Abstract
Rationale
Most studies of the reinforcing effects of stimulants have focused on the drugs’ capacity to induce positive mood (i.e., euphoria). However, recent findings suggest drugs may also alter emotional reactivity to external stimuli, and that this may occur independently of direct effects on mood.
Objectives
We aimed to examine effects of d-amphetamine, a prototypic stimulant, on self-reported and psychophysiological reactivity to emotional stimuli as well as overall subjective mood. We predicted that amphetamine would enhance reactivity to pleasant stimuli, particularly, stimuli with social content and that these effects would be independent of the drug’s direct effects on mood.
Methods
Over three sessions, 36 healthy normal adults received placebo, d-amphetamine 10 and 20 mg under counterbalanced double-blind conditions. At each session, emotional reactivity to standardized positive, neutral, and negative pictures with and without social content was measured in self-reports and facial muscles sensitive to emotional state. Drug effects on cardiovascular variables and subjective mood were also measured.
Results
Amphetamine produced euphoria, feelings of drug effect, and increased blood pressure. Most notably, amphetamine enhanced self-reported positive reactions to all pictures and psychophysiological reactions to positive pictures. These effects were not significantly related to drug-induced mood changes. Contrary to our hypothesis, effects of amphetamine on emotional reactivity were not moderated by social content.
Conclusions
This study demonstrates a previously unexamined and potentially reinforcing effect of stimulant drugs in humans, distinct from more typically measured euphorigenic effects, and suggests new areas of research in stimulant abuse risk and adaptations occurring during drug dependence.
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Notes
IAPS numbers for each subset, followed by IAPS normative mean valence (V, 1 = extremely unpleasant–9 = extremely pleasant) and arousal (A, 1 = extremely unarousing–9 = extremely arousing) ratings: Set 1 social/negative = 6,022, 9,421, 2,053, 9,424, 4,621, 9,584, 2,694, 9,045, 9,594, V = 3.03, A = 5.13; Set 1 nonsocial/negative = 9,560, 9,911, 9,320, 9,180, 1,274, 9,373, 7,360, 1,280, 9,010, V = 3.08, A = 5.08; Set 1 social/neutral = 2,272, 9,700, 2,704, 2,595, 2,397, 2,580, 7,620, V = 5.15, A = 3.86; Set 1 nonsocial/neutral = 7,211, 1,935, 7,055, 7,233, 7,207, 5,920, 7,182, 7,830, 7,285, V = 5.12, A = 4.00; Set 1 social/positive = 4,598, 8,467, 8,600, 8,116, 4,601, 2,391, 2,216, 7,502, 8,420, V = 6.99, A = 5.32; Set 1 nonsocial/positive = 1,640, 7,352, 5,991, 7,410, 5,450, 7,508, 5,260, 5,700, 8,170, V = 6.94, 5.20; Set 2 social/negative = 9,420, 9,903, 6,838, 2,700, 6,562, 3,216, 2,312, 3,280, 9,926, V = 3.12, A = 5.18; Set 2 nonsocial/negative = 9,301, 7,380, 9,561, 9,630, 9,621, 1,111, 1,220, 9,440, 9,390, V = 3.07, A = 5.25; Set 2 social/neutral = 8,010, 3,210, 8,475, 2,393, 4,605, 2,485, 2,593, 2,606, 7,496, V = 5.28, A = 4.40; Set 2 nonsocial/neutral = 9,472, 7,054, 5,510, 1,616, 7,242, 7,500, 5,395, 7,283, 5,661, V = 5.11, A = 3.81; Set 2 social/positive = 2,594, 4,625, 9,156, 8,371, 2,373, 4,599, 2,345, 8,210, 8,496, V = 6.92, A = 5.24; Set 2 nonsocial/positive = 7,289, 7,450, 1,660, 5,849, 8,500, 1,540, 5,660, 7,270, 5,480, V = 6.92, A = 5.12; Set 3 social/negative = 6,212, 2,141, 9,425, 2,455, 2,691, 6,561, 6,836, 2,718, 4,635, V = 3.04, A = 5.15; Set 3 nonsocial/negative = 9,140, 9,300, 9,620, 9,290, 9,470, 9,471, 9,008, 9,480, 9,110, V = 3.00, A = 5.05; Set 3 social/neutral = 2,695, 9,582, 9,913, 9,411, 4,000, 2,396, 2,850, 2,579, 2,435, V = 4.84, A = 4.18; Set 3 nonsocial/neutral = 5,120, 7,590, 7,037, 7,100, 7,546, 7,190, 7,183, 1,313, 1,947, V = 5.25, A = 3.73; Set 3 social/positive = 2,605, 4,606, 2,358, 2,344, 4,624, 4,650, 2,352, 4,626, 8,499, V = 6.93, A = 5.14; Set 3 nonsocial/positive = 1,661, 7,284, 7,481, 8,162, 8,531, 7,480, 7,260, 8,502, 5,600, V = 6.92, A = 4.89.
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Acknowledgements
The authors thank Dr. John Cacioppo and his staff at the University of Chicago Center for Cognitive and Social Neuroscience for assistance with design and technical issues, and Cassandra Esposito, Celina Joos, and Megan Leino for their work on this study. The National Institute on Drug Abuse supported this work through grant R01 DA02812 to Dr. Harriet de Wit. Dr. Margaret Wardle is supported by a National Institute on Drug Abuse Training grant, T32 DA007255.
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Wardle, M.C., de Wit, H. Effects of amphetamine on reactivity to emotional stimuli. Psychopharmacology 220, 143–153 (2012). https://doi.org/10.1007/s00213-011-2498-7
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DOI: https://doi.org/10.1007/s00213-011-2498-7