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The role of early life stress as a predictor for alcohol and drug dependence

Abstract

Rationale

Genetic and environmental influences on the development of alcohol and drug dependence are equally important. Exposure to early life stress, that is unfortunately common in the general population, has been shown to predict a wide range of psychopathology, including addiction.

Objective

This review will look at the characteristics of early life stress that may be specific predictors for adolescent and adult alcohol and drug dependence and will focus on studies in humans, non-human primates and rodents.

Results

Experiencing maltreatment and cumulative stressful life events prior to puberty and particularly in the first few years of life is associated with early onset of problem drinking in adolescence and alcohol and drug dependence in early adulthood. Early life stress can result in permanent neurohormonal and hypothalamic-pituitary-adrenal axis changes, morphological changes in the brain, and gene expression changes in the mesolimbic dopamine reward pathway, all of which are implicated in the development of addiction. However, a large proportion of children who have experienced even severe early life stress do not develop psychopathology indicating that mediating factors such as gene–environment interactions and family and peer relationships are important for resilience.

Conclusions

There appears to be a direct pathway from chronic stress exposure in pre-pubertal children via adolescent problem drinking to alcohol and drug dependence in early adulthood. However, this route can be moderated by genetic and environmental factors. The role that gene–environment interactions play in the risk-resilience balance is being increasingly recognized.

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References

  • Afifi T, Enns M, Cox B, Asmundson G, Stein M, Sareen J (2008) Population attributable fractions of psychiatric disorders and suicide ideation and attempts associated with adverse childhood experiences. Am J Pub Health 98:946–952

    Google Scholar 

  • Agartz I, Momenan R, Rawlings RR, Kerich MJ, Hommer DW (1999) Hippocampal volume in patients with alcohol dependence. Arch Gen Psychiatry 56:356–363

    PubMed  CAS  Google Scholar 

  • Ambroggi F, Turiault M, Milet A, Deroche-Gamonet V, Parnaudeau S, Balado E, Barik J, van der Veen R, Maroteaux G, Lemberger T, Schütz G, Lazar M, Marinelli M, Piazza PV, Tronche F (2009) Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking. Nat Neurosci 12:247–249

    PubMed  CAS  Google Scholar 

  • American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Washington DC

  • Anda RF, Whitfield CL, Felitti VJ, Chapman D, Edwards VJ, Dube SR, Williamson DF (2002) Adverse childhood experiences, alcoholic parents, and later risk of alcoholism and depression. Psychiatr Serv 53:1001–1009

    PubMed  Google Scholar 

  • Andersen SL, Tomada A, Vincow ES, Valente E, Polcari A, Teicher MH (2008) Preliminary evidence for sensitive periods in the effect of childhood sexual abuse on regional brain development. J Neuropsychiatry Clin Neurosci 20:292–301

    PubMed  Google Scholar 

  • Arias I (2004) The legacy of child maltreatment: long-term health consequences for women. J Womens Health (Larchmt) 13:468–473

    Google Scholar 

  • Armeli S, Conner TS, Covault J, Tennen H, Kranzler HR (2008) A serotonin transporter gene polymorphism (5-HTTLPR), drinking-to-cope motivation, and negative life events among college students. J Stud Alcohol Drugs 69:814–823

    PubMed  Google Scholar 

  • Arnow BA (2004) Relationships between childhood maltreatment, adult health and psychiatric outcomes, and medical utilization. J Clin Psychiatry 65(Suppl 12):10–15

    PubMed  Google Scholar 

  • Barr CS, Newman TK, Lindell S, Shannon C, Champoux M, Lesch KP, Suomi SJ, Goldman D, Higley JD (2004) Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates. Arch Gen Psychiatry 61:1146–1152

    PubMed  CAS  Google Scholar 

  • Barr CS, Dvoskin RL, Gupte M, Sommer W, Sun H, Schwandt ML, Lindell SG, Kasckow JW, Suomi SJ, Goldman D, Higley JD, Heilig M (2009) Functional CRH variation increases stress-induced alcohol consumption in primates. Proc Natl Acad Sci U S A 106:14593–14598

    PubMed  CAS  Google Scholar 

  • Barrot M, Olivier JD, Perrotti LI, DiLeone RJ, Berton O, Eisch AJ, Impey S, Storm DR, Neve RL, Yin JC, Zachario V, Nestler EJ (2002) CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc Natl Acad Sci USA 99:1143–11440

    Google Scholar 

  • Bernstein DP, Stein JA, Newcomb MD, Walker E, Pogge D, Ahluvalia T, Stokes J, Handelsman L, Medrano M, Desmond D, Zule W (2003) Development and validation of a brief screening version of the Childhood Trauma Questionnaire. Child Abuse Negl 27:169–190

    PubMed  Google Scholar 

  • Binder EB, Bradley RG, Liu W, Epstein MP, Deveau TC, Mercer KB, Tang Y, Gillespie CF, Heim CM, Nemeroff CB, Schwartz AC, Cubells JF, Ressler KJ (2008) Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA 299:1291–1305

    PubMed  CAS  Google Scholar 

  • Binder EB, Owens MJ, Liu W, Deveau TC, Rush AJ, Trivedi MH, Fava M, Bradley B, Ressler KJ, Nemeroff CB (2010) Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response. Arch Gen Psychiatry 67:369–379

    PubMed  CAS  Google Scholar 

  • Blomeyer D, Treutlein J, Esser G, Schmidt MH, Schumann G, Laucht M (2008) Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use. Biol Psychiatry 63:146–151

    PubMed  CAS  Google Scholar 

  • Bonomo YA, Bowes G, Coffey C, Carlin JB, Patton GC (2004) Teenage drinking and the onset of alcohol dependence: a cohort study over seven years. Addiction 99:1520–1528

    PubMed  Google Scholar 

  • Bradley RG, Binder EB, Epstein MP, Tang Y, Nair HP, Liu W, Gillespie CF, Berg T, Evces M, Newport DJ, Stowe ZN, Heim CM, Nemeroff CB, Schwartz A, Cubells JF, Ressler KJ (2008) Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene. Arch Gen Psychiatry 65:190–200

