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Effects of inhibitory GABA-active neurosteroids on cocaine seeking and cocaine taking in rats

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Abstract

Rationale

Several compounds that potentiate GABA-induced inhibitory currents also decrease stress, anxiety and addiction-related behaviors. Because of the well-established connection between stress and addiction, compounds that reduce stress-induced responses might be efficacious in treating addiction. Since endogenous neurosteroids such as allopregnanolone may function in a manner similar to benzodiazepines to reduce HPA axis activation and anxiety following stressful stimuli, we hypothesized that exogenously applied neurosteroids would reduce cocaine reinforcement in two animal models.

Methods

Male Wistar rats were trained to self-administer cocaine and food under a concurrent alternating operant schedule of reinforcement. Two separate groups of rats were trained to self-administer cocaine or food pellets and were then exposed to similar cue-induced reinstatement paradigms. Both groups of rats were pretreated with various doses of neurosteroids.

Results

Allopregnanolone and 3α-hydroxy-3β-methyl-17β-nitro-5α-androstane (R6305-7, a synthetic neurosteroid) were ineffective in selectively decreasing cocaine relative to food self-administration. On the other hand, both allopregnanolone and R6305-7 significantly decreased the cue-induced reinstatement of extinguished cocaine seeking, confirmed by one-way ANOVA.

Conclusions

These results suggest that neurosteroids may be effective in reducing the relapse to cocaine use without affecting ongoing cocaine self-administration.

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References

  • Agís-Balboa RC, Pinna G, Zhubi A et al (2006) Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc Natl Acad Sci U S A 103:14602–14607

    Article  PubMed Central  PubMed  Google Scholar 

  • Akwa Y, Purdy RH, Koob GF, Britton KT (1999) The amygdala mediates the anxiolytic-like effect of the neurosteroid allopregnanolone in rat. Behav Brain Res 106:119–125

    Article  CAS  PubMed  Google Scholar 

  • Andréen L, Nyberg S, Turkmen S et al (2009) Sex steroid induced negative mood may be explained by the paradoxical effect mediated by GABAA modulators. Psychoneuroendocrinology 34:1121–1132

    Article  PubMed  Google Scholar 

  • Anker JJ, Carroll ME (2010) Sex differences in the effects of allopregnanolone on yohimbine-induced reinstatement of cocaine seeking in rats. Drug Alcohol Depend 107:264–267

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Anker JJ, Larson EB, Gliddon LA, Carroll ME (2007) Effects of progesterone on the reinstatement of cocaine-seeking behavior in female rats. Exp Clin Psychopharmacol 15:472–480

    Article  CAS  PubMed  Google Scholar 

  • Anker JJ, Holtz NA, Zlebnik N, Carroll ME (2009) Effects of allopregnanolone on the reinstatement of cocaine-seeking behavior in male and female rats. Psychopharmacology 203:63–72

    Article  CAS  PubMed  Google Scholar 

  • Bäckström T, Haage D, Löfgren M et al (2011) Paradoxical effects of GABA-A modulators may explain sex steroid induced negative mood symptoms in some persons. Neuroscience 191:46–54

    Article  PubMed  Google Scholar 

  • Barker JL, Harrison NL, Lange GD, Owen DG (1987) Potentiation of gamma-aminobutyric-acid-activated chloride conductance by a steroid anaesthetic in cultured rat spinal neurones. J Physiol 386:485–501

    CAS  PubMed Central  PubMed  Google Scholar 

  • Barrett AC, Negus SS, Mello NK, Caine SB (2005) Effect of GABA agonists and GABA-A receptor modulators on cocaine- and food-maintained responding and cocaine discrimination in rats. J Pharmacol Exp Ther 315(2):858–871

    Article  CAS  PubMed  Google Scholar 

  • Bianchi MT, Haas KF, Macdonald RL (2002) Alpha1 and alpha6 subunits specify distinct desensitization, deactivation and neurosteroid modulation of GABA(A) receptors containing the delta subunit. Neuropharmacology 43(4):492–502

