Skip to main content
SpringerLink
Log in

Effect of fendiline on the maintenance and expression of methamphetamine-induced conditioned place preference in Sprague–Dawley rats

  • Original Investigation
  • Published:
Psychopharmacology Aims and scope Submit manuscript

Abstract

Rationale

Fendiline is a GABAB receptor-positive allosteric modulator and L-type Ca2+ channel blocker that is safe for human use. Based on these pharmacological properties, fendiline may be useful to disrupt associative memories that can drive relapse to drug use in drug-addicted individuals

Objective

The current study evaluated the potential of fendiline to inhibit the maintenance and expression of learned associations between methamphetamine (meth) and an environmental context using conditioned place preference (CPP) in rats, to model for the associative learning that occurs during drug abuse by humans

Methods

Following meth conditioning (1 mg/kg), fendiline (5 mg/kg) was administered at various post-conditioning times to ascertain if there was a temporal window during which fendiline would be effective.

Results

Two once-daily injections of fendiline did not influence the maintenance of CPP regardless of the post-conditioning treatment time while 10 once-daily fendiline treatments inhibited CPP maintenance (p < 0.05). Fendiline administered immediately prior to the CPP test inhibited expression of meth-induced CPP in rats with a fendiline treatment history of 10 once-daily injections (p < 0.05) or those that received two injections that corresponded to the last 2 days of the 10-day treatment (p < 0.05). Fendiline did not produce preference or aversion on its own, nor did it alter motivated motor behavior.

Conclusion

Maintenance and expression of meth CPP is mitigated by repeated fendiline treatments when administered during the days that precede CPP testing. Reduction in the significance of meth-associated cues can reduce relapse; therefore, fendiline may be of value for addiction therapy in abstinent, meth-addicted humans.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  • Alberini CM, Milekic MH, Tronel S (2006) Mechanisms of memory stabilization and de-stabilization. Cell Mol Life Sci 63:999–1008

    Article  PubMed  CAS  Google Scholar 

  • Ameisen O (2005) Complete and prolonged suppression of symptoms and consequences of alcohol-dependence using high-dose baclofen: a self-case report of a physician. Alcohol Alcohol 40:147–150

    Article  PubMed  CAS  Google Scholar 

  • Arai S, Takuma K, Mizoguchi H, Ibi D, Nagai T, Kamei H, Kim HC, Yamada K (2009) GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice. Eur J Pharmacol 602:101–104

    Article  PubMed  CAS  Google Scholar 

  • Bailey CH, Kandel ER, Si K (2004) The persistence of long-term memory: a molecular approach to self-sustaining changes in learning-induced synaptic growth. Neuron 44:49–57

    Article  PubMed  CAS  Google Scholar 

  • Bartoletti M, Gubellini C, Ricci F, Gaiardi M (2004) The GABAB agonist baclofen blocks the expression of sensitisation to the locomotor stimulant effect of amphetamine. Behav Pharmacol 15:397–401

    Article  PubMed  CAS  Google Scholar 

  • Bartoletti M, Gubellini C, Ricci F, Gaiardi M (2005) Baclofen blocks the development of sensitization to the locomotor stimulant effect of amphetamine. Behav Pharmacol 16:553–558

    Article  PubMed  CAS  Google Scholar 

  • Bayer R, Mannhold R (1987) Fendiline: a review of its basic pharmacological and clinical properties. Pharmatherapeutica 5:103–136

    PubMed  CAS  Google Scholar 

  • Berke JD, Hyman SE (2000) Addiction, dopamine, and the molecular mechanisms of memory. Neuron 25:515–532

    Article  PubMed  CAS  Google Scholar 

  • Biala G (2003) Calcium channel antagonists suppress nicotine-induced place preference and locomotor sensitization in rodents. Pol J Pharmacol 55:327–335

    PubMed  CAS  Google Scholar 

  • Biala G, Budzynska B (2008) Calcium-dependent mechanisms of the reinstatement of nicotine-conditioned place preference by drug priming in rats. Pharmacol Biochem Behav 89:116–125