    PubMed  CAS  Google Scholar 

  • Brake WG, Zhang TY, Diorio J, Meaney MJ, Gratton A (2004) Influence of early postnatal rearing conditions on mesocorticolimbic dopamine and behavioural responses to psychostimulants and stressors in adult rats. Eur J Neurosci 19:1863–1874

    PubMed  Google Scholar 

  • Bremner JD, Bolus R, Mayer EA (2007) Psychometric properties of the Early Trauma Inventory-Self Report. J Nerv Ment Dis 195:211–218

    PubMed  Google Scholar 

  • Briere J, Elliott DM (2003) Prevalence and psychological sequelae of self-reported childhood physical and sexual abuse in a general population sample of men and women. Child Abuse Negl 27:1205–1222

    PubMed  Google Scholar 

  • Bulik CM, Prescott CA, Kendler KS (2001) Features of childhood sexual abuse and the development of psychiatric and substance use disorders. Br J Psychiatry 179:444–449

    PubMed  CAS  Google Scholar 

  • Caldji C, Diorio J, Meaney MJ (2000) Variations in maternal care in infancy regulate the development of stress reactivity. Biol Psychiatry 48:1164–1174

    PubMed  CAS  Google Scholar 

  • Caldji C, Diorio J, Meaney MJ (2003) Variations in maternal care alter GABA(A) receptor subunit expression in brain regions associated with fear. Neuropsychopharmacology 28:1950–1959

    PubMed  CAS  Google Scholar 

  • Cardenas VA, Studholme C, Gazdzinski S, Durazzo TC, Meyerhoff DJ (2007) Deformation-based morphometry of brain changes in alcohol dependence and abstinence. Neuroimage 34:879–887

    PubMed  Google Scholar 

  • Carpenter LL, Carvalho JP, Tyrka AR, Wier LM, Mello AF, Mello MF, Anderson GM, Wilkinson CW, Price LH (2007) Decreased adrenocorticotropic hormone and cortisol responses to stress in healthy adults reporting significant childhood maltreatment. Biol Psychiatry 62:1080–1087

    PubMed  CAS  Google Scholar 

  • Carpenter LL, Tyrka AR, Ross NS, Khoury L, Anderson GM, Price LH (2009) Effect of childhood emotional abuse and age on cortisol responsivity in adulthood. Biol Psychiatry 66:69–75

    PubMed  CAS  Google Scholar 

  • Caspi A, Moffitt TE, Newman DL, Silva PA (1996) Behavioral observations at age 3 years predict adult psychiatric disorders. Longitudinal evidence from a birth cohort. Arch Gen Psychiatry 53:1033–1039

    PubMed  CAS  Google Scholar 

  • Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R (2002) Role of genotype in the cycle of violence in maltreated children. Science 297:851–854

    PubMed  CAS  Google Scholar 

  • Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301:386–389

    PubMed  CAS  Google Scholar 

  • Caspi A, Hariri AR, Holmes A, Uher R, Moffitt TE (2010) Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry (in press)

  • Chanraud S, Martelli C, Delain F, Kostogianni N, Douaud G, Aubin HJ, Reynaud M, Martinot JL (2007) Brain morphometry and cognitive performance in detoxified alcohol-dependents with preserved psychosocial functioning. Neuropsychopharmacology 32:429–438

    PubMed  Google Scholar 

  • Choi J, Jeong B, Rohan ML, Polcari AM, Teicher MH (2009) Preliminary evidence for white matter tract abnormalities in young adults exposed to parental verbal abuse. Biol Psychiatry 65:227–234

    PubMed  Google Scholar 

  • Compton WM, Thomas YF, Stinson FS, Grant BF (2007) Prevalence, correlates, disability, and comorbidity of DSM-IV drug abuse and dependence in the United States: results from the national epidemiologic survey on alcohol and related conditions. Arch Gen Psychiatry 64:566–576

    PubMed  Google Scholar 

  • Corominas M, Roncero C, Casas M (2010) Corticotropin releasing factor and neuroplasticity in cocaine addiction. Life Sci 86:1–9

    PubMed  CAS  Google Scholar 

  • Covault J, Tennen H, Armeli S, Conner TS, Herman AI, Cillessen AH, Kranzler HR (2007) Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use. Biol Psychiatry 61:609–616

    PubMed  CAS  Google Scholar 

  • Dai X, Thavundayil J, Gianoulakis C (2005) Differences in the peripheral levels of beta-endorphin in response to alcohol and stress as a function of alcohol dependence and family history of alcoholism. Alcohol Clin Exp Res 29:1965–1975

    PubMed  CAS  Google Scholar 

  • Dai X, Thavundayil J, Santella S, Gianoulakis C (2007) Response of the HPA-axis to alcohol and stress as a function of alcohol dependence and family history of alcoholism. Psychoneuroendocrinology 32:293–305

    PubMed  CAS  Google Scholar 

  • De Bellis MD (2002) Developmental traumatology: a contributory mechanism for alcohol and substance use disorders. Psychoneuroendocrinology 27:155–170

    PubMed  Google Scholar 

  • De Bellis MD, Clark DB, Beers SR, Soloff PH, Boring AM, Hall J, Kersh A, Keshavan MS (2000) Hippocampal volume in adolescent-onset alcohol use disorders. Am J Psychiatry 157:737–744

    PubMed  Google Scholar 

  • De Bellis MD, Van Voorhees E, Hooper SR, Gibler N, Nelson L, Hege SG, Payne ME, MacFall J (2008) Diffusion tensor measures of the corpus callosum in adolescents with adolescent onset alcohol use disorders. Alcohol Clin Exp Res 32:395–404

    PubMed  Google Scholar 

  • Deroche-Gamonet V, Sillaber I, Aouizerate B, Izawa R, Jaber M, Ghozland S, Kellendonk C, Le Moal M, Spanagel R, Schütz G, Tronche F, Piazza PV (2003) The glucocorticoid receptor as a potential target to reduce cocaine abuse. J Neurosci 23:4785–4790

    PubMed  CAS  Google Scholar 

  • Dick DM, Pagan JL, Viken R, Purcell S, Kaprio J, Pulkkinen L, Rose RJ (2007) Changing environmental influences on substance use across development. Twin Res Hum Genet 10:315–326

