Chronic and recreational use of cocaine is associated with a vulnerability to semantic interference
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Language production requires that speakers effectively recruit inhibitory control to successfully produce speech. The use of cocaine is associated with impairments in cognitive control processes in the non-verbal domain, but the impact of chronic and recreational use of cocaine on these processes during language production remains undetermined.
This study aims to observe the possible impairment of inhibitory control in language production among chronic and recreational cocaine polydrug users.
Two experiments were carried out on chronic (experiment 1) and recreational (experiment 2) cocaine polydrug users performing a blocked-cycled naming task, yielding an index of semantic interference. Participants were matched for sex, age, and intelligence (Raven’s Standard Progressive Matrices) with cocaine-free controls, and their performance was compared on the blocked-cycled naming task.
Chronic and recreational users showed significantly larger semantic interference effects than cocaine-free controls, thereby indicating a deficit in the ability to inhibit interfering information.
Evidence indicates a relationship between the consumption of cocaine, even at recreational levels, and the inhibitory processes that suppress the overactive lexical representations in the semantic context. This deficit may be critical in adapting and responding to many real-life situations where an efficient self-monitoring system is necessary for the prevention of errors.
KeywordsCocaine Inhibition Semantic interference Speech
- American Psychological Association APA (2000) Diagnostic and statistical manual of mental disorders, 4th edition: DSM-IV-TR®. American Psychiatric PubGoogle Scholar
- Bolla KI, Eldreth DA, London ED, Kiehl KA, Mouratidis M, Contoreggi C, Matochik JA, Kurian V, Cadet JL, Kimes AS, Funderburk FR, Ernst M (2003) Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task. Neuroimage 19:1085–1094CrossRefPubMedCentralPubMedGoogle Scholar
- Brainerd CJ, Dempster FN (1995) Interference and inhibition in cognition. Academic PressGoogle Scholar
- Colzato LS, van den Wildenberg WPM, Hommel B (2007) Impaired inhibitory control in recreational cocaine users. PLoS ONE 2Google Scholar
- European Monitoring Centre for Drugs and Drug Addiction EMCDDA (2012) 2012 Annual report on the state of the drugs problem in Europe. Publications Office of the European UnionGoogle Scholar
- First MB, Spitzer RL, Gibbon M, Williams JBW (1996) Structured clinical interview for DSM-IV axis I disorders, clinician version (SCID-CV). American Psychiatric Press, Inc, Washington, D.C.Google Scholar
- Hulka LM, Eisenegger C, Preller KH, Vonmoos M, Jenni D, Bendrick K, Baumgartner MR, Seifritz E, Quednow BB (2013a) Altered social and non-social decision-making in recreational and dependent cocaine users. Psychol Med 1–14Google Scholar
- International Center for Alcohol Policies ICAP (2005) ICAP blue book: practical guides for alcohol policy and targeted interventions. ICAP, Washington, DCGoogle Scholar
- Kaplan E, Goodglass H, Weintraub S (1983) Boston naming test. Lea & Febiger, PhiladelphiaGoogle Scholar
- Kelly BC, Parsons JT (2008) Predictors and comparisons of polydrug and non-polydrug cocaine use in club subcultures. 34:774–781Google Scholar
- Martinez D, Greene K, Broft A, Kumar D, Liu F, Narendran R, Slifstein M, Van Heertum R, Kleber HD (2009) Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D2/D3 receptors following acute dopamine depletion. Am J Psychiatry 166:1170–1177CrossRefPubMedCentralPubMedGoogle Scholar
- Raven JC, Court JH, Raven J (1988) Manual for Raven’s progressive matrices and vocabulary scales: standard progressive matrices, r.e. edn. HK LewisGoogle Scholar
- Roelofs A, Piai V (2011) Attentional inhibition in bilingual naming performance: evidence from delta-plot analyses. Front Psychol 2Google Scholar
- Rosenberg DR, Dick EL, O’Hearn KM, Sweeney JA (1997) Response-inhibition deficits in obsessive-compulsive disorder: an indicator of dysfunction in frontostriatal circuits. J Psychiatry Neurosci 22Google Scholar
- Sellaro R, Hommel B, Colzato LS (2013) Increased response conflict in recreational cocaine polydrug users. Exp Brain ResGoogle Scholar
- Shao Z, Meyer AS, Roelofs A (2013) Selective and nonselective inhibition of competitors in picture naming. Mem CognGoogle Scholar
- Spanish Ministry of Health/Ministerio de Sanidad y Consumo (2007) Prevención de los problemas derivados del alcohol 1ª Conferencia de prevención y promoción de la salud en la práctica en España. Ministerio de Sanidad y ConsumoGoogle Scholar
- Tomasi D, Volkow ND, Wang R, Carrillo JH, Maloney T, Alia-Klein N, Woicik PA, Telang F, Goldstein RZ (2010) Disrupted functional connectivity with dopaminergic midbrain in cocaine abusers. PLoS ONE 5Google Scholar
- United Nations Office on Drugs & Crime UNODC (2013) World drug report, 2013. United Nations, New YorkGoogle Scholar
- Verdejo-García AJ, López-Torrecillas F, Aguilar de Arcos F, Pérez-García M (2005) Differential effects of MDMA, cocaine, and cannabis use severity on distinctive components of the executive functions in polysubstance users: a multiple regression analysis. Addict Behav 30:89–101CrossRefPubMedGoogle Scholar
- Volkow ND, Fowler JS, Wang G-J, Telang F, Logan J, Jayne M, Ma Y, Pradhan K, Wong C, Swanson JM (2010) Cognitive control of drug craving inhibits brain reward regions in cocaine abusers. Neuroimage 49Google Scholar
- Vonmoos M, Hulka LM, Preller KH, Jenni D, Baumgartner MR, Stohler R, Bolla KI, Quednow BB (2013) Cognitive dysfunctions in recreational and dependent cocaine users: role of attention-deficit hyperactivity disorder, craving and early age at onset. Br J Psychiatry J Ment Sci 203:35–43CrossRefGoogle Scholar