    Article  PubMed  CAS  Google Scholar 

  • Biala G, Kruk-Slomka M, Jozwiak K (2013) Influence of acute or chronic calcium channel antagonists on the acquisition and consolidation of memory and nicotine-induced cognitive effects in mice. Naunyn Schmiedebergs Arch Pharmacol 386:651–664

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Bowery NG (1993) GABAB receptor pharmacology. Annu Rev Pharmacol Toxicol 33:109–147

    Article  PubMed  CAS  Google Scholar 

  • Brebner K, Childress AR, Roberts DC (2002) A potential role for GABA(B) agonists in the treatment of psychostimulant addiction. Alcohol Alcohol 37:478–484

    Article  PubMed  CAS  Google Scholar 

  • Brebner K, Ahn S, Phillips AG (2005) Attenuation of d-amphetamine self-administration by baclofen in the rat: behavioral and neurochemical correlates. Psychopharmacology (Berlin) 177:409–417

    Article  CAS  Google Scholar 

  • Brenhouse HC, Andersen SL (2008) Delayed extinction and stronger reinstatement of cocaine conditioned place preference in adolescent rats, compared to adults. Behav Neurosci 122:460–465

    Article  PubMed  CAS  Google Scholar 

  • Brown EE, Robertson GS, Fibiger HC (1992) Evidence for conditional neuronal activation following exposure to a cocaine-paired environment: role of forebrain limbic structures. J Neurosci 12:4112–4121

    PubMed  CAS  Google Scholar 

  • Calcagnetti DJ, Schechter MD (1994) Nicotine place preference using the biased method of conditioning. Prog Neuropsychopharmacol Biol Psychiatry 18:925–933

    Article  PubMed  CAS  Google Scholar 

  • Castellano C, Brioni JD, Nagahara AH, McGaugh JL (1989) Post-training systemic and intra-amygdala administration of the GABA-B agonist baclofen impairs retention. Behav Neural Biol 52:170–179

    Article  PubMed  CAS  Google Scholar 

  • Chappell WR, Mordenti J (1991) Extrapolation of toxicological and pharmacological data from animals to humans. In: Testa B (ed) Drug Research. Academic Press, New York, pp 1–116

    Google Scholar 

  • Chen Y, Phillips K, Minton G, Sher E (2005) GABA(B) receptor modulators potentiate baclofen-induced depression of dopamine neuron activity in the rat ventral tegmental area. Br J Pharmacol 144:926–932

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Childress AR, Mozley PD, McElgin W, Fitzgerald J, Reivich M, O’Brien CP (1999) Limbic activation during cue-induced cocaine craving. Am J Psychiatry 156:11–18

    PubMed  CAS  PubMed Central  Google Scholar 

  • Childress AR, Ehrman RN, Wang Z, Li Y, Sciortino N, Hakun J, Jens W, Suh J, Listerud J, Marquez K, Franklin T, Langleben D, Detre J, O’Brien CP (2008) Prelude to passion: limbic activation by “unseen” drug and sexual cues. PLoS One 3:e1506

    Article  PubMed  PubMed Central  Google Scholar 

  • Childs E, de Wit H (2009) Amphetamine-induced place preference in humans. Biol Psychiatry 65:900–904

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Cousins MS, Stamat HM, de Wit H (2001) Effects of a single dose of baclofen on self-reported subjective effects and tobacco smoking. Nicotine Tob Res 3:123–129

    Article  PubMed  CAS  Google Scholar 

  • Cryan JF, Kelly PH, Chaperon F, Gentsch C, Mombereau C, Lingenhoehl K, Froestl W, Bettler B, Kaupmann K, Spooren WP (2004) Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N′-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines. J Pharmacol Exp Ther 310:952–963

    Article  PubMed  CAS  Google Scholar 

  • Cunningham CL, Ferree NK, Howard MA (2003) Apparatus bias and place conditioning with ethanol in mice. Psychopharmacology (Berl) 170:409–422

