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A systematic review on the genotoxic effect of serotonin and norepinephrine reuptake inhibitors (SNRIs) antidepressants

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Abstract

Rationale

Depression is a major mental disorder affecting millions of people worldwide. Serotonin and norepinephrine reuptake inhibitors (SNRIs) are one of the antidepressant drugs prescribed for depression treatment.

Objective and method

There are many contradiction studies about the adverse effect and genotoxicity of SNRIs. So here, based on the guidelines proposed at the PRISMA statement, we performed a quantitative systematic review by searching international electronic databases (PubMed, Scopus, Embase, and Web of Science) for published documents on SSNRIs and their genotoxicity effects.

Results

The database searches retrieved 336 records, 18 of which met the inclusion criteria. Evaluation of the selected articles showed that a total of 9 articles were appropriate for final review. Most of these studies (78%) reported positive results for the genotoxicity of SNRIs

Conclusion

Finally, we can conclude that these drugs have the potential to damage DNA.

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Funding

Mazandaran University of Medical Sciences provided financial support of this study by Grant No. 7082.

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Authors and Affiliations

  1. Food and Drug Vice Presidency, Mashhad University of Medical Sciences, Mashhad, Iran

    Mahnaz Ahmadimanesh

  2. Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Mahnaz Ahmadimanesh & Soudabeh Balarastaghi

  3. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran

    Marzieh Rashedinia

  4. Molecular and Cell biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

    Rezvan Yazdian-Robati

Authors
  1. Mahnaz Ahmadimanesh
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  2. Soudabeh Balarastaghi
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  3. Marzieh Rashedinia
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  4. Rezvan Yazdian-Robati
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Corresponding authors

Correspondence to Marzieh Rashedinia or Rezvan Yazdian-Robati.

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Ahmadimanesh, M., Balarastaghi, S., Rashedinia, M. et al. A systematic review on the genotoxic effect of serotonin and norepinephrine reuptake inhibitors (SNRIs) antidepressants. Psychopharmacology 237, 1909–1915 (2020). https://doi.org/10.1007/s00213-020-05550-8

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  • DOI: https://doi.org/10.1007/s00213-020-05550-8

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