    PubMed  Google Scholar 

  • Dick DM, Latendresse SJ, Lansford JE, Budde JP, Goate A, Dodge KA, Pettit GS, Bates JE I (2009) Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring. Arch Gen Psychiatry 66:649–657

    PubMed  CAS  Google Scholar 

  • Dillon DG, Holmes AJ, Birk JL, Brooks N, Lyons-Ruth K, Pizzagalli DA (2009) Childhood adversity is associated with left basal ganglia dysfunction during reward anticipation in adulthood. Biol Psychiatry 66:206–213

    PubMed  Google Scholar 

  • Dodge KA, Bates JE, Pettit GS (1990) Mechanisms in the cycle of violence. Science 250:1678–1683

    PubMed  CAS  Google Scholar 

  • Dong M, Anda RF, Felitti VJ, Dube SR, Williamson DF, Thompson TJ, Loo CM, Giles WH (2004) The interrelatedness of multiple forms of childhood abuse, neglect, and household dysfunction. Child Abuse Negl 28:771–784

    PubMed  Google Scholar 

  • Dube SR, Anda RF, Whitfield CL, Brown DW, Felitti VJ, Dong M, Giles WH (2005) Long-term consequences of childhood sexual abuse by gender of victim. Am J Prev Med 28:430–438

    PubMed  Google Scholar 

  • Dube SR, Miller JW, Brown DW, Giles WH, Felitti VJ, Dong M, Anda RF (2006) Adverse childhood experiences and the association with ever using alcohol and initiating alcohol use during adolescence. J Adolesc Health 38:444.e1–444.10

    Google Scholar 

  • Ducci F, Enoch M-A, Hodgkinson C, Xu K, Catena M, Robin RW, Goldman D (2008) Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women. Mol Psychiatry 13:334–347

    PubMed  CAS  Google Scholar 

  • Ducci F, Roy A, Shen PH, Yuan Q, Yuan NP, Hodgkinson CA, Goldman LR, Goldman D (2009) Association of substance use disorders with childhood trauma but not African genetic heritage in an African American cohort. Am J Psychiatry 166:1031–1040

    PubMed  Google Scholar 

  • DuMont KA, Widom CS, Czaja SJ (2007) Predictors of resilience in abused and neglected children grown-up: the role of individual and neighborhood characteristics. Child Abuse Negl 31:255–274

    PubMed  Google Scholar 

  • Eaves LJ, Prom EC, Silberg JL (2010) The mediating effect of parental neglect on adolescent and young adult anti-sociality: a longitudinal study of twins and their parents. Behav Genet (in press)

  • Edenberg HJ (2007) The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res Health 30:5–13, Review

    PubMed  Google Scholar 

  • Englund MM, Egeland B, Oliva EM, Collins WA (2008) Childhood and adolescent predictors of heavy drinking and alcohol use disorders in early adulthood: a longitudinal developmental analysis. Addiction 103(Suppl 1):23–35

    PubMed  Google Scholar 

  • Enoch M-A (2006) Genetic and environmental influences on the development of alcoholism: resilience vs. risk. Ann N Y Acad Sci 1094:193–201

    PubMed  Google Scholar 

  • Enoch MA (2008) The role of GABA(A) receptors in the development of alcoholism. Pharmacol Biochem Behav 90:95–104

    PubMed  CAS  Google Scholar 

  • Enoch M-A, Steer CD, Newman TK, Gibson N, Goldman D (2010a) The impact of early life stress, MAOA, and gene–environment interaction on behavioral disinhibition in pre-pubertal children. Genes Brain Behav 9:65–74

    PubMed  Google Scholar 

  • Enoch M-A, Hodgkinson CA, Yuan Q, Shen P-H, Goldman D, Roy A (2010b) The influence of GABRA2, childhood trauma and their interaction on alcohol, heroin and cocaine dependence. Biol Psychiatry 67:20–27

    PubMed  CAS  Google Scholar 

  • Fergusson DM, Woodward LJ, Horwood LJ (1999) Childhood peer relationship problems and young people's involvement with deviant peers in adolescence. J Abnorm Child Psychol 27:357–369

    PubMed  CAS  Google Scholar 

  • Fergusson DM, Horwood LJ, Woodward LJ (2000) The stability of child abuse reports: a longitudinal study of the reporting behaviour of young adults. Psychol Med 30:529–544

    PubMed  CAS  Google Scholar 

  • Fergusson DM, Boden JM, Horwood LJ (2008) The developmental antecedents of illicit drug use: evidence from a 25-year longitudinal study. Drug Alcohol Depend 96:165–167

    PubMed  Google Scholar 

  • Foley DL, Eaves LJ, Wormley B, Silberg JL, Maes HH, Kuhn J, Riley B (2004) Childhood adversity, monoamine oxidase A genotype, and risk for conduct disorder. Arch Gen Psychiatry 61:738–744

    PubMed  CAS  Google Scholar 

  • Gerra G, Zaimovic A, Castaldini L, Garofano L, Manfredini M, Somaini L, Leonardi C, Gerra ML, Donnini C (2010) Relevance of perceived childhood neglect, 5-HTT gene variants and hypothalamus-pituitary-adrenal axis dysregulation to substance abuse susceptibility. Am J Med Genet B Neuropsychiatr Genet 153B:715–722

    PubMed  CAS  Google Scholar 

  • Glatz K, Mossner R, Heils A, Lesch KP (2003) Glucocorticoid-regulated human serotonin transporter (5-HTT) expression is modulated by the 5-HTT gene-promoter linked polymorphic region. J Neurochem 86:1072–1078

    PubMed  CAS  Google Scholar 

  • Goldman J, Salus MK, Wolcott D, Kennedy KY (2003) A coordinated response to child abuse and neglect: The Foundation for practice. Office on Child Abuse and Neglect (HHS), Washington, DC. (Available online at the Child Welfare Information Gateway).

