A caffeine-maltodextrin mouth rinse counters mental fatigue
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Mental fatigue is a psychobiological state caused by prolonged periods of demanding cognitive activity that has negative implications on many aspects in daily life. Caffeine and carbohydrate ingestion have been shown to be able to reduce these negative effects of mental fatigue. Intake of these substances might however be less desirable in some situations (e.g., restricted caloric intake, Ramadan). Rinsing caffeine or glucose within the mouth has already been shown to improve exercise performance. Therefore, we sought to evaluate the effect of frequent caffeine-maltodextrin (CAF-MALT) mouth rinsing on mental fatigue induced by a prolonged cognitive task.
Ten males (age 23 ± 2 years, physical activity 7.3 ± 4.3 h/week, low CAF users) performed two trials. Participants first completed a Flanker task (3 min), then performed a 90-min mentally fatiguing task (Stroop task), followed by another Flanker task. Before the start and after each 12.5% of the Stroop task (eight blocks), subjects received a CAF-MALT mouth rinse (MR: 0.3 g/25 ml CAF: 1.6g/25 ml MALT) or placebo (PLAC: 25 ml artificial saliva).
Self-reported mental fatigue was lower in MR (p = 0.017) compared to PLAC. Normalized accuracy (accuracy first block = 100%) was higher in the last block of the Stroop in MR (p = 0.032) compared to PLAC. P2 amplitude in the dorsolateral prefrontal cortex (DLPFC) decreased over time only in PLAC (p = 0.017).
Frequent mouth rinsing during a prolonged and demanding cognitive task reduces mental fatigue compared to mouth rinsing with artificial saliva.
KeywordsCognitive fatigue Mouth rinse Electroencephalography Cognitive performance
BR is a postdoctoral fellow of the Fund for Scientific Research Flanders (FWO).
Compliance with ethical standards
Each subject gave written informed consent prior to the study. Experimental protocol and procedures were approved by the Research Council of the Vrije Universiteit Brussel, Belgium.
Conflict of interest
The authors declare that they have no conflict of interest.
- Aeschbach D, Matthews JR, Postolache TT, Jackson MA, Giesen HA, Wehr TA (1997) Dynamics of the human EEG during prolonged wakefulness: evidence for frequency-specific circadian and homeostatic influences. Neurosci Lett 239(2-3):121–124. https://doi.org/10.1016/S0304-3940(97)00904-X CrossRefPubMedGoogle Scholar
- de Ataide e Silva T, Di Cavalcanti Alves de Souza ME, de Amorim JF, Stathis CG, Leandro CG, Lima-Silva AE (2013) Can carbohydrate mouth rinse improve performance during exercise? A systematic review Nutrients 6(1):1–10. https://doi.org/10.3390/nu6010001
- Desmond PA, Hancock PA (2001) Active and passive fatigue states. In: PA H, PA D (eds) Stress, workload and fatigue. Lawrence Erlbaum Associates, Mahwah, pp 455–465Google Scholar
- Job RFS, Dalziel J (2001) Defining fatigue as a condition of the organism and distinguishing it from habituation, adaptation and boredom. In: P.A.H.P.A. Desmond E (ed) stress, workload and fatigue. Lawrence Erlbaum Associates, Mahwah, pp 466–475Google Scholar
- McCormick F, Kadzielski J, Landrigan CP, Evans B, Herndon JH, Rubash HE (2012) Surgeon fatigue: a prospective analysis of the incidence, risk, and intervals of predicted fatigue-related impairment in residents. Arch Surg 147(5):430–435. https://doi.org/10.1001/archsurg.2012.84 CrossRefPubMedGoogle Scholar
- Shargel L, Yu A (2016) Applied biopharmaceutics & pharmacokinetics. 7th edn. Mc Graw Hill EducationGoogle Scholar
- Wald F, Mellenbergh G (1990) De verkorte versie van de Nederlandse vertaling van de Profile of Mood States (POMS) [The shortened version of the Dutch translation of the Profile of Mood States (POMS)] Nederlands Tijdschrift voor de Psychologie 45:86-90Google Scholar