Are attention lapses related to d-amphetamine liking?
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A rich literature suggests that both impulsiveness and drug-induced euphoria are risk factors for drug abuse. However, few studies have examined whether sensitivity to the euphoric effects of stimulants is related to attention lapses, a behavioral measure of inattention sometimes associated with impulsivity.
The aim of the study was to examine ratings of d-amphetamine drug liking among individuals with high, moderate, and low attention lapses.
Ninety-nine healthy volunteers were divided into three equal-sized groups based on their performance on a measure of lapses of attention. The groups, who exhibited low, medium, and high attention lapses (i.e., long reaction times) on a simple reaction time task, were compared on their subjective responses (i.e., ratings of liking and wanting more drug) after acute doses of d-amphetamine (0, 5, 10, and 20 mg).
Subjects who exhibited high lapses liked 20 mg d-amphetamine less than subjects who exhibited low lapses. These subjects also tended to report smaller increases in “wanting more drug” after d-amphetamine.
The findings suggest that participants who exhibit impaired attention may be less sensitive to stimulant-induced euphoria.
KeywordsInattention d-amphetamine Reward Drug liking Subjective effects Dopamine Impulsiveness
The authors thank Margo Meverden and Adam Strohm for their technical contributions.
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