  • Goldman D, Oroszi G, Ducci F (2005) The genetics of addictions: uncovering the genes. Nat Rev Genet 6:521–532

    PubMed  CAS  Google Scholar 

  • Goodman-Brown TB, Edelstein RS, Goodman GS, Jones DP, Gordon DS (2003) Why children tell: a model of children's disclosure of sexual abuse. Child Abuse Negl 27:525–540

    PubMed  Google Scholar 

  • Grant BF, Stinson FS, Harford TC (2001) Age at onset of alcohol use and DSM-IV alcohol abuse and dependence: a 12-year follow-up. J Subst Abuse 13:493–504

    PubMed  CAS  Google Scholar 

  • Grayson CE, Nolen-Hoeksema S (2005) Motives to drink as mediators between childhood sexual assault and alcohol problems in adult women. J Trauma Stress 18:137–145

    PubMed  Google Scholar 

  • Green JG, McLaughlin KA, Berglund PA, Gruber MJ, Sampson NA, Zaslavsky AM, Kessler RC (2010) Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: associations with first onset of DSM-IV disorders. Arch Gen Psychiatry 67:113–123

    PubMed  Google Scholar 

  • Guerri C, Pascual M (2010) Mechanisms involved in the neurotoxic, cognitive, and neurobehavioral effects of alcohol consumption during adolescence. Alcohol 44:15–26

    PubMed  CAS  Google Scholar 

  • Gunnar MR, Donzella B (2002) Social regulation of the cortisol levels in early human development. Psychoneuroendocrinology 27:199–220

    PubMed  CAS  Google Scholar 

  • Haberstick BC, Lessem JM, Hopfer CJ, Smolen A, Ehringer MA, Timberlake D, Hewitt JK (2005) Monoamine oxidase A (MAOA) and antisocial behaviors in the presence of childhood and adolescent maltreatment. Am J Med Genet B Neuropsychiatr Genet 135:59–64

    Google Scholar 

  • Hansson AC, Cippitelli A, Sommer WH, Fedeli A, Björk K, Soverchia L, Terasmaa A, Massi M, Heilig M, Ciccocioppo R (2006) Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress. Proc Natl Acad Sci U S A 103:15236–15241

    PubMed  CAS  Google Scholar 

  • Harford TC, Grant BF, Yi HY, Chen CM (2005) Patterns of DSM-IV alcohol abuse and dependence criteria among adolescents and adults: results from the 2001 National Household Survey on Drug Abuse. Alcohol Clin Exp Res 29:810–828

    PubMed  Google Scholar 

  • Hariri AR, Holmes A (2006) Genetics of emotional regulation: the role of the serotonin transporter in neural function. Trends Cogn Sci 10:182–191

    PubMed  Google Scholar 

  • Hariri AR, Drabant EM, Munoz KE, Kolachana BS, Mattay VS, Egan MF, Weinberger DR (2005) A susceptibility gene for affective disorders and the response of the human amygdala. Arch Gen Psychiatry 62:146–152

    PubMed  CAS  Google Scholar 

  • Hasin DS, Stinson FS, Ogburn E, Grant BF (2007) Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch Gen Psychiatry 64:830–842

    PubMed  Google Scholar 

  • Heath AC, Nelson EC (2002) Effects of the interaction between genotype and environment. Research into the genetic epidemiology of alcohol dependence. Alcohol Res Health 26:193–201

    PubMed  Google Scholar 

  • Heffernan K, Cloitre M, Tardiff K, Marzuk PM, Portera L, Leon AC (2000) Childhood trauma as a correlate of lifetime opiate use in psychiatric patients. Addict Behav 25:797–803

    PubMed  CAS  Google Scholar 

  • Heim C, Bradley B, Mletzko TC, Deveau TC, Musselman DL, Nemeroff CB, Ressler KJ, Binder EB (2009) Effect of childhood trauma on adult depression and neuroendocrine function: sex-specific moderation by CRH receptor 1 gene. Front Behav Neurosci 3:41

    PubMed  Google Scholar 

  • Hicks BM, South SC, Dirago AC, Iacono WG, McGue M (2009) Environmental adversity and increasing genetic risk for externalizing disorders. Arch Gen Psychiatry 66:640–648

    PubMed  Google Scholar 

  • Higley JD, Hasert MF, Suomi SJ, Linnoila M (1991) Nonhuman primate model of alcohol abuse: effects of early experience, personality, and stress on alcohol consumption. Proc Natl Acad Sci U S A 88:7261–7265

    PubMed  CAS  Google Scholar 

  • Holmes W, Slap G (1998) Sexual abuse of boys: definition, prevalence, correlates, sequelae, and management. JAMA 280:1855–1862

    PubMed  CAS  Google Scholar 

  • Hsu FC, Zhang GJ, Raol YS, Valentino RJ, Coulter DA, Brooks-Kayal AR (2003) Repeated neonatal handling with maternal separation permanently alters hippocampal GABAA receptors and behavioral stress responses. Proc Natl Acad Sci USA 100:12213–12218

    PubMed  CAS  Google Scholar 

  • Huot RL, Thrivikraman KV, Meaney MJ, Plotsky PM (2001) Development of adult ethanol preference and anxiety as a consequence of neonatal maternal separation in Long Evans rats and reversal with antidepressant treatment. Psychopharmacology (Berl) 158:366–373

    CAS  Google Scholar 

  • Hyman SM, Sinha R (2009) Stress-related factors in cannabis use and misuse: implications for prevention and treatment. J Subst Abuse Treat 36:400–413

    PubMed  Google Scholar 

  • Hyman SM, Garcia M, Sinha R (2006) Gender specific associations between types of childhood maltreatment and the onset, escalation and severity of substance use in cocaine dependent adults. Am J Drug Alcohol Abuse 32:655–664

    PubMed  Google Scholar 

  • Hyman SM, Paliwal P, Chaplin TM, Mazure CM, Rounsaville BJ, Sinha R (2008) Severity of childhood trauma is predictive of cocaine relapse outcomes in women but not men. Drug Alcohol Depend 92:208–216

    PubMed  CAS  Google Scholar 

  • Jaffee SR, Caspi A, Moffitt TE, Dodge KA, Rutter M, Taylor A, Tully LA (2005) Nature X nurture: genetic vulnerabilities interact with physical maltreatment to promote conduct problems. Dev Psychopathol 17:67–84

    PubMed  Google Scholar 

  • Jaffee SR, Caspi A, Moffitt TE, Polo-Tomás M, Taylor A (2007) Individual, family, and neighborhood factors distinguish resilient from non-resilient maltreated children: a cumulative stressors model. Child Abuse Negl 31:231–253