    Article  CAS  PubMed  Google Scholar 

  • Bitran D, Hilvers RJ, Kellogg CK (1991) Anxiolytic effects of 3 alpha-hydroxy-5 alpha[beta]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor. Brain Res 561(1):157–161

    CAS  PubMed  Google Scholar 

  • Campbell UC, Carroll ME (2001) Effects of ketoconazole on the acquisition of intravenous cocaine self-administration under different feeding conditions in rats. Psychopharmacology 154(3):311–318

    Article  CAS  PubMed  Google Scholar 

  • Carroll ME, Meisch RA (1981) Determinants of increased drug self-administration due to food deprivation. Psychopharmacology 74(3):197–200

    Article  CAS  PubMed  Google Scholar 

  • Carter RB, Wood PL, Wieland S et al (1997) Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor. J Pharmacol Exp Ther 280:1284–1295

    CAS  PubMed  Google Scholar 

  • Crawley JN, Glowa JR, Majewska MD, Paul SM (1986) Anxiolytic activity of an endogenous adrenal steroid. Brain Res 398:382–385

    CAS  PubMed  Google Scholar 

  • Deo GS, Dandekar MP, Upadhya MA et al (2010) Neuropeptide Y Y1 receptors in the central nucleus of amygdala mediate the anxiolytic-like effect of allopregnanolone in mice: behavioral and immunocytochemical evidences. Brain Res 1318:77–86

    CAS  PubMed  Google Scholar 

  • Engin E, Treit D (2007) The anxiolytic-like effects of allopregnanolone vary as a function of intracerebral microinfusion site: the amygdala, medial prefrontal cortex, or hippocampus. Behav Pharmacol 18:461–470

    Article  CAS  PubMed  Google Scholar 

  • Feltenstein MW, See RE (2007) Plasma progesterone levels and cocaine-seeking in freely cycling female rats across the estrous cycle. Drug Alcohol Depend 89(2–3):183–189

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Festa ED, Jenab S, Chin J, Gazi FM, Wu HB, Russo SJ, Quinones-Jenab V (2003) Frequency of cocaine administration affects behavioral and endocrine responses in male and female Fischer rats. Cell Mol Biol (Noisy-le-grand) 49(8):1275–1280

    CAS  Google Scholar 

  • Finn DA, Roberts AJ, Long S et al (2003) Neurosteroid consumption has anxiolytic effects in mice. Pharmacol Biochem Behav 76:451–462

    Article  CAS  PubMed  Google Scholar 

  • Fox HC, Hong K-IA, Siedlarz K, Sinha R (2008) Enhanced sensitivity to stress and drug/alcohol craving in abstinent cocaine-dependent individuals compared to social drinkers. Neuropsychopharmacology 33:796–805

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Frye CA (2007) Progestins influence motivation, reward, conditioning, stress, and/or response to drugs of abuse. Pharmacol Biochem Behav 86(2):209–219, Review

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Fuchs RA, Evans KA, Mehta RH et al (2005) Influence of sex and estrous cyclicity on conditioned cue-induced reinstatement of cocaine-seeking behavior in rats. Psychopharmacology 179:662–672

    Article  CAS  PubMed  Google Scholar 

  • Fuchs RA, Feltenstein MW, See RE (2006) The role of the basolateral amygdala in stimulus-reward memory and extinction memory consolidation and in subsequent conditioned cued reinstatement of cocaine seeking. Eur J Neurosci 23:2809–2813

    Article  PubMed  Google Scholar 

  • Gabriele A, See RE (2010) Reversible inactivation of the basolateral amygdala, but not the dorsolateral caudate putamen, attenuates consolidation of cocaine-cue associative learning in a reinstatement model of drug-seeking. Eur J Neurosci 32:1024–1029

    Article  PubMed Central  PubMed  Google Scholar 

  • Goeders NE, Guerin GF (2008) Effects of the combination of metyrapone and oxazepam on cocaine and food self-administration in rats. Pharmacol Biochem Behav 91:181–189

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Goeders NE, Ikemoto S, Dorairaj NR, Simpson ST, Guerin GF (1997) Effects of initial exposure to saline in rats trained under a multiple schedule of food reinforcement and cocaine self-administration. Neurosci Abstr 23:1095

