Caffeine exerts positive effects on cognitive and behavioral processes, especially in sub-optimal conditions when arousal is low. Apart from caffeine, coffee contains other compounds including the phenolic compounds ferulic acid, caffeic acid, and the chlorogenic acids, which have purported antioxidant properties. The chlorogenic acids are the most abundant family of compounds found in coffee, yet their effects on cognition and mood have not been investigated.
This study aims to ascertain whether a coffee rich in chlorogenic acid modulates brain function.
The present pilot study examined the acute effects of decaffeinated coffee with regular chlorogenic acid content and decaffeinated coffee with high chlorogenic acid content on mood and cognitive processes, as measured by behavioral tasks and event-related potentials (ERPs). Performance and ERP responses to a battery of cognitive tasks were recorded at baseline and following the equivalent of three cups of coffee in a randomized, double-blind, crossover study of 39 healthy older participants.
Compared with the decaffeinated coffee with regular chlorogenic acid and placebo, caffeinated coffee showed a robust positive effect on higher-level mood and attention processes. To a lesser extent, the decaffeinated coffee high in chlorogenic acid also improved some mood and behavioral measures, relative to regular decaffeinated coffee.
Our pilot results suggest that non-caffeine compounds in coffee such as the chlorogenic acids may be capable of exerting some acute behavioral effects, thus warranting further investigation.
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Note that Caffeinated Coffee increased the CRVAS ‘Relaxed’ scores relative to Placebo but not Regular CGA Decaf. This may suggest that CGA played a role in this improvement. However, as High did not differ from Regular CGA Decaf on this metric, this argues against CGA playing a role in that finding.
Bond A, Lader M (1974) The use of analogue scales in rating subjective feelings. Br J Psychol 47:211–218
Bouayed J, Rammal H, Dicko A, Younos C, Soulimani R (2007) Chlorogenic acid, a polyphenol from Prunus domestica (Mirabelle), with coupled anxiolytic and antioxidant effects. J Neurol Sci 262:77–84
Chu YF, Brown PH, Lyle BJ, Chen Y, Black RM, Williams CE, Lin YC, Hsu CW, Cheng IH (2009) Roasted coffees high in lipophilic antioxidants and chlorogenic acid lactones are more neuroprotective than green coffees. J Agric Food Chem 57:9801–9808
Croft RJ, Barry RJ (2000) Removal of ocular artifact from the EEG: a review. Neurophysiol Clin 30:5–19
de Paulis T, Schmidt DE, Bruchey AK, Kirby MT, McDonald MP, Commers P, Lovinger DM, Martin PR (2002) Dicinnamoylquinides in roasted coffee inhibit the human adenosine transporter. Eur J Pharmacol 442:215–223
Eimer M, Holmes A (2007) Event-related brain potential correlates of emotional face processing. Neuropsychologia 45:15–31
Ekman P, Friesen W (1976) Pictures of facial affect. Consulting Psychologists Press, Consulting Psychologists Press
Esposito E, Rotilio D, Di Matteo V, Di Giulio C, Cacchio M, Algeri S (2002) A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes. Neurobiol Aging 23:719–735
Evers EA, Tillie DE, van der Veen FM, Lieben CK, Jolles J, Deutz NE, Schmitt JA (2005) Effects of a novel method of acute tryptophan depletion on plasma tryptophan and cognitive performance in healthy volunteers. Psychopharmacology (Berl) 178:92–99
Faridi Z, Njike VY, Dutta S, Ali A, Katz DL (2008) Acute dark chocolate and cocoa ingestion and endothelial function: a randomized controlled crossover trial. Am J Clin Nutr 88:58–63
Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198
Frewer LJ, Lader M (1991) The effects of caffeine on two computerized tests of attention and vigilance. Human Psychopharmacology 6:119–128
Gilbert DG, Sugai C, Zuo Y, Rabinovich NE, McClernon FJ, Froeliger B (2007) Brain indices of nicotine's effects on attentional bias to smoking and emotional pictures and to task-relevant targets. Nicotine Tob Res 9:351–363
Gomez-Ruiz JA, Leake DS, Ames JM (2007) In vitro antioxidant activity of coffee compounds and their metabolites. Journal of Agricultural and Food Chemistry 55:6962–6969
Hammes J (1973) The Stroop Color–Word Test: Manual. The Netherlands, Swets & Zeitlinger
