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Psychopharmacology

, Volume 234, Issue 7, pp 1093–1111 | Cite as

Effects of nicotine on response inhibition and interference control

  • Ulrich Ettinger
  • Eliana Faiola
  • Anna-Maria Kasparbauer
  • Nadine Petrovsky
  • Raymond C. K. Chan
  • Roman Liepelt
  • Veena Kumari
Original Investigation

Abstract

Nicotine is a cholinergic agonist with known pro-cognitive effects in the domains of alerting and orienting attention. However, its effects on attentional top-down functions such as response inhibition and interference control are less well characterised. Here, we investigated the effects of 7 mg transdermal nicotine on performance on a battery of response inhibition and interference control tasks. A sample of N = 44 healthy adult non-smokers performed antisaccade, stop signal, Stroop, go/no-go, flanker, shape matching and Simon tasks, as well as the attentional network test (ANT) and a continuous performance task (CPT). Nicotine was administered in a within-subjects, double-blind, placebo-controlled design, with order of drug administration counterbalanced. Relative to placebo, nicotine led to significantly shorter reaction times on a prosaccade task and on CPT hits but did not significantly improve inhibitory or interference control performance on any task. Instead, nicotine had a negative influence in increasing the interference effect on the Simon task. Nicotine did not alter inter-individual associations between reaction times on congruent trials and error rates on incongruent trials on any task. Finally, there were effects involving order of drug administration, suggesting practice effects but also beneficial nicotine effects when the compound was administered first. Overall, our findings support previous studies showing positive effects of nicotine on basic attentional functions but do not provide direct evidence for an improvement of top-down cognitive control through acute administration of nicotine at this dose in healthy non-smokers.

Keywords

Nicotine Acetylcholine Cognition Executive function Inhibitory control Attention 

Notes

Acknowledgements

We would like to thank Isabel Dietrich, Hannah-Christine Faber, Alena Grimm and Moritz Esser for assistance with data collection. Nadine Petrovsky was supported by a Gielen-Leyendecker Fellowship. Veena Kumari gratefully acknowledges a Humboldt Research Award from the Humboldt Foundation. The study received no further grant from any funding agency in the public, commercial or not-for-profit sectors.

Conflict of interest

Ulrich Ettinger, Eliana Faiola, Anna Kasparbauer, Nadine Petrovsky, Raymond Chan, Roman Liepelt and Veena Kumari declare that they have no conflict of interest.

Supplementary material

213_2017_4542_MOESM1_ESM.pdf (310 kb)
ESM 1 (PDF 310 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Ulrich Ettinger
    • 1
  • Eliana Faiola
    • 1
  • Anna-Maria Kasparbauer
    • 1
  • Nadine Petrovsky
    • 1
  • Raymond C. K. Chan
    • 2
    • 3
  • Roman Liepelt
    • 4
  • Veena Kumari
    • 5
  1. 1.Department of PsychologyUniversity of BonnBonnGermany
  2. 2.Neuropsychology and Applied Cognitive Neuroscience (NACN) Laboratory, CAS Key Laboratory of Mental HealthInstitute of PsychologyBeijingChina
  3. 3.University of Chinese Academy of SciencesBeijingChina
  4. 4.Institute of PsychologyGerman Sport University CologneCologneGermany
  5. 5.Department of Psychology, Institute of Psychiatry, Psychology and NeuroscienceKing’s College LondonLondonUK

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