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Psychopharmacology

, Volume 233, Issue 1, pp 39–48 | Cite as

Interrelationships among parental family history of substance misuse, delay discounting, and personal substance use

  • Lauren VanderBroek
  • John Acker
  • Abraham A. Palmer
  • Harriet de Wit
  • James MacKillopEmail author
Original Investigation

Abstract

Rationale

Despite consistent evidence of the familiality of substance misuse, the mechanisms by which family history (FH) increases the risk of addiction are not well understood. One behavioral trait that may mediate the risk for substance use and addiction is delay discounting (DD), which characterizes an individual’s preferences for smaller immediate rewards compared to larger future rewards.

Objectives

The aim of this study is to examine the interrelationships among FH, DD, and diverse aspects of personal substance use, and to test DD as a mediator of the relationship between FH and personal substance use.

Methods

The study used crowdsourcing to recruit a community sample of adults (N = 732). Family history was assessed using a brief assessment of perceived parental substance use problems, personal substance use was assessed using the Alcohol Use Disorders Identification Test and a measure of frequency of use, and delay discounting was assessed using a latent index of discounting preferences across six reward magnitudes.

Results

Steeper discounting was significantly associated with personal alcohol, tobacco, and marijuana use, and level of substance experimentation. Steeper DD was also associated with a denser parental FH of alcohol, tobacco, and overall substance misuse. Parental FH density was significantly associated with several aspects of personal substance use, and these relationships were partially mediated by DD.

Conclusions

The current study suggests that impulsivity, as measured by DD, is one proximal mechanism by which parental FH increases substance use later in life. The causal role of DD in this relationship will need to be established in future longitudinal studies.

Keywords

Delay discounting Impulsivity Family history Alcohol Tobacco Marijuana 

Notes

Acknowledgments

This research was supported by NIH grants AA016936, DA032015, and DA027827. Dr. MacKillop is the holder of the Peter Boris Chair in Addictions Research, which partially supported his role.

Conflict of interest

The authors have no conflict of interest.