    Article  CAS  Google Scholar 

  • de Macedo GC, Kawakami SE, Vignoli T, Sinigaglia-Coimbra R, Suchecki D (2013) The influence of orexins on ethanol-induced behavioral sensitization in male mice. Neurosci Lett. doi:10.1016/j.neulet.2013.07.010:

    PubMed  Google Scholar 

  • DeMarco A, Dalal RM, Pai J, Aquilina SD, Mullapudi U, Hammel C, Kothari SK, Kahanda M, Liebling CN, Patel V, Schiffer WK, Brodie JD, Dewey SL (2009) Racemic gamma vinyl-GABA (R, S-GVG) blocks methamphetamine-triggered reinstatement of conditioned place preference. Synapse 63:87–94

    Article  PubMed  CAS  Google Scholar 

  • Ehrman RN, Robbins SJ, Childress AR, O’Brien CP (1992) Conditioned responses to cocaine-related stimuli in cocaine abuse patients. Psychopharmacology (Berl) 107:523–529

    Article  CAS  Google Scholar 

  • Fattore L, Spano MS, Cossu G, Scherma M, Fratta W, Fadda P (2009) Baclofen prevents drug-induced reinstatement of extinguished nicotine-seeking behaviour and nicotine place preference in rodents. Eur Neuropsychopharmacol 19:487–498

    Article  PubMed  CAS  Google Scholar 

  • Filip M, Frankowska M (2007) Effects of GABA(B) receptor agents on cocaine priming, discrete contextual cue and food induced relapses. Eur J Pharmacol 571:166–173

    Article  PubMed  CAS  Google Scholar 

  • Filip M, Frankowska M, Przegalinski E (2007) Effects of GABA(B) receptor antagonist, agonists and allosteric positive modulator on the cocaine-induced self-administration and drug discrimination. Eur J Pharmacol 574:148–157

    Article  PubMed  CAS  Google Scholar 

  • Ford KA, Wolf ME, Hu XT (2009) Plasticity of L-type Ca2+ channels after cocaine withdrawal. Synapse 63:690–697

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Frankowska M, Wydra K, Faron-Gorecka A, Zaniewska M, Kusmider M, Dziedzicka-Wasylewska M, Filip M (2008) Neuroadaptive changes in the rat brain GABA(B) receptors after withdrawal from cocaine self-administration. Eur J Pharmacol 599:58–64

    Article  PubMed  CAS  Google Scholar 

  • Gjoni T, Urwyler S (2008) Receptor activation involving positive allosteric modulation, unlike full agonism, does not result in GABAB receptor desensitization. Neuropharmacology 55:1293–1299

    Article  PubMed  CAS  Google Scholar 

  • Gjoni T, Desrayaud S, Imobersteg S, Urwyler S (2006) The positive allosteric modulator GS39783 enhances GABA(B) receptor-mediated inhibition of cyclic AMP formation in rat striatum in vivo. J Neurochem 96:1416–1422

    Article  PubMed  CAS  Google Scholar 

  • Guo N, Garcia MM, Harlan RE (2008) A morphine-paired environment alters c-Fos expression in the forebrain of rats displaying conditioned place preference or aversion. Behav Neurosci 122:1078–1086

    Article  PubMed  Google Scholar 

  • Halbout B, Quarta D, Valerio E, Heidbreder CA, Hutcheson DM (2011) The GABA-B positive modulator GS39783 decreases psychostimulant conditioned-reinforcement and conditioned-reward. Addict Biol 16:416–427

    Article  PubMed  CAS  Google Scholar 

  • Haney M, Hart CL, Foltin RW (2006) Effects of baclofen on cocaine self-administration: opioid- and nonopioid-dependent volunteers. Neuropsychopharmacology 31:1814–1821

    Article  PubMed  CAS  Google Scholar 

  • Herrold AA, Voigt RM, Napier TC (2013) mGluR5 is necessary for maintenance of methamphetamine-induced associative learning. Eur Neuropsychopharmacol 23:691–696

    Article  PubMed  CAS  Google Scholar 

  • Hotsenpiller G, Wolf ME (2002) Extracellular glutamate levels in prefrontal cortex during the expression of associative responses to cocaine related stimuli. Neuropharmacology 43:1218–1229

