Determination of psychotropic use in children and adolescents from a prescription database: methodological issues
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We read with great interest the recent article by Hsia et al. (2014), who presented estimated rates of psychopharmacological treatment in individuals with ASD in five European and five non-European countries, based on data from the IMS Prescribing Insights (MIDAS) database, an international commercial prescription database.
We appreciate the efforts of Hsia et al. (2014) to assemble data on psychotropic use in persons with ASD, especially as they have included some countries for which pharmaco-epidemiological data have to date been rarely reported. As literature on psychopharmacological treatment in ASD patients is scarce (overview: Bachmann et al. 2013), this endeavour is to be congratulated.
Nevertheless, we would like to discuss some methodological issues. Generally, the outcomes of pharmaco-epidemiological surveys significantly depend on the methods employed (e.g. Rubin 2013). In our opinion, in the case of the article by Hsia et al. (2014), the methodology used by the...
KeywordsAutism Spectrum Disorder Autism Spectrum Disorder Risperidone Methylphenidate Rett Syndrome
Conflict of interest
Dr Bachmann has received lecture fees from Actelion, Novartis, and Ferring as well as payment from BARMER GEK for writing a chapter in a book. He has served as a study physician in clinical trials for Shire and Novartis. Dr Hoffmann is active on behalf of a number of statutory health-insurance companies (BARMER GEK, DAK, TK and various corporate health-insurance funds) in the setting of contracts for third-party payment.
- Hoffmann F, Bachmann C (2014) Auch bei Kindern und Jugendlichen gibt es Unterschiede in Soziodemographie, Gesundheit und Inanspruchnahme zwischen den Krankenkassenarten [Differences in sociodemographic characteristics, health, and health service use of children and adolescents according to their health insurance funds]. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 57(4):455–463CrossRefGoogle Scholar