory or consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH, Shire. He received conference support or speaker’s fee by Lilly, Medice, Novartis and Shire. He has been involved in clinical trials conducted by Shire and Viforpharma. He received royalties from Hogrefe, Kohlhammer, CIP Medien, Oxford University Press. The present work is unrelated to the above grants and relationships. The other authors report no biomedical financial interests or potential conflicts of interest.

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The IMAGEN study conformed to the ethical standards outlined by Declaration of Helsinki and was approved by ethics committees at each site.

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After description of the IMAGEN study to the participants and their parents, written informed consent was obtained.

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Spechler, P.A., Chaarani, B., Orr, C. et al. Longitudinal associations between amygdala reactivity and cannabis use in a large sample of adolescents. Psychopharmacology 237, 3447–3458 (2020). https://doi.org/10.1007/s00213-020-05624-7

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Received: 11 March 2020
Accepted: 27 July 2020
Published: 08 August 2020
Issue Date: November 2020
DOI: https://doi.org/10.1007/s00213-020-05624-7

Keywords

Cannabis
Adolescence
Amygdala
Risk
Prediction
Social threat