    PubMed  Google Scholar 

  • Jasinski JL, Williams LM, Siegel J (2000) Childhood physical and sexual abuse as risk factors for heavy drinking among African-American women: a prospective study. Child Abuse Negl 24:1061–1071

    PubMed  CAS  Google Scholar 

  • Kalivas PW (1993) Neurotransmitter regulation of dopamine neurons in the ventral tegmental area. Brain Res Brain Res Rev 18:75–113

    PubMed  CAS  Google Scholar 

  • Kaplow JB, Widom CS (2007) Age of onset of child maltreatment predicts long-term mental health outcomes. J Abnorm Psychol 116:176–187

    PubMed  Google Scholar 

  • Kaufman J, Yang BZ, Douglas-Palumberi H, Crouse-Artus M, Lipschitz D, Krystal JH, Gelernter J (2007) Genetic and environmental predictors of early alcohol use. Biol Psychiatry 61:1228–1234

    PubMed  CAS  Google Scholar 

  • Keiley MK, Howe TR, Dodge KA, Bates JE, Petti GS (2001) The timing of child physical maltreatment: a cross-domain growth analysis of impact on adolescent externalizing and internalizing problems. Dev Psychopathol 13:891–912

    PubMed  CAS  Google Scholar 

  • Kendler KS, Bulik CM, Silberg J, Hettema JM, Myers J, Prescott CA (2000) Childhood sexual abuse and adult psychiatric and substance use disorders in women: an epidemiological and cotwin control analysis. Arch Gen Psychiatry 57:953–959

    PubMed  CAS  Google Scholar 

  • Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62:593–602

    PubMed  Google Scholar 

  • Koob GF (2003) Alcoholism: allostasis and beyond. Alcohol Clin Exp Res 27:232–243

    PubMed  CAS  Google Scholar 

  • Koob GF (2009) New dimensions in human laboratory models of addiction. Addict Biol 14:1–8

    PubMed  Google Scholar 

  • Kim-Cohen J, Caspi A, Taylor A, Williams B, Newcombe R, Craig IW, Moffitt TE (2006) MAOA, maltreatment, and gene–environment interaction predicting children's mental health: new evidence and a meta-analysis. Mol Psychiatry 11:903–913

    PubMed  CAS  Google Scholar 

  • Koss MP, Yuan NP, Dightman D, Prince RJ, Polacca M, Sanderson B, Goldman D (2003) Adverse childhood exposures and alcohol dependence among seven Native American tribes. Am J Prev Med 25:238–244

    PubMed  Google Scholar 

  • Lansford JE, Malone PS, Stevens KI, Dodge KA, Bates JE, Pettit GS (2006) Developmental trajectories of externalizing and internalizing behaviors: factors underlying resilience in physically abused children. Dev Psychopathol 18:35–55

    PubMed  Google Scholar 

  • Lansford JE, Miller-Johnson S, Berlin LJ, Dodge KA, Bates JE, Pettit GS (2007) Early physical abuse and later violent delinquency: a prospective longitudinal study. Child Maltreat 12:233–245

    PubMed  Google Scholar 

  • Laucht M, Treutlein J, Schmid B, Blomeyer D, Becker K, Buchmann AF, Schmidt MH, Esser G, Jennen-Steinmetz C, Rietschel M, Zimmermann US, Banaschewski T (2009) Impact of psychosocial adversity on alcohol intake in young adults: moderation by the LL genotype of the serotonin transporter polymorphism. Biol Psychiatry 66:102–109

    PubMed  Google Scholar 

  • Laviolette SR, Gallegos RA, Henriksen SJ, van der Kooy D (2004) Opiate state controls bi-directional reward signaling via GABAA receptors in the ventral tegmental area. Nat Neurosci 7:160–169

    PubMed  CAS  Google Scholar 

  • Lippmann M, Bress A, Nemeroff CB, Plotsky PM, Monteggia LM (2007) Long-term behavioural and molecular alterations associated with maternal separation in rats. Eur J Neurosci 25:3091–3098

    PubMed  Google Scholar 

  • Liu D, Diorio J, Tannenbaum B, Caldji C, Francis D, Freedman A, Sharma S, Pearson D, Plotsky PM, Meaney MJ (1997) Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science 277:1659–1662

    PubMed  CAS  Google Scholar 

  • MacMillan H, Fleming J, Trocme N, Boyle M, Wong M, Racine Y et al (1997) Prevalence of child physical and sexual abuse in the community. Results from the Ontario Health Supplement. JAMA 278:131–135

    PubMed  CAS  Google Scholar 

  • MacMillan HL, Georgiades K, Duku EK, Shea A, Steiner M, Niec A, Tanaka M, Gensey S, Spree S, Vella E, Walsh CA, De Bellis MD, Van der Meulen J, Boyle MH, Schmidt LA (2009) Cortisol response to stress in female youths exposed to childhood maltreatment: results of the youth mood project. Biol Psychiatry 66:62–68

    PubMed  Google Scholar 

  • Makris N, Oscar-Berman M, Jaffin SK, Hodge SM, Kennedy DN, Caviness VS, Marinkovic K, Breiter HC, Gasic GP, Harris GJ (2008) Decreased volume of the brain reward system in alcoholism. Biol Psychiatry 64:192–202

    PubMed  CAS  Google Scholar 

  • Matthews K, Robbins TW (2003) Early experience as a determinant of adult behavioural responses to reward: the effects of repeated maternal separation in the rat. Neurosci Biobehav Rev 27:45–55

    PubMed  Google Scholar 

  • McArthur S, McHale E, Dalley JW, Buckingham JC, Gillies GE (2005) Altered mesencephalic dopaminergic populations in adulthood as a consequence of brief perinatal glucocorticoid exposure. J Neuroendocrinol 17:475–482

    PubMed  CAS  Google Scholar 

  • McGowan PO, Sasaki A, D’Alessio AC, Dymov S, Labonté B, Szyf M, Turecki G, Meaney MJ (2009) Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 12:342–348

    PubMed  CAS  Google Scholar 

  • McLaughlin KA, Green JG, Gruber MJ, Sampson NA, Zaslavsky AM, Kessler RC (2010) Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication II: associations with persistence of DSM-IV disorders. Arch Gen Psychiatry 67:124–132