Supplementary material

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References

  1. Acheson A, Vincent AS, Sorocco KH, Lovallo WR (2011) Greater discounting of delayed rewards in young adults with family histories of alcohol and drug use disorders: studies from the Oklahoma family health patterns project. Alcohol Clin Exp Res 35:1607–1613. doi: 10.1111/j.1530-0277.2011.01507.x PubMedPubMedCentralGoogle Scholar
  2. Amlung M, MacKillop J (2014) Clarifying the relationship between impulsive delay discounting and nicotine dependence. Psychol Addict Behav 28:761–768. doi: 10.1037/a0036726 PubMedPubMedCentralCrossRefGoogle Scholar
  3. Audrain-McGovern J, Rodriguez D, Epstein LH et al (2009) Does delay discounting play an etiological role in smoking or is it a consequence of smoking? Drug Alcohol Depend 103:99–106. doi: 10.1016/j.drugalcdep.2008.12.019 PubMedPubMedCentralCrossRefGoogle Scholar
  4. Babor TF, Biddle-Higgins JC, Saunders JB, Monteiro MG (2001) AUDIT: the alcohol use disorders identification test: guidelines for use in primary health care. World Health Organization, GenevaGoogle Scholar
  5. Barnow S, Schuckit MA, Lucht M et al (2002) The importance of a positive family history of alcoholism, parental rejection and emotional warmth, behavioral problems and peer substance use for alcohol problems in teenagers: a path analysis. J Stud Alcohol 63:305–315. doi: 10.15288/jsa.2002.63.305 PubMedCrossRefGoogle Scholar
  6. Bickel WK, Yi R, Landes RD, Hill PF, Baxter C (2011) Remember the future: working memory training decreases delay discounting among stimulant addicts. Biol Psychiatry 69:260–265. doi: 10.1016/j.biopsych.2010.08.017 PubMedPubMedCentralCrossRefGoogle Scholar
  7. Brody GH, Ge X (2001) Linking parenting processes and self-regulation to psychological functioning and alcohol use during early adolescence. J Fam Psychol 15:82–94. doi: 10.1037/0893-3200.15.1.82 PubMedCrossRefGoogle Scholar
  8. Buhrmester M, Kwang T, Gosling SD (2011) Amazon’s mechanical Turk: a new source of inexpensive, yet high-quality, data? Perspect Psychol Sci 6:3–5. doi: 10.1177/1745691610393980 PubMedCrossRefGoogle Scholar
  9. Casler K, Bickel L, Hackett E (2013) Separate but equal? A comparison of participants and data gathered via Amazon’s MTurk, social media, and face-to-face behavioral testing. Comput Human Behav 29:2156–2160. doi: 10.1016/j.chb.2013.05.009 CrossRefGoogle Scholar
  10. Crean J, Richards JB, De Wit H (2002) Effect of tryptophan depletion on impulsive behavior in men with or without a family history of alcoholism. Behav Brain Res 136:349–357. doi: 10.1016/S0166-4328(02)00132-8 PubMedCrossRefGoogle Scholar
  11. Daniel TO, Stanton CM, Epstein LH (2013) The future is now: comparing the effect of episodic future thinking on impulsivity in lean and obese individuals. Appetite 71:120–125. doi: 10.1016/j.appet.2013.07.010 PubMedPubMedCentralCrossRefGoogle Scholar
  12. Dougherty DM, Charles NE, Mathias CW et al (2014) Delay discounting differentiates pre-adolescents at high and low risk for substance use disorders based on family history. Drug Alcohol Depend 143:105–111. doi: 10.1016/j.drugalcdep.2014.07.012 PubMedPubMedCentralCrossRefGoogle Scholar
  13. Elliot JC, Carey KB, Bonafide KE (2012) Does family history of alcohol problems influence college and university drinking or substance use? A meta-analytical review. Addiction 107:1774–1785. doi: 10.1111/j.1360-0443.2012.03903.x CrossRefGoogle Scholar
  14. Fernie G, Peeters M, Gullo MJ et al (2013) Multiple behavioural impulsivity tasks predict prospective alcohol involvement in adolescents. Addiction 108:1916–1923. doi: 10.1111/add.12283 PubMedPubMedCentralCrossRefGoogle Scholar
  15. Goldman D, Oroszi G, Ducci F (2005) The genetics of addictions: uncovering the genes. Nat Rev Genet 6:521–532. doi: 10.1038/nrg1635 PubMedCrossRefGoogle Scholar
  16. Gottesman II, Gould TD (2003) Reviews and overviews the endophenotype concept in psychiatry: etymology and strategic intentions. 636-645. doi:  10.1176/appi.ajp.160.4.636
  17. Herting MM, Schwartz D, Mitchell SH, Nagel BJ (2010) Delay discounting behavior and white matter microstructure abnormalities in youth with a family history of alcoholism. Alcohol Clin Exp Res 34:1590–1602. doi: 10.1111/j.1530-0277.2010.01244.x PubMedPubMedCentralCrossRefGoogle Scholar
  18. Hodgins DC, Shimp L (1995) Identifying adult children of alcoholics: methodological review and a comparison of the CAST-6 with other methods. Addiction 90:255–267. doi: 10.1111/j.1360-0443.1995.tb01043.x PubMedCrossRefGoogle Scholar
  19. Hodgins DC, Maticka-Tyndale E, El-Guebaly N, West M (1993) The CAST-6: development of a short-form of the children of alcoholics screening test. Addict Behav 18:337–345. doi: 10.1016/0306-4603(93)90035-8 PubMedCrossRefGoogle Scholar
  20. Holden CJ, Dennie T, Hicks AD (2013) Assessing the reliability of the M5-120 on Amazon’s mechanical Turk. Comput Human Behav 29:1749–1754. doi: 10.1016/j.chb.2013.02.020 CrossRefGoogle Scholar
  21. Iacono WG, Malone SM, McGue M (2008) Behavioral disinhibition and the development of early-onset addiction: common and specific influences. Annu Rev Clin Psychol 4:325–348. doi: 10.1146/annurev.clinpsy.4.022007.141157 PubMedCrossRefGoogle Scholar
  22. Jarmolowicz DP, Bickel WK, Carter AE, Franck CT, Mueller ET (2012) Using crowdsourcing to examine relations between delay and probability discounting. Behav Process 91:308–312. doi: 10.1016/j.beproc.2012.09.001 CrossRefGoogle Scholar