    Google Scholar 

  • Goeders NE, Clampitt DM, Keller C et al (2009) Alprazolam and oxazepam block the cue-induced reinstatement of extinguished cocaine seeking in rats. Psychopharmacology 201:581–588

    Article  CAS  PubMed  Google Scholar 

  • Grobin AC, VanDoren MJ, Porrino LJ, Morrow AL (2005) Cortical 3 alpha-hydroxy-5 alpha-pregnan-20-one levels after acute administration of Delta 9-tetrahydrocannabinol, cocaine and morphine. Psychopharmacology 179:544–550

    Article  CAS  PubMed  Google Scholar 

  • Gulacsi A, Lee CR, Sík A, Viitanen T, Kaila K, Tepper JM, Freund TF (2003) Cell type-specific differences in chloride-regulatory mechanisms and GABA(A) receptor-mediated inhibition in rat substantia nigra. J Neurosci 23(23):8237–8246

    CAS  PubMed  Google Scholar 

  • Hirani K, Sharma AN, Jain NS et al (2005) Evaluation of GABAergic neuroactive steroid 3alpha-hydroxy-5alpha-pregnane-20-one as a neurobiological substrate for the anti-anxiety effect of ethanol in rats. Psychopharmacology 180:267–278

    Article  CAS  PubMed  Google Scholar 

  • Jackson LR, Robinson TE, Becker JB (2006) Sex differences and hormonal influences on acquisition of cocaine self-administration in rats. Neuropsychopharmacology 31(1):129–138

    CAS  PubMed  Google Scholar 

  • Jaworska-Feil L (1998) Opposite effects of inhibitory and excitatory neurosteroids on dopamine release from rat nucleus accumbens. Pol J Pharmacol 50:449–452

    CAS  PubMed  Google Scholar 

  • Kalivas PW (2007) Neurobiology of cocaine addiction: implications for new pharmacotherapy. Am J Addict 16(2):71–78, Review

    Article  PubMed  Google Scholar 

  • Kaminski RM, Gasior M, Carter RB, Witkin JM (2003) Protective efficacy of neuroactive steroids against cocaine kindled-seizures in mice. Eur J Pharmacol 474(2–3):217–222

    Article  CAS  PubMed  Google Scholar 

  • Keller CM, Cornett EM, Guerin GF, Goeders NE (2013) Combinations of oxazepam and metyrapone attenuate cocaine and methamphetamine cue reactivity. Drug Alcohol Depend 133(2):405–412

    Article  CAS  PubMed  Google Scholar 

  • Kerstetter KA, Aguilar VR, Parrish AB, Kippin TE (2008) Protracted time-dependent increases in cocaine-seeking behavior during cocaine withdrawal in female relative to male rats. Psychopharmacol (Berl) 198:63–75

    Article  CAS  Google Scholar 

  • Kippin TE, Fuchs RA, Mehta RH, Case JM, Parker MP, Bimonte-Nelson HA, See RE (2005) Potentiation of cocaine-primed reinstatement of drug seeking in female rats during estrus. Psychopharmacol (Berl) 182(2):245–252

    Article  CAS  Google Scholar 

  • Lan NC, Bolger MB, Gee KW (1991) Identification and characterization of a pregnane steroid recognition site that is functionally coupled to an expressed GABAA receptor. Neurochem Res 16:347–356

    Article  CAS  PubMed  Google Scholar 

  • Larson EB, Anker JJ, Gliddon LA, Fons KS, Carroll ME (2007) Effects of estrogen and progesterone on the escalation of cocaine self-administration in female rats during extended access. Exp Clin Psychopharmacol 15(5):461–471

    Article  CAS  PubMed  Google Scholar 

  • Lee JLC, Milton AL, Everitt BJ (2006) Cue-induced cocaine seeking and relapse are reduced by disruption of drug memory reconsolidation. J Neurosci 26:5881–5887