    Article  PubMed  CAS  Google Scholar 

  • Hotsenpiller G, Giorgetti M, Wolf ME (2001) Alterations in behaviour and glutamate transmission following presentation of stimuli previously associated with cocaine exposure. Eur J Neurosci 14:1843–1855

    Article  PubMed  CAS  Google Scholar 

  • Hu XT (2007) Cocaine withdrawal and neuro-adaptations in ion channel function. Mol Neurobiol 35:95–112

    Article  PubMed  CAS  Google Scholar 

  • Jayaram P, Steketee JD (2005) Effects of cocaine-induced behavioural sensitization on GABA transmission within rat medial prefrontal cortex. Eur J Neurosci 21:2035–2039

    Article  PubMed  Google Scholar 

  • Kelley AE (2004) Memory and addiction: shared neural circuitry and molecular mechanisms. Neuron 44:161–179

    Article  PubMed  CAS  Google Scholar 

  • Kerr DI, Ong J, Puspawati NM, Prager RH (2002) Arylalkylamines are a novel class of positive allosteric modulators at GABA(B) receptors in rat neocortex. Eur J Pharmacol 451:69–77

    Article  PubMed  CAS  Google Scholar 

  • Kilts CD, Gross RE, Ely TD, Drexler KP (2004) The neural correlates of cue-induced craving in cocaine-dependent women. Am J Psychiatry 161:233–241

    Article  PubMed  Google Scholar 

  • Kozlovskii VL (1997) The relationship between anticonvulsant and anti-anxiety effects of calcium channel blockers. Eksp Klin Farmakol 60:19–22

    PubMed  CAS  Google Scholar 

  • Kozlovskii VL, Mosin AE, Ivakina LV (1996) The effect of the subchronic administration of calcium-channel blockers on CNS excitability. Eksp Klin Farmakol 59:14–16

    PubMed  CAS  Google Scholar 

  • Kukovetz WR, Brunner F, Beubler E, Weyhenmeyer R, Lohaus R, Grob M, Mayer D (1982) Single dose pharmacokinetics of fendiline in humans. Eur J Drug Metab Pharmacokinet 7:105–110

    Article  PubMed  CAS  Google Scholar 

  • Kurokawa K, Mizuno K, Ohkuma S (2012) Possible involvement of type 1 inositol 1,4,5-trisphosphate receptors up-regulated by dopamine D1 and D2 receptors in mouse nucleus accumbens neurons in the development of methamphetamine-induced place preference. Neuroscience 227:22–29

    Article  PubMed  CAS  Google Scholar 

  • Kushner SA, Unterwald EM (2001) Chronic cocaine administration decreases the functional coupling of GABA(B) receptors in the rat ventral tegmental area as measured by baclofen-stimulated 35S-GTPgammaS binding. Life Sci 69:1093–1102

    Article  PubMed  CAS  Google Scholar 

  • Li SM, Yin LL, Ren YH, Pan LS, Zheng JW (2001) GABA(B) receptor agonist baclofen attenuates the development and expression of d-methamphetamine-induced place preference in rats. Life Sci 70:349–356

    Article  PubMed  CAS  Google Scholar 

  • Lobina C, Carai MA, Froestl W, Mugnaini C, Pasquini S, Corelli F, Gessa GL, Colombo G (2011) Activation of the GABA(B) receptor prevents nicotine-induced locomotor stimulation in mice. Front Psychiatry 2:76

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Maksimenko EI, Zaitsev AA, Ailamazian EK, Ignatov I, Mikhailov AA (1997) Comparison of the tocolytic and hemodynamic effects of calcium channel blockers in pregnant rats. Eksp Klin Farmakol 60:25–27

    PubMed  CAS  Google Scholar 

  • Martin-Iverson MT, Reimer AR (1994) Effects of nimodipine and/or haloperidol on the expression of conditioned locomotion and sensitization to cocaine in rats. Psychopharmacology (Berl) 114:315–320

