Prospective memory impairment in long-term opiate users
Opiate use is associated with a range of neurological and cognitive deficits. However, to date, no studies have assessed whether these cognitive deficits extend to the ability to perform intended actions in the future (i.e. prospective memory). Reduced ability in this area might be anticipated due to impaired executive functions and episodic memory associated with long-term opiate use.
The main objectives of this study are to assess the performance of long-term opiate users on a laboratory measure of prospective memory which closely simulates the types of prospective memory tasks encountered in everyday life (‘Virtual Week’) and to investigate the extent to which prospective memory performance is related to executive functions and episodic memory ability.
Twenty-six long-term heroin users enrolled in an opiate substitution program, and 30 controls with no previous history of drug use were tested on Virtual Week. Retrospective memory and executive functions were also assessed.
Long-term opiate users were significantly impaired on prospective memory performance compared with controls (p = 0.002, η2p = 0.17), and these deficits did not vary as a function of prospective memory task type (regular, irregular, event, time). The findings also suggest that retrospective memory difficulties contribute to the prospective memory difficulties seen in opiate users (rs = 0.78, p < 0.001) but that executive dysfunction is less influential.
Prospective memory is sensitive to long-term opiate use. Importantly, opiate users suffer from generalised deficits in prospective memory, regardless of the task demands, which may have significant implications for day-to-day functioning. These results may therefore contribute to the development of clinical intervention strategies to reduce the negative impact of prospective memory failures in daily life.
KeywordsProspective memory Opiate users Virtual Week Executive functions Retrospective memory
- Australian National Health and Medical Research Council (2001) Australian alcohol guidelines: Health risks and benefits, Commonwealth of Australia, CanberraGoogle Scholar
- Burgess PW, Shallice T (1996) The Hayling and Brixton Tests. Thames Valley Test Company, Bury St Edmonds, EnglandGoogle Scholar
- Cohen J (1988) Statistical power analysis for the behavioral sciences. Lawrence Erlbaum, Hillsdale, NJGoogle Scholar
- De Maeyer J, Vanderplasschen W, Lammertyn J, Nieuwenhuizen C, Sabbe B, Broekaert E (2011) Current quality of life and its determinants among opiate-dependent individuals five years after starting methadone treatment. Qual Life Res 20:139–150. doi:10.1007/s11136-010-9732-3 PubMedCentralPubMedCrossRefGoogle Scholar
- Einstein GO, McDaniel MA (1996) Retrieval processes in prospective memory: theoretical approaches and some new findings. In: Brandimonte MA, Einstein GO, McDaniel MA (eds) Prospective memory: theory and applications. Lawrence Erlbaum, Mahwah, NJ, pp 115–141Google Scholar
- Fabbri M, Tonetti L, Martoni M, Natale V (2013) Sleep and prospective memory. Biol Rhythm Res ahead of print: 1–6Google Scholar
- Fishbein DH, Krupitsky E, Flannery BA, Langevin DJ, Bobashev G, Verbitskaya E, Augustine CB, Bolla KI, Zvartau E, Schech B, Egorova V, Bushara N, Tsoy M (2007) Neurocognitive characterizations of Russian heroin addicts without a significant history of other drug use. Drug Alcohol Depend 90:25–38. doi:10.1016/j.drugalcdep.2007.02.015 PubMedCentralPubMedCrossRefGoogle Scholar
- Grundgeiger T, Bayen UJ, Horn SS (2013) Effects of sleep deprivation on prospective memory. Memory ahead of print: 1–8.Google Scholar
- Lyoo IK, Streeter CC, Ahn KH, Lee HK, Pollack MH, Silveri MM, Nassar L, Levin JM, Sarid-Segal O, Ciraulo DA (2004) White matter hyperintensities in subjects with cocaine and opiate dependence and healthy comparison subjects. Psychiatry Res Neuroimaging 131:135–145. doi:10.1016/j.pscychresns.2004.04.001 CrossRefGoogle Scholar
- Martinez D, Saccone PA, Liu F, Slifstein M, Orlowska D, Grassetti A, Cook S, Broft A, Van Heertum R, Comer SD (2012) Deficits in dopamine D(2) receptors and presynaptic dopamine in heroin dependence: commonalities and differences with other types of addiction. Biol Psychiatry 71:192–198. doi:10.1016/j.biopsych.2011.08.024 PubMedCentralPubMedCrossRefGoogle Scholar
- McDaniel MA, Einstein GO (2000) Strategic and automatic processes in prospective memory retrieval: A multiprocess framework. Applied Cognitive Psychology Special Issue: New perspectives in prospective memory 14: S127-S144. doi: 10.1002/acp.775
- McDaniel MA, Einstein GO (2007) Prospective memory: an overview and synthesis of an emerging field. Sage, Thousand Oaks, CAGoogle Scholar
- Nelson HE (1982) National Adult Reading Test (NART): Test manual. NFER, WindsorGoogle Scholar
- Prosser J, Cohen LJ, Steinfeld M, Eisenberg D, London ED, Galynker II (2006) Neuropsychological functioning in opiate-dependent subjects receiving and following methadone maintenance treatment. Drug Alcohol Depend 84:240–247. doi:10.1016/j.drugalcdep.2006.02.006 PubMedCentralPubMedCrossRefGoogle Scholar
- Rose N, Rendell PG, McDaniel MA, Aberle I, Kliegel M (2010) Age and individual differences in prospective memory during a “Virtual Week”: the roles of working memory, vigilance, task regularity and cue focality. Psychol Aging 25:595–601. doi:10.1037/a0019771 PubMedCentralPubMedCrossRefGoogle Scholar
- Tabachnick B, Fidell L (2007) Using Multivariate Statistics 5edn. Pearson, Boston, MAGoogle Scholar
- United Nations (2012) World drug report. United Nations Office on Drugs and Crime, New YorkGoogle Scholar