Effect of aspirin on hypothalamic–pituitary–adrenal function and on neuropsychological performance in healthy adults: a pilot study
- 231 Downloads
Hypothalamic–pituitary–adrenal axis dysregulation predicts poor clinical and biochemical response to antidepressants. Antiglucocorticoids have therapeutic benefits but most have a troublesome adverse event profile. Aspects of neuropsychological performance, notably working memory, are susceptible to corticosteroid modulation and are impaired in depression. Aspirin has been shown to attenuate the adrenocorticotropic hormone (ACTH) and cortisol response to physiological challenge suggesting its potential to act as an augmenting agent in depression.
To examine the effect of sub-acute (300 mg daily for 7 days) aspirin pre-treatment on the cortisol awakening response and the effect of acute (600 mg) and sub-acute aspirin on the neuroendocrine and neuropsychological response to the arginine vasopressin analogue, desmopressin.
We demonstrated that aspirin pre-treatment did not attenuate the cortisol or ACTH response to desmopressin but, as hypothesised, significantly reduced the cortisol awakening response and improved working memory.
Further studies to examine the impact of aspirin on neuropsychological performance and HPA axis function are warranted.
KeywordsCortisol ACTH Adrenocorticotropic hormone Arginine vasopressin Neuropsychological Digit span
The authors wish to thank the Northumberland Tyne and Wear NHS Trust, the Mental Health Foundation North-East Branch and the Newcastle Healthcare Charity.
- Benton AL, Hamsher K (1976) Multilingual aphasia examination. University of Iowa, IowaGoogle Scholar
- Cavagnini F, Di Landro A, Maraschini C, Invitti C, Pinto ML (1979) Effect of two prostaglandin synthesis inhibitors, indomethacin and acetylsalicylic acid, on plasma ACTH and cortisol levels in man. Acta Endocrinol (Copenh) 91:666–673Google Scholar
- Gallagher P, Malik N, Newham J, Young AH, Ferrier IN, Mackin P (2008) Antiglucocorticoid treatments for mood disorders. Cochrane Database Syst Rev: CD005168Google Scholar
- Przybyłowski J, Obodyński K, Lewicki C, Kuźniar J, Zaborniak S, Drozd S, Czarny W, Garmulewicz M (2003) The influence of aspirin on exercise-induced changes in adrenocorticotrophic hormone (ACTH), cortisol and aldosterone (ALD) concentrations. Eur J Appl Physiol 89:177–183PubMedCrossRefGoogle Scholar
- Rey A (1964) L’Examen Clinique en Psychologie. Press Universitaire de France, FranceGoogle Scholar
- Venn HR, Watson S, Young AH (2005) Facial expression perception: an objective outcome measure for treatment studies in mood disorders? Int J Neuropsychopharmacol 5:1–17Google Scholar
- von Känel R, Kudielka BM, Metzenthin P, Helfricht S, Preckel D, Haeberli A, Stutz M, Fischer JE (2008) Aspirin, but not propranolol, attenuates the acute stress-induced increase in circulating levels of interleukin-6: a randomized, double-blind, placebo-controlled study. Brain Behav Immun 22:150–157CrossRefGoogle Scholar
- Wechsler D (1981) Wechsler Adult Intelligence Scale—Revised. The Psychological CorporationGoogle Scholar
- Zobel AW, Schulze-Rauschenbach S, von Widdern OC, Metten M, Freymann N, Grasmäder K, Pfeiffer U, Schnell S, Wagner M, Maier W (2004) Improvement of working memory but not declarative memory is correlated with HPA normalization during antidepressant treatment. J Psychiatr Res 38:377–383PubMedCrossRefGoogle Scholar