    Article  CAS  Google Scholar 

  • Masur J, dos Santos HM (1988) Response variability of ethanol-induced locomotor activation in mice. Psychopharmacology (Berl) 96:547–550

    Article  CAS  Google Scholar 

  • McDaid J, Graham MP, Napier TC (2006) Methamphetamine-induced sensitization differentially alters pCREB and DeltaFosB throughout the limbic circuit of the mammalian brain. Mol Pharmacol 70:2064–2074

    Article  PubMed  CAS  Google Scholar 

  • McGregor C, Srisurapanont M, Jittiwutikarn J, Laobhripatr S, Wongtan T, White JM (2005) The nature, time course and severity of methamphetamine withdrawal. Addiction 100:1320–1329

    Article  PubMed  Google Scholar 

  • Mizoguchi H, Yamada K (2011) Pharmacologic treatment with GABA(B) receptor agonist of methamphetamine-induced cognitive impairment in mice. Curr Neuropharmacol 9:109–112

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Mott DD, Lewis DV (1994) The pharmacology and function of central GABAB receptors. Int Rev Neurobiol 36:97–223

    Article  PubMed  CAS  Google Scholar 

  • Nasif FJ, Hu XT, White FJ (2005) Repeated cocaine administration increases voltage-sensitive calcium currents in response to membrane depolarization in medial prefrontal cortex pyramidal neurons. J Neurosci 25:3674–3679

    Article  PubMed  CAS  Google Scholar 

  • Nawrath H, Klein G, Rupp J, Wegener JW, Shainberg A (1998) Open state block by fendiline of L-type Ca++ channels in ventricular myocytes from rat heart. J Pharmacol Exp Ther 285:546–552

    PubMed  CAS  Google Scholar 

  • Nestler EJ (2001) Molecular basis of long-term plasticity underlying addiction. Nat Rev Neurosci 2:119–128

    Article  PubMed  CAS  Google Scholar 

  • Nomikos GG, Spyraki C (1988) Cocaine-induced place conditioning: importance of route of administration and other procedural variables. Psychopharmacology (Berlin) 94:119–125

    Article  CAS  Google Scholar 

  • Nordahl TE, Salo R, Natsuaki Y, Galloway GP, Waters C, Moore CD, Kile S, Buonocore MH (2005) Methamphetamine users in sustained abstinence: a proton magnetic resonance spectroscopy study. Arch Gen Psychiatry 62:444–452

    Article  PubMed  Google Scholar 

  • Ong J, Kerr DI (2005) Clinical potential of GABAB receptor modulators. CNS Drug Rev 11:317–334

    Article  PubMed  CAS  Google Scholar 

  • Ong J, Parker DA, Marino V, Kerr DI, Puspawati NM, Prager RH (2005) 3-Chloro,4-methoxyfendiline is a potent GABA(B) receptor potentiator in rat neocortical slices. Eur J Pharmacol 507:35–42

    Article  PubMed  CAS  Google Scholar 

  • Paolone G, Botreau F, Stewart J (2009) The facilitative effects of D-cycloserine on extinction of a cocaine-induced conditioned place preference can be long lasting and resistant to reinstatement. Psychopharmacology (Berlin) 202:403–409

    Article  CAS  Google Scholar 

  • Paterson NE, Vlachou S, Guery S, Kaupmann K, Froestl W, Markou A (2008) Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in rats. J Pharmacol Exp Ther 326:306–314

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Porrino LJ, Hampson RE, Opris I, Deadwyler SA (2013) Acute cocaine induced deficits in cognitive performance in rhesus macaque monkeys treated with baclofen. Psychopharmacology (Berlin) 225:105–114

    Article  CAS  Google Scholar 

  • Ranaldi R, Poeggel K (2002) Baclofen decreases methamphetamine self-administration in rats. Neuroreport 13:1107–1110

    Article  PubMed  CAS  Google Scholar 

  • Rebec GV, Sun W (2005) Neuronal substrates of relapse to cocaine-seeking behavior: role of prefrontal cortex. J Exp Anal Behav 84:653–666