Han J, Miyamae Y, Shigemori H, Isoda H (2010) Neuroprotective effect of 3,5-di-O-caffeoylquinic acid on SH-SY5Y cells and senescence-accelerated-prone mice 8 through the up-regulation of phosphoglycerate kinase-1. Neuroscience 169:1039–1045
Haskell CF, Kennedy DO, Wesnes KA, Scholey AB (2005) Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine. Psychopharmacology (Berl) 179:813–825
Haskell CF, Kennedy DO, Milne AL, Wesnes KA, Scholey AB (2008) The effects of l-theanine, caffeine and their combination on cognition and mood. Biol Psychol 77:113–122
Huang YX, Luo YJ (2006) Temporal course of emotional negativity bias: an ERP study. Neurosci Lett 398:91–96
Humphreys MS, Revelle W (1984) Personality, motivation, and performance: a theory of the relationship between individual differences and information processing. Psychol Rev 91:153–184
Hur JY, Soh Y, Kim BH, Suk K, Sohn NW, Kim HC, Kwon HC, Lee KR, Kim SY (2001) Neuroprotective and neurotrophic effects of quinic acids from Aster scaber in PC12 cells. Biol Pharm Bull 24:921–924
Jones GM, Sahakian BJ, Levy R, Warburton DM, Gray JA (1992) Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in Alzheimer's disease. Psychopharmacology (Berl) 108:485–494
Kennedy DO, Scholey AB (2004) A glucose-caffeine 'energy drink' ameliorates subjective and performance deficits during prolonged cognitive demand. Appetite 42:331–333
Kennedy DO, Wightman EL, Reay JL, Lietz G, Okello EJ, Wilde A, Haskell CF (2010) Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. Am J Clin Nutr 91:1590–1597
Kerestes R, Labuschagne I, Croft RJ, O'Neill BV, Bhagwagar Z, Phan KL, Nathan PJ (2009) Evidence for modulation of facial emotional processing bias during emotional expression decoding by serotonergic and noradrenergic antidepressants: an event-related potential (ERP) study. Psychopharmacology (Berl) 202:621–634
Kim SS, Park RY, Jeon HJ, Kwon YS, Chun W (2005) Neuroprotective effects of 3,5-dicaffeoylquinic acid on hydrogen peroxide-induced cell death in SH-SY5Y cells. Phytother Res 19:243–245
Koelega HS (1993) Stimulant drugs and vigilance performance: a review. Psychopharmacology (Berl) 111:1–16
Kono Y, Kashine S, Yoneyama T, Sakamoto Y, Matsui Y, Shibata H (1998) Iron chelation by chlorogenic acid as a natural antioxidant. Biosci Biotechnol Biochem 62:22–27
Kwon SH, Lee HK, Kim JA, Hong SI, Kim HC, Jo TH, Park YI, Lee CK, Kim YB, Lee SY, Jang CG (2010) Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice. Eur J Pharmacol 649:210–217
Labuschagne I, Croft R, Phan K, Nathan P (2010) Augmenting serotonin neurotransmission with citalopram modulates emotional expression decoding but not structural encoding of moderate intensity sad facial emotional stimuli: an event-related potential (ERP) investigation. J Psychopharmacol 24:1153–1164
Lapchak PA (2007) The phenylpropanoid micronutrient chlorogenic acid improves clinical rating scores in rabbits following multiple infarct ischemic strokes: synergism with tissue plasminogen activator. Exp Neurol 205:407–413
Leung S, Croft RJ, O'Neill BV, Nathan PJ (2008) Acute high-dose glycine attenuates mismatch negativity (MMN) in healthy human controls. Psychopharmacology (Berl) 196:451–460
Näätänen R (1992) Attention and brain function. Lawrence Erlbaum Associates, Lawrence Erlbaum Associates
Nardini M, Cirillo E, Natella F, Scaccini C (2002) Absorption of phenolic acids in humans after coffee consumption. J Agric Food Chem 50:5735–5741
Natella F, Nardini M, Giannetti I, Dattilo C, Scaccini C (2002) Coffee drinking influences plasma antioxidant capacity in humans. J Agric Food Chem 50:6211–6216
Nathan PJ, Tanner S, Lloyd J, Harrison B, Curran L, Oliver C, Stough C (2004) Effects of a combined extract of Ginkgo biloba and Bacopa monniera on cognitive function in healthy humans. Hum Psychopharmacol 19:91–96
Olthof MR, Hollman PC, Katan MB (2001) Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr 131:66–71
Pellegrini N, Serafini M, Colombi B, Del Rio D, Salvatore S, Bianchi M, Brighenti F (2003) Total antioxidant capacity of plant foods, beverages and oils consumed in Italy assessed by three different in vitro assays. J Nutr 133:2812–2819
Polich J (2007) Updating P300: an integrative theory of P3a and P3b. Clin Neurophysiol 118:2128–2148