    Article  CAS  PubMed  Google Scholar 

  • Leśkiewicz M, Budziszewska B, Jaworska-Feil L, Kubera M, Basta-Kaim A, Lasoń W (2003) Inhibitory effect of some neuroactive steroids on cocaine-induced kindling in mice. Pol J Pharmacol 55(6):1131–1136

    PubMed  Google Scholar 

  • Lynch WJ (2008) Acquisition and maintenance of cocaine self-administration in adolescent rats: effects of sex and gonadal hormones. Psychopharmacol (Berl) 197(2):237–246

    Article  CAS  Google Scholar 

  • Lynch WJ, Carroll ME (1999) Sex differences in the acquisition of intravenously self-administered cocaine and heroin in rats. Psychopharmacol (Berl) 144(1):77–82

    Article  CAS  Google Scholar 

  • Mellon SH, Griffin LD, Compagnone NA (2001) Biosynthesis and action of neurosteroids. Brain Res Rev 37:3–12

    Article  CAS  PubMed  Google Scholar 

  • Motzo C, Porceddu ML, Maira G et al (1996) Inhibition of basal and stress-induced dopamine release in the cerebral cortex and nucleus accumbens of freely moving rats by the neurosteroid allopregnanolone. J Psychopharmacol 10:266–272

    Article  CAS  PubMed  Google Scholar 

  • Negus SS, Mello NK, Fivel PA (2000) Effects of GABA agonists and GABA-A receptor modulators on cocaine discrimination in rhesus monkeys. Psychopharmacol (Berl) 152(4):398–407

    Article  CAS  Google Scholar 

  • Niyomchai T, Jenab S, Festa ED, Akhavan A, Quiñones-Jenab V (2006) Effects of short- and long-term estrogen and progesterone replacement on behavioral responses and c-fos mRNA levels in female rats after acute cocaine administration. Brain Res 1126(1):193–199

    CAS  PubMed  Google Scholar 

  • Peltier RL, Guerin GF, Dorairaj N, Goeders NE (2001) Effects of saline substitution on responding and plasma corticosterone in rats trained to self-administer different doses of cocaine. J Pharmacol Exp Ther 299(1):114–120

    CAS  PubMed  Google Scholar 

  • Peris J (1996) Repeated cocaine injections decrease the function of striatal gamma-aminobutyric acid(A) receptors. J Pharmacol Exp Ther 276(3):1002–1008

    CAS  PubMed  Google Scholar 

  • Perrotti LI, Russo SJ, Fletcher H, Chin J, Webb T, Jenab S, Quiñones-Jenab V (2001) Ovarian hormones modulate cocaine-induced locomotor and stereotypic activity. Ann N Y Acad Sci 937:202–216

    Article  CAS  PubMed  Google Scholar 

  • Pillai GV, Smith AJ, Hunt PA, Simpson PB (2004) Multiple structural features of steroids mediate subtype-selective effects on human alpha4beta3delta GABAA receptors. Biochem Pharmacol 68(5):819–831

    Article  CAS  PubMed  Google Scholar 

  • Quinones-Jenab V, Jenab S (2010) Progesterone attenuates cocaine-induced responses. Horm Behav 58(1):22–32

    Article  CAS  PubMed  Google Scholar 

  • Quinones-Jenab V, Perrotti LI, Mc Monagle J, Ho A, Kreek MJ (2000) Ovarian hormone replacement affects cocaine-induced behaviors in ovariectomized female rats. Pharmacol Biochem Behav 67(3):417–422

    Article  CAS  PubMed  Google Scholar 

  • Quinones-Jenab V, Minerly ACE, Niyomchia T et al (2008) Progesterone and allopregnanolone are induced by cocaine in serum and brain tissues of male and female rats. Pharmacol Biochem Behav 89:292–297

    Article  CAS  PubMed  Google Scholar 

  • Quinton MS, Gerak LR, Moerschbaecher JM, Winsauer PJ (2006) Effects of pregnanolone in rats discriminating cocaine. Pharmacol Biochem Behav 85:385–392

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Reddy DS, Rogawski MA (2002) Stress-induced deoxycorticosterone-derived neurosteroids modulate GABA(A) receptor function and seizure susceptibility. J Neurosci 22(9):3795–3805