    PubMed  Google Scholar 

  • McQueeny T, Schweinsburg BC, Schweinsburg AD, Jacobus J, Bava S, Frank LR, Tapert SF (2009) Altered white matter integrity in adolescent binge drinkers. Alcohol Clin Exp Res 33:1278–1285

    PubMed  Google Scholar 

  • Meaney MJ, Brake W, Gratton A (2002) Environmental regulation of the development of mesolimbic dopamine systems: a neurobiological mechanism for vulnerability to drug abuse? Psychoneuroendocrinology 27:127–138

    PubMed  CAS  Google Scholar 

  • Meijer OC (2006) Understanding stress through the genome. Stress 9:61–67

    PubMed  CAS  Google Scholar 

  • Mesquita AR, Pêgo JM, Summavielle T, Maciel P, Almeida OF, Sousa N (2007) Neurodevelopment milestone abnormalities in rats exposed to stress in early life. Neuroscience 147:1022–1033

    PubMed  CAS  Google Scholar 

  • Milne BJ, Caspi A, Harrington H, Poulton R, Rutter M, Moffitt TE (2009) Predictive value of family history on severity of illness: the case for depression, anxiety, alcohol dependence, and drug dependence. Arch Gen Psychiatry 66:738–747

    PubMed  Google Scholar 

  • Moffett MC, Vicentic A, Kozel M, Plotsky P, Francis DD, Kuhar MJ (2007) Maternal separation alters drug intake patterns in adulthood in rats. Biochem Pharmacol 73:321–330

    PubMed  CAS  Google Scholar 

  • Moffitt TE, Caspi A, Rutter M (2005) Strategy for investigating interactions between measured genes and measured environments. Arch Gen Psychiatry 62:473–481

    PubMed  CAS  Google Scholar 

  • Monti PM, Miranda R Jr, Nixon K, Sher KJ, Swartzwelder HS, Tapert SF, White A, Crews FT (2005) Adolescence: booze, brains, and behavior. Alcohol Clin Exp Res 29:207–220

    PubMed  Google Scholar 

  • Mullen PE, Martin JL, Anderson JC, Romans SE, Herbison GP (1996) The long-term impact of the physical, emotional, and sexual abuse of children: a community study. Child Abuse Negl 20:7–21

    PubMed  CAS  Google Scholar 

  • Nair A, Vadodaria KC, Banerjee SB, Benekareddy M, Dias BG, Duman RS, Vaidya VA (2007) Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus. Neuropsychopharmacology 32:1504–1519

    PubMed  CAS  Google Scholar 

  • Nelson EC, Heath AC, Lynskey MT, Bucholz KK, Madden PA, Statham DJ et al (2006) Childhood sexual abuse and risks for licit and illicit drug-related outcomes: a twin study. Psychol Med 36:1473–1483

    PubMed  Google Scholar 

  • Nelson EC, Agrawal A, Pergadia ML, Wang JC, Whitfield JB, Saccone FS, Kern J, Grant JD, Schrage AJ, Rice JP, Montgomery GW, Heath AC, Goate AM, Martin NG, Madden PA (2010) H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence. Addict Biol 15:1–11

    PubMed  CAS  Google Scholar 

  • Ney PG, Fung T, Wickett AR (1994) The worst combinations of child abuse and neglect. Child Abuse Negl 18:705–714

    PubMed  CAS  Google Scholar 

  • Nie Z, Schweitzer P, Roberts AJ, Madamba SG, Moore SD, Siggins GR (2004) Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors. Science 303:1512–1514

    PubMed  CAS  Google Scholar 

  • Niemela S, Sourander A, Poikolainen K, Helenius H, Sillanmaki L, Parkkola K, Piha J, Kumpulainen K, Almqvist F, Moilanen I (2006) Childhood predictors of drunkenness in late adolescence among males: a 10-year population-based follow-up study. Addiction 101:512–521

    PubMed  Google Scholar 

  • Oswald LM, Zandi P, Nestadt G, Potash JB, Kalaydjian AE, Wand GS (2006) Relationship between cortisol responses to stress and personality. Neuropsychopharmacology 31:1583–1591

    PubMed  CAS  Google Scholar 

  • Ou XM, Chen K, Shih JC (2006) Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1. J Biol Chem 281:21512–21525

    PubMed  CAS  Google Scholar 

  • Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, Kolachana BS, Egan MF, Mattay VS, Hariri AR, Weinberger DR (2005) 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 8:828–834

    PubMed  CAS  Google Scholar 

  • Pilowsky DJ, Keyes KM, Hasin DS (2009) Adverse childhood events and lifetime alcohol dependence. Am J Public Health 99:258–263

    PubMed  Google Scholar 

  • Plotsky PM, Thrivikraman KV, Nemeroff CB, Caldji C, Sharma S, Meaney MJ (2005) Long-term consequences of neonatal rearing on central corticotropin-releasing factor systems in adult male rat offspring. Neuropsychopharmacology 30:2192–2204

    PubMed  CAS  Google Scholar 

  • Polanczyk G, Caspi A, Williams B, Price TS, Danese A, Sugden K, Uher R, Poulton R, Moffitt TE (2009) Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension. Arch Gen Psychiatry 66:978–985

    PubMed  CAS  Google Scholar 

  • Poulton R, Caspi A, Milne BJ, Thomson WM, Taylor A, Sears MR, Moffitt TE (2002) Association between children's experience of socioeconomic disadvantage and adult health: a life-course study. Lancet 360:1640–1645

    PubMed  Google Scholar 

  • Prichard Z, Mackinnon A, Jorm AF, Easteal S (2008) No evidence for interaction between MAOA and childhood adversity for antisocial behavior. Am J Med Genet B Neuropsychiatr Genet 147:228–232

    Google Scholar 

  • Prom-Wormley EC, Eaves LJ, Foley DL, Gardner CO, Archer KJ, Wormley BK, Maes HH, Riley BP, Silberg JL (2009) Monoamine oxidase A and childhood adversity as risk factors for conduct disorder in females. Psychol Med 39:579–590

    PubMed  CAS  Google Scholar 

  • Pruessner JC, Champagne F, Meaney MJ, Dagher A (2004) Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: a positron emission tomography study using [11C]raclopride. J Neurosci 24:2825–2831

