Psychopharmacology

, Volume 219, Issue 3, pp 737–749 | Cite as

Does coffee enriched with chlorogenic acids improve mood and cognition after acute administration in healthy elderly? A pilot study

  • Vanessa Cropley
  • Rodney Croft
  • Beata Silber
  • Chris Neale
  • Andrew Scholey
  • Con Stough
  • Jeroen Schmitt
Original Investigation

Abstract

Rationale

Caffeine exerts positive effects on cognitive and behavioral processes, especially in sub-optimal conditions when arousal is low. Apart from caffeine, coffee contains other compounds including the phenolic compounds ferulic acid, caffeic acid, and the chlorogenic acids, which have purported antioxidant properties. The chlorogenic acids are the most abundant family of compounds found in coffee, yet their effects on cognition and mood have not been investigated.

Objectives

This study aims to ascertain whether a coffee rich in chlorogenic acid modulates brain function.

Methods

The present pilot study examined the acute effects of decaffeinated coffee with regular chlorogenic acid content and decaffeinated coffee with high chlorogenic acid content on mood and cognitive processes, as measured by behavioral tasks and event-related potentials (ERPs). Performance and ERP responses to a battery of cognitive tasks were recorded at baseline and following the equivalent of three cups of coffee in a randomized, double-blind, crossover study of 39 healthy older participants.

Results

Compared with the decaffeinated coffee with regular chlorogenic acid and placebo, caffeinated coffee showed a robust positive effect on higher-level mood and attention processes. To a lesser extent, the decaffeinated coffee high in chlorogenic acid also improved some mood and behavioral measures, relative to regular decaffeinated coffee.

Conclusions

Our pilot results suggest that non-caffeine compounds in coffee such as the chlorogenic acids may be capable of exerting some acute behavioral effects, thus warranting further investigation.

