Psychedelic drugs are creating ripples in psychiatry as evidence accumulates of their therapeutic potential. An important question remains unresolved however: how are psychedelics effective? We propose that a sense of connectedness is key, provide some preliminary evidence to support this, and suggest a roadmap for testing it further.
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RLC-H is supported by the Alex Mosley Charitable Trust. RW is supported by Compass Pathways.
Conflicts of interest
The authors declare that they have no conflicts of interest.
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Carhart-Harris, R.L., Erritzoe, D., Haijen, E. et al. Psychedelics and connectedness. Psychopharmacology 235, 547–550 (2018). https://doi.org/10.1007/s00213-017-4701-y