    PubMed  CAS  Google Scholar 

  • Rao U, Chen LA, Bidesi AS, Shad MU, Thomas MA, Hammen CL (2010) Hippocampal changes associated with early-life adversity and vulnerability to depression. Biol Psychiatry 67:357–364

    PubMed  Google Scholar 

  • Ressler KJ, Bradley B, Mercer KB, Deveau TC, Smith AK, Gillespie CF, Nemeroff CB, Cubells JF, Binder EB (2010) Polymorphisms in CRHR1 and the serotonin transporter loci: gene × gene × environment interactions on depressive symptoms. Am J Med Genet B Neuropsychiatr Genet 153B:812–824

    PubMed  CAS  Google Scholar 

  • Robin RW, Chester B, Rasmussen JK, Jaranson JM, Goldman D (1997) Prevalence, characteristics, and impact of childhood sexual abuse in a Southwestern American Indian tribe. Child Abuse Negl 21:769–787

    PubMed  CAS  Google Scholar 

  • Roth TL, Lubin FD, Funk AJ, Sweatt JD (2009) Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol Psychiatry 65:760–769

    PubMed  CAS  Google Scholar 

  • Rothman EF, Edwards EM, Heeren T, Hingson RW (2008) Adverse childhood experiences predict earlier age of drinking onset: results from a representative US sample of current or former drinkers. Pediatrics 122:298–304

    Google Scholar 

  • Roy A, Gorodetsky E, Yuan Q, Goldman D, Enoch M-A (2010) The Interaction of FKBP5, a stress related gene, with childhood trauma increases the risk for attempting suicide. Neuropsychopharmacology 35:1674–1683

    Google Scholar 

  • Sánchez MM, Hearn EF, Do D, Rilling JK, Herndon JG (1998) Differential rearing affects corpus callosum size and cognitive function of rhesus monkeys. Brain Res 812:38–49

    PubMed  Google Scholar 

  • Sánchez M, Noble P, Lyon C, Plotsky P, Davis M, Nemeroff C, Winslow J (2005) Alterations in diurnal cortisol rhythm and acoustic startle response in nonhuman primates with adverse rearing. Biol Psychiatry 57:373–381

    PubMed  Google Scholar 

  • Sapolsky RM (2003) Stress and plasticity in the limbic system. Neurochem Res 28:1735–1742

    PubMed  CAS  Google Scholar 

  • Sapolsky RM, Romero LM, Munck AU (2000) How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev 21:55–89

    PubMed  CAS  Google Scholar 

  • Schilling EA, Aseltine RH Jr, Gore S (2007) Adverse childhood experiences and mental health in young adults: a longitudinal survey. BMC Public Health 7:30

    PubMed  Google Scholar 

  • Schmid B, Blomeyer D, Treutlein J, Zimmermann US, Buchmann AF, Schmidt MH, Esser G, Rietschel M, Banaschewski T, Schumann G, Laucht M (2009) Interacting effects of CRHR1 gene and stressful life events on drinking initiation and progression among 19-year-olds. Int J Neuropsychopharmacol 17:1–12

    Google Scholar 

  • Schulte T, Sullivan EV, Müller-Oehring EM, Adalsteinsson E, Pfefferbaum A (2005) Corpus callosal microstructural integrity influences interhemispheric processing: a diffusion tensor imaging study. Cereb Cortex 15:1384–1392

    PubMed  CAS  Google Scholar 

  • Schwandt ML, Lindell SG, Chen S, Higley JD, Suomi SJ, Heilig M, Barr CS (2010) Alcohol response and consumption in adolescent rhesus macaques: life history and genetic influences. Alcohol 44:67–80

    PubMed  CAS  Google Scholar 

  • Shin SH, Edwards EM, Heeren T (2009) Child abuse and neglect: relations to adolescent binge drinking in the national longitudinal study of Adolescent Health (AddHealth) Study. Addict Behav 34:277–280

    PubMed  Google Scholar 

  • Simpson TL, Miller WR (2002) Concomitance between childhood sexual and physical abuse and substance use problems. A review. Clin Psychol Rev 22:27–77

    PubMed  Google Scholar 

  • Sinha R (2001) How does stress increase risk of drug abuse and relapse? Psychopharmacology (Berl) 158:343–359

    CAS  Google Scholar 

  • Sjoberg RL, Nilsson KW, Wargelius HL, Leppert J, Lindstrom L, Oreland L (2007) Adolescent girls and criminal activity: role of MAOA-LPR genotype and psychosocial factors. Am J Med Genet B Neuropsychiatr Genet 144:159–164

    Google Scholar 

  • Snoek H, Van Goozen SH, Matthys W, Buitelaar JK, van Engeland H (2004) Stress responsivity in children with externalizing behavior disorders. Dev Psychopathol 16:389–406

    PubMed  Google Scholar 

  • Spinelli S, Chefer S, Suomi SJ, Higley JD, Barr CS, Stein E (2009) Early-life stress induces long-term morphologic changes in primate brain. Arch Gen Psychiatry 66:658–665

    PubMed  Google Scholar 

  • Stein MB, Koverola C, Hanna C, Torchia MG, McClarty B (1997) Hippocampal volume in women victimized by childhood sexual abuse. Psychol Med 27:951–959

    PubMed  CAS  Google Scholar 

  • Tarullo AR, Gunnar MR (2006) Child maltreatment and the developing HPA axis. Horm Behav 50:632–639

    PubMed  Google Scholar 

  • Teicher MH, Andersen SL, Polcari A, Anderson CM, Navalta CP, Kim DM (2003) The neurobiological consequences of early stress and childhood maltreatment. Neurosci Biobehav Rev 27:33–44

    PubMed  Google Scholar 

  • Teicher MH, Dumont NL, Ito Y, Vaituzis C, Giedd JN, Andersen SL (2004) Childhood neglect is associated with reduced corpus callosum area. Biol Psychiatry 56:80–85

    PubMed  Google Scholar 

  • Trickett PK, Noll JG, Susman EJ, Shenk CE, Putnam FW (2010) Attenuation of cortisol across development for victims of sexual abuse. Dev Psychopathol 22:165–175