    CAS  PubMed  Google Scholar 

  • Roberts DC, Koob GF (1982) Disruption of cocaine self-administration following 6-hydroxydopamine lesions of the ventral tegmental area in rats. Pharmacol Biochem Behav 17(5):901–904

    Article  CAS  PubMed  Google Scholar 

  • Roberts DC, Koob GF, Klonoff P, Fibiger HC (1980) Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens. Pharmacol Biochem Behav 12(5):781–787

    Article  CAS  PubMed  Google Scholar 

  • Roberts DC, Bennett SA, Vickers GJ (1989) The estrous cycle affects cocaine self-administration on a progressive ratio schedule in rats. Psychopharmacol (Berl) 98(3):408–411

    Article  CAS  Google Scholar 

  • Rodgers RJ, Johnson NJ (1998) Behaviorally selective effects of neuroactive steroids on plus-maze anxiety in mice. Pharmacol Biochem Behav 59(1):221–232

    Article  CAS  PubMed  Google Scholar 

  • Romieu P, Martin-Fardon R, Bowen WD, Maurice T (2003) Sigma 1 receptor-related neuroactive steroids modulate cocaine-induced reward. J Neurosci 23:3572–3576

    CAS  PubMed  Google Scholar 

  • Romieu P, Lucas M, Maurice T (2006) Sigma1 receptor ligands and related neuroactive steroids interfere with the cocaine-induced state of memory. Neuropsychopharmacology 31:1431–1443

    Article  CAS  PubMed  Google Scholar 

  • Roth ME, Carroll ME (2004) Sex differences in the escalation of intravenous cocaine intake following long- or short-access to cocaine self-administration. Pharmacol Biochem Behav 78(2):199–207

    Article  CAS  PubMed  Google Scholar 

  • Runyon SP, Orr M, Navarro HA et al (2009) 17beta-Nitro-5alpha-androstan-3alpha-ol and its 3beta-methyl derivative: neurosteroid analogs with potent anticonvulsant and anxiolytic activities. Eur J Pharmacol 617:68–73

    Article  CAS  PubMed  Google Scholar 

  • Rupprecht R (2003) Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties. Psychoneuroendocrinology 28:139–168

    Article  CAS  PubMed  Google Scholar 

  • Rupprecht R, Holsboer F (1999) Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives. Trends Neurosci 22:410–416

    Article  CAS  PubMed  Google Scholar 

  • Russo SJ, Festa ED, Fabian SJ, Gazi FM, Kraish M, Jenab S, Quiñones-Jenab V (2003) Gonadal hormones differentially modulate cocaine-induced conditioned place preference in male and female rats. Neuroscience 120(2):523–533

    Article  CAS  PubMed  Google Scholar 

  • See RE (2002) Neural substrates of conditioned-cued relapse to drug-seeking behavior. Pharmacol Biochem Behav 71(3):517–529

    Article  CAS  PubMed  Google Scholar 

  • Shen H, Gong QH, Aoki C et al (2007) Reversal of neurosteroid effects at alpha4beta2delta GABAA receptors triggers anxiety at puberty. Nat Neurosci 10:469–477

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Shirayama Y, Muneoka K, Fukumoto M et al (2011) Infusions of allopregnanolone into the hippocampus and amygdala, but not into the nucleus accumbens and medial prefrontal cortex, produce antidepressant effects on the learned helplessness rats. Hippocampus 21:1105–1113

    Article  CAS  PubMed  Google Scholar 

  • Sinha R, Talih M, Malison R et al (2003) Hypothalamic-pituitary-adrenal axis and sympatho-adreno-medullary responses during stress-induced and drug cue-induced cocaine craving states. Psychopharmacology 170:62–72

    Article  CAS  PubMed  Google Scholar 

  • Sinha R, Garcia M, Paliwal P et al (2006) Stress-induced cocaine craving and hypothalamic-pituitary-adrenal responses are predictive of cocaine relapse outcomes. Arch Gen Psychiatry 63:324–331