Keywords

Coffee Chlorogenic acid Caffeine Cognition Mood Event-related potentials 

References

  1. Bond A, Lader M (1974) The use of analogue scales in rating subjective feelings. Br J Psychol 47:211–218CrossRefGoogle Scholar
  2. Bouayed J, Rammal H, Dicko A, Younos C, Soulimani R (2007) Chlorogenic acid, a polyphenol from Prunus domestica (Mirabelle), with coupled anxiolytic and antioxidant effects. J Neurol Sci 262:77–84PubMedCrossRefGoogle Scholar
  3. Chu YF, Brown PH, Lyle BJ, Chen Y, Black RM, Williams CE, Lin YC, Hsu CW, Cheng IH (2009) Roasted coffees high in lipophilic antioxidants and chlorogenic acid lactones are more neuroprotective than green coffees. J Agric Food Chem 57:9801–9808PubMedCrossRefGoogle Scholar
  4. Croft RJ, Barry RJ (2000) Removal of ocular artifact from the EEG: a review. Neurophysiol Clin 30:5–19PubMedCrossRefGoogle Scholar
  5. de Paulis T, Schmidt DE, Bruchey AK, Kirby MT, McDonald MP, Commers P, Lovinger DM, Martin PR (2002) Dicinnamoylquinides in roasted coffee inhibit the human adenosine transporter. Eur J Pharmacol 442:215–223PubMedCrossRefGoogle Scholar
  6. Eimer M, Holmes A (2007) Event-related brain potential correlates of emotional face processing. Neuropsychologia 45:15–31PubMedCrossRefGoogle Scholar
  7. Ekman P, Friesen W (1976) Pictures of facial affect. Consulting Psychologists Press, Consulting Psychologists PressGoogle Scholar
  8. Esposito E, Rotilio D, Di Matteo V, Di Giulio C, Cacchio M, Algeri S (2002) A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes. Neurobiol Aging 23:719–735PubMedCrossRefGoogle Scholar
  9. Evers EA, Tillie DE, van der Veen FM, Lieben CK, Jolles J, Deutz NE, Schmitt JA (2005) Effects of a novel method of acute tryptophan depletion on plasma tryptophan and cognitive performance in healthy volunteers. Psychopharmacology (Berl) 178:92–99CrossRefGoogle Scholar
  10. Faridi Z, Njike VY, Dutta S, Ali A, Katz DL (2008) Acute dark chocolate and cocoa ingestion and endothelial function: a randomized controlled crossover trial. Am J Clin Nutr 88:58–63PubMedGoogle Scholar
  11. Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198PubMedCrossRefGoogle Scholar
  12. Frewer LJ, Lader M (1991) The effects of caffeine on two computerized tests of attention and vigilance. Human Psychopharmacology 6:119–128CrossRefGoogle Scholar
  13. Gilbert DG, Sugai C, Zuo Y, Rabinovich NE, McClernon FJ, Froeliger B (2007) Brain indices of nicotine's effects on attentional bias to smoking and emotional pictures and to task-relevant targets. Nicotine Tob Res 9:351–363PubMedCrossRefGoogle Scholar
  14. Gomez-Ruiz JA, Leake DS, Ames JM (2007) In vitro antioxidant activity of coffee compounds and their metabolites. Journal of Agricultural and Food Chemistry 55:6962–6969PubMedCrossRefGoogle Scholar
  15. Hammes J (1973) The Stroop Color–Word Test: Manual. The Netherlands, Swets & ZeitlingerGoogle Scholar
  16. Han J, Miyamae Y, Shigemori H, Isoda H (2010) Neuroprotective effect of 3,5-di-O-caffeoylquinic acid on SH-SY5Y cells and senescence-accelerated-prone mice 8 through the up-regulation of phosphoglycerate kinase-1. Neuroscience 169:1039–1045PubMedCrossRefGoogle Scholar
  17. Haskell CF, Kennedy DO, Wesnes KA, Scholey AB (2005) Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine. Psychopharmacology (Berl) 179:813–825CrossRefGoogle Scholar
  18. Haskell CF, Kennedy DO, Milne AL, Wesnes KA, Scholey AB (2008) The effects of l-theanine, caffeine and their combination on cognition and mood. Biol Psychol 77:113–122PubMedCrossRefGoogle Scholar
  19. Huang YX, Luo YJ (2006) Temporal course of emotional negativity bias: an ERP study. Neurosci Lett 398:91–96PubMedCrossRefGoogle Scholar
  20. Humphreys MS, Revelle W (1984) Personality, motivation, and performance: a theory of the relationship between individual differences and information processing. Psychol Rev 91:153–184PubMedCrossRefGoogle Scholar
  21. Hur JY, Soh Y, Kim BH, Suk K, Sohn NW, Kim HC, Kwon HC, Lee KR, Kim SY (2001) Neuroprotective and neurotrophic effects of quinic acids from Aster scaber in PC12 cells. Biol Pharm Bull 24:921–924PubMedCrossRefGoogle Scholar
