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Methamphetamine-induced increases in putamen gray matter associate with inhibitory control

Abstract

Rationale

Problematic drug use is associated with difficulty in exerting self-control over behaviors, and this difficulty may be a consequence of atypical morphometric characteristics that are exhibited by drug-experienced individuals. The extent to which these structural abnormalities result from drug use or reflect neurobiological risk factors that predate drug use, however, is unknown.

Objectives

The purpose of this study is to determine how methamphetamine affects corticostriatal structure and how drug-induced changes relate to alterations in inhibitory control.

Methods

Structural magnetic resonance images and positron emission tomography (PET) scans, assessing dopamine D2-like receptor and transporter availability, were acquired in monkeys trained to acquire, retain, and reverse three-choice visual discrimination problems before and after exposure to an escalating dose regimen of methamphetamine (or saline, as a control). Voxel-based morphometry was used to compare changes in corticostriatal gray matter between methamphetamine- and saline-exposed monkeys. The change in gray matter before and after the dosing regimen was compared to the change in the behavioral performance and in dopaminergic markers measured with PET.

Results

Methamphetamine exposure, compared to saline, increased gray matter within the right putamen. These changes were positively correlated with changes in performance of methamphetamine-exposed monkeys in the reversal phase, and were negatively correlated with alterations in D2-like receptor and DAT availability.

Conclusions

The results provide the first evidence that exposure to a methamphetamine dosing regimen that resembles human use alters the structural integrity of the striatum and that gray-matter abnormalities detected in human methamphetamine users are due, at least in part, to the pharmacological effects of drug experience.

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Acknowledgments

This study was supported primarily by Public Health Service grants P20-DA022539, R03-DA020598, T32-DA024635, F31-DA028812, and F31-DA033117 with additional support from the Consortium for Neuropsychiatric Phenomics at UCLA. The Consortium is funded by PHS grants UL1-DE019580 and RL1-MH083270.

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Correspondence to James David Jentsch.

Additional information

Stephanie M. Groman and Angelica M. Morales contributed equally to this work.

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Groman, S.M., Morales, A.M., Lee, B. et al. Methamphetamine-induced increases in putamen gray matter associate with inhibitory control. Psychopharmacology 229, 527–538 (2013). https://doi.org/10.1007/s00213-013-3159-9

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Keywords

  • Gray matter
  • Striatum
  • Prefrontal cortex
  • Inhibitory control
  • Methamphetamine
  • Addiction
  • Dopamine