, Volume 231, Issue 7, pp 1429–1431 | Cite as

New glutamatergic target for alcohol and substance use disorder medications

  • Csaba VadaszEmail author
  • Mariko Saito

Traditionally, theories of dopamine reward (Wise 1996; Wise and Bozarth 1987) dominated the field of alcohol and substance use disorder. The brain's most abundant neurotransmitter, glutamate, only later emerged as an equally important player (Cornish and Kalivas 2000; Kalivas et al. 2003). Over the past couple of years, several reports in psychopharmacology investigated the role of glutamatergic neurotransmission in the development of alcohol and substance use disorders (Holmes et al. 2013; Newman et al. 2012; von der Goltz et al. 2009).

The latest review in a special issue of psychopharmacology focused on glutamatergic targets for new alcohol medications (Holmes et al. 2013). While the authors provide an informative overview of several components of the glutamate system with established roles in alcohol-related behaviors [the N-methyl-d-aspartate (NMDA) receptor and specific NMDA receptor subunits, the glycine B site on the NMDA receptors, l-alpha-amino-3-hydroxy-5-methyl-isoxazole-4-...


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Nathan Kline Institute, Neurobehavioral GeneticsNew York University School of Medicine, PsychiatryNew YorkUSA

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