  22. Jones GM, Sahakian BJ, Levy R, Warburton DM, Gray JA (1992) Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in Alzheimer's disease. Psychopharmacology (Berl) 108:485–494CrossRefGoogle Scholar
  23. Kennedy DO, Scholey AB (2004) A glucose-caffeine 'energy drink' ameliorates subjective and performance deficits during prolonged cognitive demand. Appetite 42:331–333PubMedCrossRefGoogle Scholar
  24. Kennedy DO, Wightman EL, Reay JL, Lietz G, Okello EJ, Wilde A, Haskell CF (2010) Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. Am J Clin Nutr 91:1590–1597PubMedCrossRefGoogle Scholar
  25. Kerestes R, Labuschagne I, Croft RJ, O'Neill BV, Bhagwagar Z, Phan KL, Nathan PJ (2009) Evidence for modulation of facial emotional processing bias during emotional expression decoding by serotonergic and noradrenergic antidepressants: an event-related potential (ERP) study. Psychopharmacology (Berl) 202:621–634CrossRefGoogle Scholar
  26. Kim SS, Park RY, Jeon HJ, Kwon YS, Chun W (2005) Neuroprotective effects of 3,5-dicaffeoylquinic acid on hydrogen peroxide-induced cell death in SH-SY5Y cells. Phytother Res 19:243–245PubMedCrossRefGoogle Scholar
  27. Koelega HS (1993) Stimulant drugs and vigilance performance: a review. Psychopharmacology (Berl) 111:1–16CrossRefGoogle Scholar
  28. Kono Y, Kashine S, Yoneyama T, Sakamoto Y, Matsui Y, Shibata H (1998) Iron chelation by chlorogenic acid as a natural antioxidant. Biosci Biotechnol Biochem 62:22–27PubMedCrossRefGoogle Scholar
  29. Kwon SH, Lee HK, Kim JA, Hong SI, Kim HC, Jo TH, Park YI, Lee CK, Kim YB, Lee SY, Jang CG (2010) Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice. Eur J Pharmacol 649:210–217PubMedCrossRefGoogle Scholar
  30. Labuschagne I, Croft R, Phan K, Nathan P (2010) Augmenting serotonin neurotransmission with citalopram modulates emotional expression decoding but not structural encoding of moderate intensity sad facial emotional stimuli: an event-related potential (ERP) investigation. J Psychopharmacol 24:1153–1164PubMedCrossRefGoogle Scholar
  31. Lapchak PA (2007) The phenylpropanoid micronutrient chlorogenic acid improves clinical rating scores in rabbits following multiple infarct ischemic strokes: synergism with tissue plasminogen activator. Exp Neurol 205:407–413PubMedCrossRefGoogle Scholar
  32. Leung S, Croft RJ, O'Neill BV, Nathan PJ (2008) Acute high-dose glycine attenuates mismatch negativity (MMN) in healthy human controls. Psychopharmacology (Berl) 196:451–460CrossRefGoogle Scholar
  33. Näätänen R (1992) Attention and brain function. Lawrence Erlbaum Associates, Lawrence Erlbaum AssociatesGoogle Scholar
  34. Nardini M, Cirillo E, Natella F, Scaccini C (2002) Absorption of phenolic acids in humans after coffee consumption. J Agric Food Chem 50:5735–5741PubMedCrossRefGoogle Scholar
  35. Natella F, Nardini M, Giannetti I, Dattilo C, Scaccini C (2002) Coffee drinking influences plasma antioxidant capacity in humans. J Agric Food Chem 50:6211–6216PubMedCrossRefGoogle Scholar
  36. Nathan PJ, Tanner S, Lloyd J, Harrison B, Curran L, Oliver C, Stough C (2004) Effects of a combined extract of Ginkgo biloba and Bacopa monniera on cognitive function in healthy humans. Hum Psychopharmacol 19:91–96PubMedCrossRefGoogle Scholar
  37. Olthof MR, Hollman PC, Katan MB (2001) Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr 131:66–71PubMedGoogle Scholar
  38. Pellegrini N, Serafini M, Colombi B, Del Rio D, Salvatore S, Bianchi M, Brighenti F (2003) Total antioxidant capacity of plant foods, beverages and oils consumed in Italy assessed by three different in vitro assays. J Nutr 133:2812–2819PubMedGoogle Scholar
  39. Polich J (2007) Updating P300: an integrative theory of P3a and P3b. Clin Neurophysiol 118:2128–2148PubMedCrossRefGoogle Scholar
  40. Ramassamy C (2006) Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets. European Journal of Pharmacology 545:51–64PubMedCrossRefGoogle Scholar
  41. Rees K, Allen D, Lader M (1999) The influences of age and caffeine on psychomotor and cognitive function. Psychopharmacology (Berl) 145:181–188CrossRefGoogle Scholar
