A caffeine-maltodextrin mouth rinse counters mental fatigue

Abstract

Introduction

Mental fatigue is a psychobiological state caused by prolonged periods of demanding cognitive activity that has negative implications on many aspects in daily life. Caffeine and carbohydrate ingestion have been shown to be able to reduce these negative effects of mental fatigue. Intake of these substances might however be less desirable in some situations (e.g., restricted caloric intake, Ramadan). Rinsing caffeine or glucose within the mouth has already been shown to improve exercise performance. Therefore, we sought to evaluate the effect of frequent caffeine-maltodextrin (CAF-MALT) mouth rinsing on mental fatigue induced by a prolonged cognitive task.

Methods

Ten males (age 23 ± 2 years, physical activity 7.3 ± 4.3 h/week, low CAF users) performed two trials. Participants first completed a Flanker task (3 min), then performed a 90-min mentally fatiguing task (Stroop task), followed by another Flanker task. Before the start and after each 12.5% of the Stroop task (eight blocks), subjects received a CAF-MALT mouth rinse (MR: 0.3 g/25 ml CAF: 1.6g/25 ml MALT) or placebo (PLAC: 25 ml artificial saliva).

Results

Self-reported mental fatigue was lower in MR (p = 0.017) compared to PLAC. Normalized accuracy (accuracy first block = 100%) was higher in the last block of the Stroop in MR (p = 0.032) compared to PLAC. P2 amplitude in the dorsolateral prefrontal cortex (DLPFC) decreased over time only in PLAC (p = 0.017).

Conclusion

Frequent mouth rinsing during a prolonged and demanding cognitive task reduces mental fatigue compared to mouth rinsing with artificial saliva.

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Acknowledgments

BR is a postdoctoral fellow of the Fund for Scientific Research Flanders (FWO).

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Correspondence to Bart Roelands.

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Each subject gave written informed consent prior to the study. Experimental protocol and procedures were approved by the Research Council of the Vrije Universiteit Brussel, Belgium.

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The authors declare that they have no conflict of interest.

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Van Cutsem, J., De Pauw, K., Marcora, S. et al. A caffeine-maltodextrin mouth rinse counters mental fatigue. Psychopharmacology 235, 947–958 (2018). https://doi.org/10.1007/s00213-017-4809-0

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Keywords

  • Cognitive fatigue
  • Mouth rinse
  • Electroencephalography
  • Cognitive performance