Ramassamy C (2006) Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets. European Journal of Pharmacology 545:51–64
Rees K, Allen D, Lader M (1999) The influences of age and caffeine on psychomotor and cognitive function. Psychopharmacology (Berl) 145:181–188
Renouf M, Guy PA, Marmet C, Fraering AL, Longet K, Moulin J, Enslen M, Barron D, Dionisi F, Cavin C, Williamson G, Steiling H (2010a) Measurement of caffeic and ferulic acid equivalents in plasma after coffee consumption: small intestine and colon are key sites for coffee metabolism. Mol Nutr Food Res 54:760–766
Renouf M, Marmet C, Guy P, Fraering AL, Longet K, Moulin J, Enslen M, Barron D, Cavin C, Dionisi F, Rezzi S, Kochhar S, Steiling H, Williamson G (2010b) Nondairy creamer, but not milk, delays the appearance of coffee phenolic acid equivalents in human plasma. J Nutr 140:259–263
Rogers PJ, Martin J, Smith C, Heatherley SV, Smit HJ (2003) Absence of reinforcing, mood and psychomotor performance effects of caffeine in habitual non-consumers of caffeine. Psychopharmacology (Berl) 167:54–62
Scholey AB, French SJ, Morris PJ, Kennedy DO, Milne AL, Haskell CF (2010) Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort. J Psychopharmacol 24:1505–1514
Schroeter H, Heiss C, Balzer J, Kleinbongard P, Keen CL, Hollenberg NK, Sies H, Kwik-Uribe C, Schmitz HH, Kelm M (2006) (−)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci U S A 103:1024–1029
Silva BA, Dias AC, Ferreres F, Malva JO, Oliveira CR (2004) Neuroprotective effect of H. perforatum extracts on beta-amyloid-induced neurotoxicity. Neurotox Res 6:119–130
Smit HJ, Rogers PJ (2000) Effects of low doses of caffeine on cognitive performance, mood and thirst in low and higher caffeine consumers. Psychopharmacology (Berl) 152:167–173
Smith A (2002) Effects of caffeine on human behavior. Food Chem Toxicol 40:1243–1255
Streit M, Wolwer W, Brinkmeyer J, Ihl R, Gaebel W (2000) Electrophysiological correlates of emotional and structural face processing in humans. Neurosci Lett 278:13–16
Van Boxtel MP, Schmitt JAJ (2004) Age-related changes in the effects of coffee on memory and cognitive performance. In: Nehlig A (ed) Coffee, Tea, Chocolate and the Brain (Nutrition, Brain, and Behavior: A Book Series). CRC Press, Boca Raton, pp 85–96
Van der Elst W, Van Boxtel MP, Van Breukelen GJ, Jolles J (2006) The Stroop color-word test: influence of age, sex, and education; and normative data for a large sample across the adult age range. Assessment 13:62–79
Wang Y, Ho CT (2009) Polyphenolic chemistry of tea and coffee: a century of progress. J Agric Food Chem 57:8109–8114
Warburton DM (1995) Effects of caffeine on cognition and mood without caffeine abstinence. Psychopharmacology (Berl) 119:66–70
Yeomans MR, Ripley T, Davies LH, Rusted JM, Rogers PJ (2002) Effects of caffeine on performance and mood depend on the level of caffeine abstinence. Psychopharmacology (Berl) 164:241–249
Yoshida Y, Hayakawa M, Niki E (2008) Evaluation of the antioxidant effects of coffee and its components using the biomarkers hydroxyoctadecadienoic acid and isoprostane. J Oleo Sci 57:691–697
Zang LY, Cosma G, Gardner H, Castranova V, Vallyathan V (2003) Effect of chlorogenic acid on hydroxyl radical. Mol Cell Biochem 247:205–210
The coffee products were provided free of charge by Nestle Research Center. This research was funded by Nestec Ltd (Nestle Research Center, Lausanne, Switzerland). BYS and JAJS are employees of Nestlé. Nestec, through employees BYS and JAJS, was involved in the concept of the study, the trial design, monitoring of data, interpretation and the writing, and approval of the report. The authors have full control of all primary data. The other authors declare no conflicts of interest.
Sources of support/disclosure statement
This research was funded by Nestec Ltd (Nestle Research Center, Lausanne, Switzerland). BYS and JAJS are employees of Nestlé. The other authors declare no conflicts of interest.
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Cropley, V., Croft, R., Silber, B. et al. Does coffee enriched with chlorogenic acids improve mood and cognition after acute administration in healthy elderly? A pilot study. Psychopharmacology 219, 737–749 (2012). https://doi.org/10.1007/s00213-011-2395-0
- Chlorogenic acid
- Event-related potentials