    Article  PubMed  PubMed Central  Google Scholar 

  • Rezayof A, Ghandipour M, Nazari-Serenjeh F (2012) Effect of co-injection of arachydonilcyclopropylamide and ethanol on conditioned place preference in rats. Physiol Behav 107:301–308

    Article  PubMed  CAS  Google Scholar 

  • Rhodes JS, Ryabinin AE, Crabbe JC (2005) Patterns of brain activation associated with contextual conditioning to methamphetamine in mice. Behav Neurosci 119:759–771

    Article  PubMed  CAS  Google Scholar 

  • Rose ME, Grant JE (2008) Pharmacotherapy for methamphetamine dependence: a review of the pathophysiology of methamphetamine addiction and the theoretical basis and efficacy of pharmacotherapeutic interventions. Ann Clin Psychiatry 20:145–155

    Article  PubMed  Google Scholar 

  • Shoptaw S, Yang X, Rotheram-Fuller EJ, Hsieh YC, Kintaudi PC, Charuvastra VC, Ling W (2003) Randomized placebo-controlled trial of baclofen for cocaine dependence: preliminary effects for individuals with chronic patterns of cocaine use. J Clin Psychiatry 64:1440–1448

    Article  PubMed  CAS  Google Scholar 

  • Simon SL, Dean AC, Cordova X, Monterosso JR, London ED (2010) Methamphetamine dependence and neuropsychological functioning: evaluating change during early abstinence. J Stud Alcohol Drugs 71:335–344

    PubMed  PubMed Central  Google Scholar 

  • Smith MA, Yancey DL, Morgan D, Liu Y, Froestl W, Roberts DC (2004) Effects of positive allosteric modulators of the GABAB receptor on cocaine self-administration in rats. Psychopharmacology (Berlin) 173:105–111

    Article  CAS  Google Scholar 

  • Steiner MA, Lecourt H, Strasser DS, Brisbare-Roch C, Jenck F (2011) Differential effects of the dual orexin receptor antagonist almorexant and the GABA(A)-alpha1 receptor modulator zolpidem, alone or combined with ethanol, on motor performance in the rat. Neuropsychopharmacology 36:848–856

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Suzuki T, Shiozaki Y, Masukawa Y, Misawa M (1992) Effects of calcium antagonists on the cocaine- and methamphetamine-induced conditioned place preference. Arukoru Kenkyuto Yakubutsu Ison 27:81–90

    PubMed  CAS  Google Scholar 

  • Swartzwelder HS, Tilson HA, McLamb RL, Wilson WA (1987) Baclofen disrupts passive avoidance retention in rats. Psychopharmacology (Berlin) 92:398–401

    Article  CAS  Google Scholar 

  • Tripathi O, Schreibmayer W, Tritthart HA (1993) Fendiline inhibits L-type calcium channels in guinea-pig ventricular myocytes: a whole-cell patch-clamp study. Br J Pharmacol 108:865–869

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Tzschentke TM (1998) Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues. Prog Neurobiol 56:613–672

    Article  PubMed  CAS  Google Scholar 

  • Urwyler S, Gjoni T, Kaupmann K, Pozza MF, Mosbacher J (2004) Selected amino acids, dipeptides and arylalkylamine derivatives do not act as allosteric modulators at GABAB receptors. Eur J Pharmacol 483:147–153

    Article  PubMed  CAS  Google Scholar 

  • Urwyler S, Gjoni T, Koljatic J, Dupuis DS (2005) Mechanisms of allosteric modulation at GABAB receptors by CGP7930 and GS39783: effects on affinities and efficacies of orthosteric ligands with distinct intrinsic properties. Neuropharmacology 48:343–353

    Article  PubMed  CAS  Google Scholar 

  • US Department of Health and Human Services (2005) Guidance for industry on estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers. p 42346

  • Voigt RM, Herrold AA, Napier TC (2011a) Baclofen facilitates the extinction of methamphetamine-induced conditioned place preference in rats. Behav Neurosci 125:261–267

