Abstract
Rationale
The polyamines putrescine, spermidine, and spermine are a group of aliphatic amines that may act as physiological modulators of the N-methyl-d-aspartate (NMDA) receptor, a glutamate receptor implicated in memory formation and consolidation. Arcaine is a competitive antagonist of the polyamine binding site at the NMDA receptor, the post-training administration of which impairs memory of various tasks.
Objectives
In this study, we investigated whether the administration of arcaine and MK-801 alters the memory of the step-down inhibitory avoidance task, and whether the effects of these NMDA antagonists involve state-dependency mechanisms, in adult male Wistar rats.
Results
The administration of arcaine (30 mg/kg, i.p.) or MK-801 (0.03 mg/kg, i.p.) immediately after training impaired inhibitory avoidance performance at testing. Arcaine- and MK-801-induced performance impairment was reversed by the administration of arcaine (30 mg/kg, i.p.) and MK-801 (0.03 mg/kg, i.p.), respectively, 30 min before testing. Response transfer also occurred if arcaine substituted MK-801 at testing, and vice-versa.
Conclusion
These results suggest that arcaine and MK-801 induce state-dependent recall and that, probably due to their ability to decrease NMDA receptor function, one drug can substitute for the other at testing, demonstrating a cross-state dependency between arcaine and MK-801.
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Acknowledgments
The authors thank Dr. Juliano Ferreira for the helpful suggestions, and Paulino Aguiar and Rinaldo Moreira for competent technical support. This study was supported by CNPq (475131/04-5, 477836/2007-0). K Camera is recipient of a CAPES fellowship CF Mello and MA Rubin are recipients of CNPq productivity fellowships (500120/2003-0, 500096/2003-1, 301558/2007-8). All the experiments complied with the current laws of Brazil.
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Ceretta, A.P.C., Camera, K., Mello, C.F. et al. Arcaine and MK-801 make recall state-dependent in rats. Psychopharmacology 201, 405–411 (2008). https://doi.org/10.1007/s00213-008-1304-7
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DOI: https://doi.org/10.1007/s00213-008-1304-7