Depression, impulsiveness, sleep, and memory in past and present polydrug users of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)
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Ecstasy (3,4-methylenedioxymethamphetamine, MDMA) is a worldwide recreational drug of abuse. Unfortunately, the results from human research investigating its psychological effects have been inconsistent.
The present study aimed to be the largest to date in sample size and 5HT-related behaviors; the first to compare present ecstasy users with past users after an abstinence of 4 or more years, and the first to include robust controls for other recreational substances.
A sample of 997 participants (52 % male) was recruited to four control groups (non-drug (ND), alcohol/nicotine (AN), cannabis/alcohol/nicotine (CAN), non-ecstasy polydrug (PD)), and two ecstasy polydrug groups (present (MDMA) and past users (EX-MDMA). Participants completed a drug history questionnaire, Beck Depression Inventory, Barratt Impulsiveness Scale, Pittsburgh Sleep Quality Index, and Wechsler Memory Scale-Revised which, in total, provided 13 psychometric measures.
While the CAN and PD groups tended to record greater deficits than the non-drug controls, the MDMA and EX-MDMA groups recorded greater deficits than all the control groups on ten of the 13 psychometric measures. Strikingly, despite prolonged abstinence (mean, 4.98; range, 4–9 years), past ecstasy users showed few signs of recovery. Compared with present ecstasy users, the past users showed no change for ten measures, increased impairment for two measures, and improvement on just one measure.
Given this record of impaired memory and clinically significant levels of depression, impulsiveness, and sleep disturbance, the prognosis for the current generation of ecstasy users is a major cause for concern.
KeywordsMDMA Ecstasy Present users Past users Prolonged abstinence Depression Impulsiveness Sleep Memory Long-lasting deficits
The authors declare no conflict of interest and no sources of external funding. The study formed part of a PhD thesis submitted by LT and supervised by CC and GS.
- Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd edn. Erlbaum, HillsdaleGoogle Scholar
- Daumann J Jr, Fischermann T, Heekeren K, Thron A, Gouzoulis-Mayfrank E (2004) Neural mechanisms of working memory in ecstasy (MDMA) users who continue or discontinue ecstasy and amphetamine use: evidence from an 18-month longitudinal functional magnetic resonance imaging study. Biol Psychiatry 56:349–355PubMedCrossRefGoogle Scholar
- EMCDDA (2012) 2012 Annual Report of the State of the Drugs Problem in Europe. European Monitoring Centre for Drugs and Drug Addiction, Lisbon, November 2012. http://www.emcdda.europa.eu/publications/annual-report/2012. Accessed 18 Feb 2013
- Kirilly E (2010) Long-term neuronal damage and recovery after a single dose of MDMA: expression and distribution of serotonin transporter in the rat brain. Neuropsychopharmacology (Hung) 12:413–423Google Scholar
- Rogers G, Elston J, Garside R, Roome C, Taylor R, Younger P et al (2009) The harmful health effects of recreational ecstasy: a systematic review of observational evidence. Health Technol Assess 13:1–315, iii-iv, ix-xiiGoogle Scholar
- Taurah LS (2011) The acute and long lasting psychological effects of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy'): a cohort study conducted during the period 2002–2007. Ph.D. thesis. London Metropolitan University.Google Scholar
- Wechsler D (1987) Wechsler Memory Scale-Revised Manual. Psychological Corporation, San Antonio, TXGoogle Scholar