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Analysis of licking microstructure provides no evidence for a reduction in reward value following acute or sub-chronic phencyclidine administration

Psychopharmacology volume 209, pages 153–162 (2010)Cite this article

Abstract

Rationale

The N-methyl D-aspartate antagonist phencyclidine (PCP) is purported to mimic the negative, cognitive and positive symptoms of schizophrenia. Thus, acute and sub-chronic PCP treatment in rodents might produce anhedonia, a decrease in the pleasure produced by rewards.

Objectives

Experiment 1 investigated whether acute PCP treatment changes the value of sucrose. A comparison was made to (+)MK-801, a drug often used interchangeably with PCP in preclinical studies. Experiment 2 assessed the effects of withdrawal from sub-chronic PCP treatment on the value of sucrose.

Methods

Experiment 1 examined the dose–response effects of PCP and (+)MK-801 on licking microstructure during sucrose consumption. Experiment 2 assessed the effects of withdrawal from sub-chronic PCP treatment (5 mg/kg twice daily for 7 days), on licking microstructure during sucrose consumption. Locomotor activity testing was carried out in experiment 2 to confirm the sensitisation effect of the PCP regimen on amphetamine-induced hyperlocomotion.

Results

Low to moderate acute doses of PCP and (+)MK-801 increased the amount of sucrose consumed. Higher doses decreased consumption and the number of licks per cluster (cluster size) but also increased the average inter-lick interval, which may indicate motor impairment. There was no evidence that withdrawal from sub-chronic PCP treatment produced decreases in consumption or lick cluster size.

Conclusions

Following acute PCP treatment, we found no evidence of reduced reward value without the presence of confounding motor deficits. Sub-chronic PCP withdrawal also produced no decrease in reward value. Therefore, the current results indicate that neither acute PCP treatment nor sub-chronic PCP withdrawal produce consummatory anhedonia.

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Acknowledgements

Biotechnology and Biological Sciences Research Council Collaborative Award in Science and Engineering co-funded by Eli-Lilly to E.S.L.

Biotechnology and Biological Sciences Research Council New Investigator award to D.M.D.

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Affiliations

  1. School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, CF10 3AT, UK

    Emma S. Lydall & Dominic M. Dwyer

  2. Eli Lilly & Co. Ltd., Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey, GU20 6PH, UK

    Gary Gilmour

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  1. Emma S. Lydall
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Correspondence to Emma S. Lydall.

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Lydall, E.S., Gilmour, G. & Dwyer, D.M. Analysis of licking microstructure provides no evidence for a reduction in reward value following acute or sub-chronic phencyclidine administration. Psychopharmacology 209, 153–162 (2010). https://doi.org/10.1007/s00213-010-1779-x

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Keywords

  • Schizophrenia
  • NMDA antagonists
  • Reward
  • Anhedonia
  • Licking
  • Microstructure