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Psychopharmacology

, Volume 232, Issue 11, pp 1931–1939 | Cite as

Anxiety sensitivity and expectation of arousal differentially affect the respiratory response to caffeine

  • Christiane A. Pané-Farré
  • Manuela G. Alius
  • Christiane Modeß
  • Karen Methling
  • Terry Blumenthal
  • Alfons O. Hamm
Original Investigation

Abstract

Rationale

This study aimed to test how expectations and anxiety sensitivity influence respiratory and autonomic responses to caffeine.

Objectives

The current study investigated the effects of expected vs. unexpected caffeine ingestion in a group of persons prone to the anxiety-provoking effect of caffeine (high anxiety sensitive persons, that is, persons scoring at least one SD above the mean on the Anxiety Sensitivity Index (Peterson and Reiss 1992)) as compared to low-anxious controls.

Methods

Autonomic arousal (heart rate, skin conductance level), respiratory responding (expired CO2, minute ventilation), and subjective report were assessed in high and low anxiety sensitive participants immediately after beverage consumption and at absorption peak (30 min post-consumption) in four separate sessions during which either coffee (expectation of caffeine) or bitter lemon soda (no expectation of caffeine) was crossed with 4 mg/kg caffeine vs. no drug.

Results

High and low anxiety sensitive persons showed comparable autonomic arousal and symptom reports to caffeine which was modulated by expectation, i.e., greater for coffee. Respiratory responding (CO2 decrease, minute ventilation increase) was more accentuated when caffeine was both expected and administered in the low anxiety sensitive group but more accentuated when caffeine was unexpectedly administered in the high anxiety sensitive group. Autonomic arousal and respiratory effects were observable within a few minutes after caffeine administration and were most pronounced at maximum absorption.

Conclusions

The results highlight the modulating role of expectancies in respiratory responding to caffeine in low vs. high anxiety sensitive persons and might have important implications for the better understanding of unexpected panic attacks.

Keywords

Autonomic arousal pCO2 Balanced placebo design Interoceptive challenge 

Notes

Conflict of interest

This study was supported by the Department of Neuroscience at the University of Greifswald, Germany, and by a W. C. Archie Fund grant from Wake Forest University, USA. The authors declare no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Christiane A. Pané-Farré
    • 1
  • Manuela G. Alius
    • 1
  • Christiane Modeß
    • 2
  • Karen Methling
    • 3
  • Terry Blumenthal
    • 4
  • Alfons O. Hamm
    • 1
  1. 1.Department of Physiological and Clinical Psychology/PsychotherapyUniversity of GreifswaldGreifswaldGermany
  2. 2.Department of Clinical PharmacologyUniversity Medicine GreifswaldGreifswaldGermany
  3. 3.Department of BiochemistryUniversity of GreifswaldGreifswaldGermany
  4. 4.Department of PsychologyWake Forest UniversityWinston-SalemUSA

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