    PubMed  Google Scholar 

  • Tyrka AR, Price LH, Gelernter J, Schepker C, Anderson GM, Carpenter LL (2009) Interaction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic-pituitary-adrenal axis reactivity. Biol Psychiatry 66:681–685

    PubMed  CAS  Google Scholar 

  • Vargas-Perez H, Ting-A Kee R, Walton CH, Hansen DM, Razavi R, Clarke L, Bufalino MR, Allison DW, Steffensen SC, van der Kooy D (2009) Ventral tegmental area BDNF induces an opiate-dependent-like reward state in naive rats. Science 324:1732–1734

    PubMed  CAS  Google Scholar 

  • Vazquez V, Penit-Soria J, Durand C, Besson MJ, Giros B, Daugé V (2006) Brief early handling increases morphine dependence in adult rats. Behav Brain Res 170:211–218

    PubMed  CAS  Google Scholar 

  • Verona E, Sachs-Ericsson N (2005) The intergenerational transmission of externalizing behaviors in adult participants: the mediating role of childhood abuse. J Consult Clin Psychol 73:1135–1145

    PubMed  Google Scholar 

  • Viner RM, Taylor B (2007) Adult outcomes of binge drinking in adolescence: findings from a UK national birth cohort. J Epidemiol Community Health 61:902–907

    PubMed  CAS  Google Scholar 

  • Vogeltanz ND, Wilsnack SC, Harris TR, Wilsnack RW, Wonderlich SA, Kristjanson AF (1999) Prevalence and risk factors for childhood sexual abuse in women: national survey findings. Child Abuse Negl 23:579–592

    PubMed  CAS  Google Scholar 

  • Walker EA, Gelfand A, Katon WJ, Koss MP, Von Korff M, Bernstein D, Russo J (1999) Adult health status of women with histories of childhood abuse and neglect. Am J Med 107:332–329

    PubMed  CAS  Google Scholar 

  • Wand G (2005) The anxious amygdala: CREB signaling and predisposition to anxiety and alcoholism. J Clin Invest 115:2697–2699

    PubMed  CAS  Google Scholar 

  • Waselus M, Nazzaro C, Valentino RJ, Van Bockstaele EJ (2009) Stress-induced redistribution of corticotropin-releasing factor receptor subtypes in the dorsal raphe nucleus. Biol Psychiatry 66:76–83

    PubMed  CAS  Google Scholar 

  • Weaver IC (2009) Shaping adult phenotypes through early life environments. Birth Defects Res C Embryo Today 87:314–326

    PubMed  CAS  Google Scholar 

  • Weaver IC, La Plante P, Weaver S, Parent A, Sharma S, Diorio J, Chapman KE, Seckl JR, Szyf M, Meaney MJ (2001) Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites. Mol Cell Endocrinol 185:205–218

    PubMed  CAS  Google Scholar 

  • Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M, Meaney MJ (2004) Epigenetic programming by maternal behavior. Nat Neurosci 7:847–854

    PubMed  CAS  Google Scholar 

  • White HR, Widom CS (2008) Three potential mediators of the effects of child abuse and neglect on adulthood substance use among women. J Stud Alcohol Drugs 69:337–347

    PubMed  Google Scholar 

  • Widom CS, Brzustowicz LM (2006) MAOA and the “cycle of violence”: childhood abuse and neglect, MAOA genotype, and risk for violent and antisocial behavior. Biol Psychiatry 60:684–689

    PubMed  CAS  Google Scholar 

  • Widom CS, Marmorstein NR, White HR (2006) Childhood victimization and illicit drug use in middle adulthood. Psychol Addict Behav 20:394–403

    PubMed  Google Scholar 

  • Widom CS, White HR, Czaja SJ, Marmorstein NR (2007) Long-term effects of child abuse and neglect on alcohol use and excessive drinking in middle adulthood. J Stud Alcohol Drugs 68:317–326

    Google Scholar 

  • Wilson HW, Widom CS (2009) A prospective examination of the path from child abuse and neglect to illicit drug use in middle adulthood: the potential mediating role of four risk factors. J Youth Adolesc 38:340–354

    PubMed  Google Scholar 

  • Wise RA, Morales M (2010) A ventral tegmental CRF-glutamate-dopamine interaction in addiction. Brain Res 1314:38–43

    PubMed  CAS  Google Scholar 

  • Witt ED (2010) Research on alcohol and adolescent brain development: opportunities and future directions. Alcohol 44:119–124

    PubMed  CAS  Google Scholar 

  • Woon FL, Hedges DW (2008) Hippocampal and amygdala volumes in children and adults with childhood maltreatment-related posttraumatic stress disorder: a meta-analysis. Hippocampus 18:729–736

    PubMed  Google Scholar 

  • Wüst S, Kumsta R, Treutlein J, Frank J, Entringer S, Schulze TG, Rietschel M (2009) Sex-specific association between the 5-HTT gene-linked polymorphic region and basal cortisol secretion. Psychoneuroendocrinology 34:972–982

    PubMed  Google Scholar 

  • Young SE, Smolen A, Hewitt JK, Haberstick BC, Stallings MC, Corley RP, Crowley TJ (2006) Interaction between MAO-A genotype and maltreatment in the risk for conduct disorder: failure to confirm in adolescent patients. Am J Psychiatry 163:1019–1025

    PubMed  Google Scholar 

  • Young-Wolff KC, Kendler KS, Ericson ML, Prescott CA (2010) Accounting for the association between childhood maltreatment and alcohol-use disorders in males: a twin study. Psychol Med Mar 29:1–12

    Google Scholar 

  • Yuan NP, Koss MP, Polacca M, Goldman D (2006) Risk factors for physical assault and rape among six Native American tribes. J Interpers Violence 21:1566–1590

    PubMed  Google Scholar 

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Correspondence to Mary-Anne Enoch.

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This research was supported by the Intramural Research Program of the National Institute on Alcohol Abuse and Alcoholism, NIH.

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Enoch, MA. The role of early life stress as a predictor for alcohol and drug dependence. Psychopharmacology 214, 17–31 (2011). https://doi.org/10.1007/s00213-010-1916-6

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Keywords

  • Abuse
  • Addiction
  • Alcohol
  • Corticotropin
  • Dopamine
  • Gene expression
  • Glucocorticoid
  • HPA axis
  • Stress
  • VTA