Psychopharmacology

, Volume 230, Issue 2, pp 261–266 | Cite as

Compensation predicts smoking cessation failure

  • Raymond S. Niaura
  • Jennifer L. Pearson
  • David B. Abrams
Original Investigation

Abstract

Rationale

Compensation is a potential result of decreasing the available nicotine and tar dose in cigarettes. There is little published data linking compensation with cessation.

Objectives

We sought to examine whether compensation in response to restricted cigarette yield is associated with difficulty quitting smoking.

Methods

Questionnaires and blood samples were collected from 174 smokers interested in quitting smoking as part of a larger smoking cessation study. Participants were instructed to use a filter designed to remove 50 % of tar and nicotine from the cigarette but otherwise smoke normally. Participants returned after 3 days of using the filter for follow-up data collection.

Results

Nicotine levels and cigarettes per day decreased after use of the filter. Baseline nicotine and change in nicotine pre/post filter use, but not cigarettes per day or change in cigarettes per day were associated with smoking abstinence at 30 days.

Conclusions

Smokers who demonstrate sensitivity to the biological or behavioral consequences of decreased nicotine content in tobacco smoke have greater difficulty quitting. These findings suggest the need for personalized cessation treatment linked to behavioral compensation.

Keywords

Smoking cessation Nicotine Compensation 

References

  1. Abrams DB, Orleans CT, Niaura RS, Goldstein MG, Prochaska JO, Velicer W (1996) Integrating individual and public health perspectives for treatment of tobacco dependence under managed health care: a combined stepped-care and matching model. Ann Behav Med 18(4):290–304. doi:10.1007/BF02895291 PubMedCrossRefGoogle Scholar
  2. Benowitz NL, Kuyt F, Jacob P (1982) Circadian blood nicotine concentrations during cigarette smoking. Clin Pharmacol Ther 32(6):758–764. doi:10.1038/clpt.1982.233 PubMedCrossRefGoogle Scholar
  3. Benowitz NL, Jacob P, Herrera B (2006) Nicotine intake and dose response when smoking reduced-nicotine content cigarettes. Clin Pharmacol Ther 80(6):703–714. doi:10.1016/j.clpt.2006.09.007 PubMedCrossRefGoogle Scholar
  4. Benowitz NL, Hall SM, Stewart S, Wilson M, Dempsey D, Jacob P (2007) Nicotine and carcinogen exposure with smoking of progressively reduced nicotine content cigarette. Cancer Epidemiol Biomarkers 16(11):2479–2485. doi:10.1158/1055-9965.epi-07-0393 CrossRefGoogle Scholar
  5. Donny EC, Houtsmuller E, Stitzer ML (2007) Smoking in the absence of nicotine: behavioral, subjective and physiological effects over 11 days. Addiction 102(2):324–334. doi:10.1111/j.1360-0443.2006.01670.x PubMedCrossRefGoogle Scholar
  6. Fagerström KO (1978) Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. Addict Behav 3(3–4):235–241. doi:10.1037/1064-1297.9.4.355 PubMedCrossRefGoogle Scholar
  7. Friedman LS, Lichtenstein E, Biglan A (1985) Smoking onset among teens: an empirical analysis of initial situations. Addict Behav 10(1):1–13. doi:10.1016/0306-4603(85)90048-6 PubMedCrossRefGoogle Scholar
  8. Harris AC, Pentel PR, LeSage MG (2009) Correlates of individual differences in compensatory nicotine self-administration in rats following a decrease in nicotine unit dose. Psychopharmacology 205(4):599–611. doi:10.1007/s00213-009-1567-7 PubMedCrossRefGoogle Scholar
  9. Hatsukami DK, Kotlyar M, Hertsgaard, Hecht SS et al (2010) Reduced nicotine content cigarettes: effects on toxicant exposure, dependence and cessation. Addiction 105(2):343–355. doi:10.1111/j.1360-0443.2009.02780.x PubMedCrossRefGoogle Scholar
  10. Institute of Medicine (2007) Ending the tobacco problem: a blueprint for the nation. National Academies Press, Washington, DCGoogle Scholar
  11. Kozlowski LT, Herman CP (1984) The interaction of psychosocial and biological determinants of tobacco use: more on the boundary model. J Appl Soc Psychol 14(3):244–256. doi:10.1111/j.1559-1816.1984.tb02234.x CrossRefGoogle Scholar
  12. MacQueen DA, Heckman BW, Blank MD, Janse Van Rensburg K, Evans DE, Drobes DJ (2012) Transient compensatory smoking in response to placebo cigarettes. Psychopharmacology. doi:10.1007/s00213-012-2685-1 PubMedGoogle Scholar
  13. Niaura R, Shadel WG, Abrams DB, Goldstein MG, Hutchison K (2001) Individual differences in responses to the first cigarette following overnight abstinence in regular smokers. Nicotine Tob Res 3(1):37–44. doi:10.1080/14622200124231 PubMedCrossRefGoogle Scholar
  14. Patterson F, Benowitz N, Shields P, Lerman C et al (2003) Individual differences in nicotine intake per cigarette. Cancer Epidemiol Biomarkers 12(5):468–471. doi:10.1093/ntr/ntq166 Google Scholar
  15. Pomerleau OF, Collins AC, Shiffman S, Pomerleau CS (1993) Why some people smoke and others do not: new perspectives. J Consult Clin Psychol 61(5):723. doi:10.1037/0022-006X.61.5.723 PubMedCrossRefGoogle Scholar
  16. SAS Institute Inc (2012) JMP, version 9 [Computer Software]. SAS Institute Inc., CaryGoogle Scholar
  17. Scherer G (1999) Smoking behaviour and compensation: a review of the literature. Psychopharmacology 145(1):1–20. doi:10.1007/s002130051027 PubMedCrossRefGoogle Scholar
  18. Strasser AA, Lerman C, Sanborn PM, Pickworth WB, Feldman EA (2007) New lower nicotine cigarettes can produce compensatory smoking and increased carbon monoxide exposure. Drug Alcohol Depend 86(2–3):294–300. doi:10.1016/j.drugalcdep.2006.06.017 PubMedCrossRefGoogle Scholar
  19. Sutton SR, Feyerabend C, Cole PV, Russell MA (1978) Adjustment of smokers to dilution of tobacco smoke by ventilated cigarette holders. Clin Pharmacol Ther 24(4):395–405PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Raymond S. Niaura
    • 1
    • 2
    • 3
  • Jennifer L. Pearson
    • 1
  • David B. Abrams
    • 1
    • 2
    • 3
  1. 1.The Schroeder Institute for Tobacco Research and Policy Studies at LegacyWashingtonUSA
  2. 2.Department of Health, Behavior and SocietyJohns Hopkins Bloomberg School of Public HealthBaltimoreUSA
  3. 3.Georgetown University Medical Center Lombardi Comprehensive Cancer CenterWashingtonUSA

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