  23. Johnson PS, Herrmann ES, Johnson MW (2015) Opportunity costs of reward delays and the discounting of hypothetical money and cigarettes. J Exp Anal Behav 103:87–107. doi: 10.1002/jeab.110 PubMedPubMedCentralCrossRefGoogle Scholar
  24. Kidd C, Palmeri H, Aslin RN (2013) Rational snacking: young children’s decision-making on the marshmallow task is moderated by beliefs about environmental reliability. Cognition 126:109–114. doi: 10.1016/j.cognition.2012.08.004 PubMedPubMedCentralCrossRefGoogle Scholar
  25. Kirby KN, Maraković NN (1996) Delay-discounting probabilistic rewards: rates decrease as amounts increase. Psychon Bull Rev 3:100–104. doi: 10.3758/BF03210748 PubMedCrossRefGoogle Scholar
  26. Kirby KN, Petry NM, Bickel WK (1999) Heroin addicts have higher discount rates for delayed rewards than non-drug-using controls. J Exp Psychol Gen 128:78–87PubMedCrossRefGoogle Scholar
  27. MacCallum RC, Zhang S, Preacher KJ, Rucker DD (2002) On the practice of dichotomization of quantitative variables. Psychol Methods 7:19–40. doi: 10.1037/1082-989X.7.1.19 PubMedCrossRefGoogle Scholar
  28. MacKillop J (2013) Integrating behavioral economics and behavioral genetics: delayed reward discounting as an endophenotype for addictive disorders. J Exp Anal Behav 99:14–31. doi: 10.1002/jeab.4 PubMedCrossRefGoogle Scholar
  29. MacKillop J, Amlung MT, Few LR, Ray LA, Sweet LH, Munafó MR (2011) Delayed reward discounting and addictive behavior: a meta-analysis. Psychopharmacology (Berlin) 216:305–321. doi: 10.1007/s00213-011-2229-0 CrossRefGoogle Scholar
  30. McLellan AT, Luborsky L, Woody GE, O’Brien CP (1980) An improved diagnostic evaluation instrument for substance abuse patients. The addiction severity index. J Nerv Ment Dis 168:26–33. doi: 10.1097/00005053-198001000-00006 PubMedCrossRefGoogle Scholar
  31. Mendez IA, Simon NW, Hart N et al (2010) Self-administered cocaine causes long-lasting increases in impulsive choice in a delay discounting task. Behav Neurosci 124:470–477. doi: 10.1037/a0020458 PubMedPubMedCentralCrossRefGoogle Scholar
  32. Mitchell MR, Weiss VG, Ouimet DJ, Fuchs RA, Morgan D, Setlow B (2014) Intake-dependent effects of cocaine self-administration on impulsive choice in a delay discounting task. Behav Neurosci 128:419–429. doi: 10.1037/a0036742 PubMedPubMedCentralCrossRefGoogle Scholar
  33. Moreno M et al (2012) Impulsivity differences in recreational cannabis users and binge drinkers in a university population. Drug Alcohol Depend 124:355–362. doi: 10.1016/j.drugalcdep.2012.02.011 PubMedCrossRefGoogle Scholar
  34. Petry NM, Kirby KN, Kranzler HR (2002) Effects of gender and family history of alcohol dependence on a behavioral task of impulsivity in healthy subjects. J Stud Alcohol 63:83–90PubMedGoogle Scholar
  35. Preacher KJ, Hayes AF (2004) SPSS and SAS procedures for estimating indirect effects in simple mediation models. Behav Res Methods Instrum Comput 36:717–731. doi: 10.3758/BF03206553 PubMedCrossRefGoogle Scholar
  36. Preacher KJ, Hayes AF (2008) Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behav Res Methods 40:879–891. doi: 10.3758/BRM.40.3.879 PubMedCrossRefGoogle Scholar
  37. Romer D (2010) Adolescent risk taking, impulsivity, and brain development: implications for prevention. Dev Psychobiol 52:263–276. doi: 10.1002/dev.20442 PubMedPubMedCentralGoogle Scholar
  38. Saunders JB, Aasland OG, Babor TF et al (1993) Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption-II. Addiction 88:791–804. doi: 10.1111/j.1360-0443.1993.tb02093.x PubMedCrossRefGoogle Scholar
  39. Shopland DR, Hartman AM, Gibson JT, Mueller MD, Kessler LG, Lynn WR (1996) Cigarette smoking among U.S. adults by state and region: estimates from the current population survey. J Natl Cancer Inst 88:1748–1758. doi: 10.1093/jnci/88.23.1748 PubMedCrossRefGoogle Scholar
  40. Sobell LC, Sobell MB (1992) Timeline follow-back: a technique for assessing self-reported alcohol consumption. In: Litten RZ, Allen JP (eds) Measuring alcohol consumption: psychosocial and biological methods. Humana Press, Towota, pp 41–72CrossRefGoogle Scholar
  41. Stein JS, Madden GJ (2013) Delay discounting an drug abuse: empirical, conceptual, and methodological considerations. In: MacKillop J, de Wit H (eds) The Wiley-Blackwell handbook of addiction psychopharmacology. Wiley-Blackwell, Chichester, pp 165–208Google Scholar
  42. Tyrfingsson T, Thorgeirsson TE, Geller F et al (2010) Addictions and their familiality in Iceland. Ann N Y Acad Sci 1187:208–217. doi: 10.1111/j.1749-6632.2009.05151.x PubMedCrossRefGoogle Scholar
  43. World Health Organization (2010) The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST): manual for use in primary care. WHO Press, GenevaGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Lauren VanderBroek
    • 1
  • John Acker
    • 1
  • Abraham A. Palmer
    • 2
    • 3
  • Harriet de Wit
    • 3
  • James MacKillop
    • 1
    • 4
    Email author
  1. 1.Department of PsychologyUniversity of GeorgiaAthensUSA
  2. 2.Department of Human GeneticsUniversity of ChicagoChicagoUSA
  3. 3.Department of Psychiatry and Behavioral NeuroscienceUniversity of ChicagoChicagoUSA
  4. 4.Peter Boris Centre for Addictions Research, Department of Psychiatry and Behavioural NeurosciencesMcMaster University/St. Joseph’s Healthcare HamiltonHamiltonCanada

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