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Examining the effects of initial smoking abstinence on response to smoking-related stimuli and response inhibition in a human laboratory model

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Abstract

Rationale

Research is needed on initial smoking abstinence and relapse risk.

Objective

This study aims to investigate the effects of different durations of initial abstinence on sensitivity to smoking-related stimuli and response inhibition in the context of a larger battery of outcome measures.

Methods

Smokers were randomly assigned to receive payment contingent on smoking abstinence across all 15 study days (15C) or just the final 2 days (2C). Smoking status and subject ratings were assessed daily. Participants completed fMRI sessions at baseline and day 14 during which they completed craving ratings after exposure to smoking-related and neutral stimuli and performed a response inhibition task. On day 15, participants completed a smoking preference session involving 20 exclusive choices between smoking and money.

Results

The payment contingencies were effective in producing greater smoking abstinence in the 15C vs. 2C conditions. Ratings of withdrawal decreased, while ratings of ease and confidence in abstaining increased in the 15C vs. 2C conditions across the 15-day study. 15C participants were less likely to choose the smoking option in the preference session. 15C participants reported greater reductions in craving compared to the 2C participants in the presence of smoking-related and neutral stimuli (i.e., decreases in generalized craving), but no differences were noted in cue reactivity per se or in response inhibition.

Conclusions

Results systematically replicate prior observations that a period 2 weeks of initial abstinence decreases the relative reinforcing effects of smoking and improves other outcomes associated with relapse risk compared to the initial day or two of a cessation effort, and extends them by underscoring the importance of generalized rather than cue-induced craving in relation to relapse risk during the initial weeks of smoking cessation.

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Acknowledgments

This research was supported by research grant R01DA008076 and training grant T32DA07242 from the National Institute on Drug Abuse and center grant P20GM103644 from the National Institute of General Medical Sciences.

Conflict of interest

No conflicts of interest to report.

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Authors and Affiliations

  1. Department of Psychiatry, University of Vermont, Burlington, VT, USA

    Matthew P. Bradstreet, Stephen T. Higgins, Alexa A. Lopez & Marie A. Parry

  2. Department of Psychology, University of Vermont, Burlington, VT, USA

    Matthew P. Bradstreet, Stephen T. Higgins & Alexa A. Lopez

  3. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA

    F. Joseph McClernon & Rachel V. Kozink

  4. Department of Medical Biostatistics, University of Vermont, Burlington, VT, USA

    Joan M. Skelly

  5. The Treatment Research Institute, Philadelphia, PA, USA

    Yukiko Washio

Authors
  1. Matthew P. Bradstreet
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  2. Stephen T. Higgins
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  4. Rachel V. Kozink
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  7. Alexa A. Lopez
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Corresponding author

Correspondence to Stephen T. Higgins.

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Bradstreet, M.P., Higgins, S.T., McClernon, F.J. et al. Examining the effects of initial smoking abstinence on response to smoking-related stimuli and response inhibition in a human laboratory model. Psychopharmacology 231, 2145–2158 (2014). https://doi.org/10.1007/s00213-013-3360-x

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  • DOI: https://doi.org/10.1007/s00213-013-3360-x

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