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Voigt RM, Herrold AA, Riddle JL, Napier TC (2011b) Administration of GABA(B) receptor positive allosteric modulators inhibit the expression of previously established methamphetamine-induced conditioned place preference. Behav Brain Res 216:419–423

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Wang H, Hu Y, Tsien JZ (2006) Molecular and systems mechanisms of memory consolidation and storage. Prog Neurobiol 79:123–135

    Article  PubMed  CAS  Google Scholar 

  • Weyhenmeyer R, Fenzl E, Apecechea M, Rehm KD, Dyde CJ, Johnson KJ, Friedel R (1987) Tolerance and pharmacokinetics of oral fendiline. Arzneimittelforschung 37:58–62

    PubMed  CAS  Google Scholar 

  • Xi ZX, Gardner EL (2008) Hypothesis-driven medication discovery for the treatment of psychostimulant addiction. Curr Drug Abuse Rev 1:303–327

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Yu YJ, Chang CH, Gean PW (2013) AMPA receptor endocytosis in the amygdala is involved in the disrupted reconsolidation of methamphetamine-associated contextual memory. Neurobiol Learn Mem 103:72–81

    Article  PubMed  CAS  Google Scholar 

  • Zarrindast MR, Shamsi T, Azarmina P, Rostami P, Shafaghi B (2004) GABAergic system and imipramine-induced impairment of memory retention in rats. Eur Neuropsychopharmacol 14:59–64

    Article  PubMed  CAS  Google Scholar 

  • Zhang K, Tarazi FI, Campbell A, Baldessarini RJ (2000) GABA(B) receptors: altered coupling to G-proteins in rats sensitized to amphetamine. Neuroscience 101:5–10

    Article  PubMed  CAS  Google Scholar 

  • Zhang Y, Loonam TM, Noailles PA, Angulo JA (2001) Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions. Ann N Y Acad Sci 937:93–120

    Article  PubMed  CAS  Google Scholar 

  • Zombeck JA, Chen GT, Johnson ZV, Rosenberg DM, Craig AB, Rhodes JS (2008) Neuroanatomical specificity of conditioned responses to cocaine versus food in mice. Physiol Behav 93:637–650

    Article  PubMed  CAS  Google Scholar 

  • Zorick T, Nestor L, Miotto K, Sugar C, Hellemann G, Scanlon G, Rawson R, London ED (2010) Withdrawal symptoms in abstinent methamphetamine-dependent subjects. Addiction 105:1809–1818

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Author notes

  1. Robin M. Voigt

    Present address: Department of Internal Medicine, Section of Gastroenterology, Rush University Medical Center, Cohn Research Building, 1735 W Harrison St, Suite 258C, Chicago, IL, 60612, USA

Authors and Affiliations

  1. Department of Pharmacology, Rush University Medical Center, Cohn Research Building, 1735 W Harrison St., Suite #424, Chicago, IL, 60612, USA

    Robin M. Voigt, Jennifer L. Riddle & T. Celeste Napier

  2. Rush University Medical Center, Cohn Research Building, 1735 W Harrison St, Suite 424, Chicago, IL, 60612, USA

    T. Celeste Napier

  3. Center for Compulsive Behavior and Addiction, Rush University Medical Center, 1735 W Harrison Street, Cohn Research Building Suite 463, Chicago, IL, 60612, USA

    Robin M. Voigt, Jennifer L. Riddle & T. Celeste Napier

  4. Department of Psychiatry, Rush University Medical Center, Cohn Research Building, 1735 W Harrison St., Suite #424, Chicago, IL, 60612, USA

    T. Celeste Napier

Authors
  1. Robin M. Voigt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jennifer L. Riddle
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. Celeste Napier
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to T. Celeste Napier.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Voigt, R.M., Riddle, J.L. & Napier, T.C. Effect of fendiline on the maintenance and expression of methamphetamine-induced conditioned place preference in Sprague–Dawley rats. Psychopharmacology 231, 2019–2029 (2014). https://doi.org/10.1007/s00213-013-3347-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00213-013-3347-7

Keywords

Search

Navigation