    Article  PubMed  Google Scholar 

  • Smith SS (1994) Female sex steroid hormones: from receptors to networks to performance—actions on the sensorimotor system. Prog Neurobiol 44(1):55–86, Review

    Article  CAS  PubMed  Google Scholar 

  • Sofuoglu M, Kosten TR (2006) Emerging pharmacological strategies in the fight against cocaine addiction. Expert Opin Emerg Drugs 11(1):91–98, Review

    Article  CAS  PubMed  Google Scholar 

  • Sundström I, Bäckström T, Wang M et al (1999) Premenstrual syndrome, neuroactive steroids and the brain. Gynecol Endocrinol Off J Int Soc Gynecol Endocrinol 13:206–220

    Google Scholar 

  • Ugale RR, Sharma AN, Kokare DM et al (2007) Neurosteroid allopregnanolone mediates anxiolytic effect of etifoxine in rats. Brain Res 1184:193–201

    CAS  PubMed  Google Scholar 

  • Uzunova V, Ceci M, Kohler C et al (2003) Region-specific dysregulation of allopregnanolone brain content in the olfactory bulbectomized rat model of depression. Brain Res 976:1–8

    CAS  PubMed  Google Scholar 

  • Vanover KE, Suruki M, Huber M, Wilent WB, Carter RB (2000) Neuroactive steroids attenuate cocaine-induced sucrose intake in rats, but not cocaine-induced hyperactivity in mice. Psychopharmacol (Berl) 149(3):269–276

    Article  CAS  Google Scholar 

  • Vocci F, Ling W (2005) Medications development: successes and challenges. Pharmacol Ther 108(1):94–108

    Article  CAS  PubMed  Google Scholar 

  • Volkow ND, Wang G-J, Telang F et al (2006) Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction. J Neurosci 26:6583–6588

    Article  CAS  PubMed  Google Scholar 

  • Wang C, Marx CE, Morrow AL et al (2007) Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: a role for NMDA receptors. Neurosci Lett 415:118–123

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Weerts EM, Froestl W, Griffiths RR (2005) Effects of GABAergic modulators on food and cocaine self-administration in baboons. Drug Alcohol Depend 80(3):369–376

    Article  CAS  PubMed  Google Scholar 

  • Wieland S, Lan NC, Mirasedeghi S, Gee KW (1991) Anxiolytic activity of the progesterone metabolite 5 alpha-pregnan-3 alpha-o1-20-one. Brain Res 565(2):263–268

    CAS  PubMed  Google Scholar 

  • Wieland S, Belluzzi JD, Stein L, Lan NC (1995) Comparative behavioral characterization of the neuroactive steroids 3 alpha-OH,5 alpha-pregnan-20-one and 3 alpha-OH,5 beta-pregnan-20-one in rodents. Psychopharmacology 118:65–71

    Article  CAS  PubMed  Google Scholar 

  • Wilson MA, Biscardi R (1997) Influence of gender and brain region on neurosteroid modulation of GABA responses in rats. Life Sci 60:1679–1691

    Article  CAS  PubMed  Google Scholar 

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Research was financially supported by institutional funding from the Department of Pharmacology, Toxicology & Neuroscience and Research Triangle Institute.

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The authors have no conflicts of interest to declare.

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Authors and Affiliations

  1. Department of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Sciences Center, 1501 Kings Highway, Box 33932, Shreveport, LA, 71130, USA

    Christopher D. Schmoutz & Nicholas E. Goeders

  2. Organic and Medicinal Chemistry, Research Triangle Institute, 3040 Cornwallis Drive, Research Triangle Park, NC, 27709, USA

    Scott P Runyon

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  1. Christopher D. Schmoutz
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  2. Scott P Runyon
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Correspondence to Christopher D. Schmoutz.

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Schmoutz, C.D., Runyon, S.P. & Goeders, N.E. Effects of inhibitory GABA-active neurosteroids on cocaine seeking and cocaine taking in rats. Psychopharmacology 231, 3391–3400 (2014). https://doi.org/10.1007/s00213-013-3404-2

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