  42. Renouf M, Guy PA, Marmet C, Fraering AL, Longet K, Moulin J, Enslen M, Barron D, Dionisi F, Cavin C, Williamson G, Steiling H (2010a) Measurement of caffeic and ferulic acid equivalents in plasma after coffee consumption: small intestine and colon are key sites for coffee metabolism. Mol Nutr Food Res 54:760–766PubMedCrossRefGoogle Scholar
  43. Renouf M, Marmet C, Guy P, Fraering AL, Longet K, Moulin J, Enslen M, Barron D, Cavin C, Dionisi F, Rezzi S, Kochhar S, Steiling H, Williamson G (2010b) Nondairy creamer, but not milk, delays the appearance of coffee phenolic acid equivalents in human plasma. J Nutr 140:259–263PubMedCrossRefGoogle Scholar
  44. Rogers PJ, Martin J, Smith C, Heatherley SV, Smit HJ (2003) Absence of reinforcing, mood and psychomotor performance effects of caffeine in habitual non-consumers of caffeine. Psychopharmacology (Berl) 167:54–62Google Scholar
  45. Scholey AB, French SJ, Morris PJ, Kennedy DO, Milne AL, Haskell CF (2010) Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort. J Psychopharmacol 24:1505–1514PubMedCrossRefGoogle Scholar
  46. Schroeter H, Heiss C, Balzer J, Kleinbongard P, Keen CL, Hollenberg NK, Sies H, Kwik-Uribe C, Schmitz HH, Kelm M (2006) (−)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci U S A 103:1024–1029PubMedCrossRefGoogle Scholar
  47. Silva BA, Dias AC, Ferreres F, Malva JO, Oliveira CR (2004) Neuroprotective effect of H. perforatum extracts on beta-amyloid-induced neurotoxicity. Neurotox Res 6:119–130PubMedCrossRefGoogle Scholar
  48. Smit HJ, Rogers PJ (2000) Effects of low doses of caffeine on cognitive performance, mood and thirst in low and higher caffeine consumers. Psychopharmacology (Berl) 152:167–173CrossRefGoogle Scholar
  49. Smith A (2002) Effects of caffeine on human behavior. Food Chem Toxicol 40:1243–1255PubMedCrossRefGoogle Scholar
  50. Streit M, Wolwer W, Brinkmeyer J, Ihl R, Gaebel W (2000) Electrophysiological correlates of emotional and structural face processing in humans. Neurosci Lett 278:13–16PubMedCrossRefGoogle Scholar
  51. Van Boxtel MP, Schmitt JAJ (2004) Age-related changes in the effects of coffee on memory and cognitive performance. In: Nehlig A (ed) Coffee, Tea, Chocolate and the Brain (Nutrition, Brain, and Behavior: A Book Series). CRC Press, Boca Raton, pp 85–96Google Scholar
  52. Van der Elst W, Van Boxtel MP, Van Breukelen GJ, Jolles J (2006) The Stroop color-word test: influence of age, sex, and education; and normative data for a large sample across the adult age range. Assessment 13:62–79PubMedCrossRefGoogle Scholar
  53. Wang Y, Ho CT (2009) Polyphenolic chemistry of tea and coffee: a century of progress. J Agric Food Chem 57:8109–8114PubMedCrossRefGoogle Scholar
  54. Warburton DM (1995) Effects of caffeine on cognition and mood without caffeine abstinence. Psychopharmacology (Berl) 119:66–70CrossRefGoogle Scholar
  55. Yeomans MR, Ripley T, Davies LH, Rusted JM, Rogers PJ (2002) Effects of caffeine on performance and mood depend on the level of caffeine abstinence. Psychopharmacology (Berl) 164:241–249CrossRefGoogle Scholar
  56. Yoshida Y, Hayakawa M, Niki E (2008) Evaluation of the antioxidant effects of coffee and its components using the biomarkers hydroxyoctadecadienoic acid and isoprostane. J Oleo Sci 57:691–697PubMedCrossRefGoogle Scholar
  57. Zang LY, Cosma G, Gardner H, Castranova V, Vallyathan V (2003) Effect of chlorogenic acid on hydroxyl radical. Mol Cell Biochem 247:205–210PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Vanessa Cropley
    • 1
    • 4
  • Rodney Croft
    • 2
  • Beata Silber
    • 3
  • Chris Neale
    • 1
    • 4
  • Andrew Scholey
    • 1
    • 4
  • Con Stough
    • 1
    • 4
  • Jeroen Schmitt
    • 3
  1. 1.Brain Sciences InstituteSwinburne University of TechnologyMelbourneAustralia
  2. 2.School of PsychologyUniversity of WollongongWollongongAustralia
  3. 3.Nestle Research CenterLausanneSwitzerland
  4. 4.Centre for Human PsychopharmacologySwinburne University of TechnologyMelbourneAustralia

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