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Table 2 An overview of 5-HT, 5-HIAA, and 5-HIAA/5-HT turnover levels in frontal cortex and hippocampus

From: Acute tryptophan depletion dose dependently impairs object memory in serotonin transporter knockout rats

Brain area Treatment Genotype 5-HIAA (nmol/g) Sign. 5-HT (nmol/g) Sign. 5-HIAA/5-HT Sign.
Fr cortex Untreated SERT+/+ 1.19 a 2.74 a 0.46  
Fr cortex Untreated SERT+/− 1.01 a 2.67 a 0.40  
Fr cortex Untreated SERT−/− 0.63   1.39   0.46  
Fr cortex TRP+ SERT+/+ 0.99 a 3.38 a 0.31  
Fr cortex TRP+ SERT+/− 0.98 a 3.68 a, b 0.27  
Fr cortex TRP+ SERT−/− 0.51   1.90   0.29  
F cortex TRP− 100 g SERT+/+ 0.65 a, b, c 2.21 a, b, c 0.30 a, b
Fr cortex TRP− 100 g SERT+/− 0.63 a, b 2.16 a, b 0.30 a, b
Fr cortex TRP− 100 g SERT−/− 0.35 b 0.51 b, c 0.74 b, c
Hippocampus Untreated SERT+/+ 1.77 a 1.83 a 1.06  
Hippocampus Untreated SERT+/− 1.52 a 1.82 a 0.86  
Hippocampus Untreated SERT−/− 0.92   0.79   1.26  
Hippocampus TRP+ SERT+/+ 1.49 a 2.11 a 0.73  
Hippocampus TRP+ SERT+/− 1.33 a 2.48 a, b 0.58  
Hippocampus TRP+ SERT−/− 0.51   1.90   0.29  
Hippocampus TRP− 100 g SERT+/+ 0.84 a, b, c 1.56 a 0.56 a, b
Hippocampus TRP− 100 g SERT+/− 0.80 a, b, c 1.37 a, c 0.59 a
Hippocampus TRP− 100 g SERT−/− 0.35 B 0.51 b, c 0.74 b, c
  1. a Significantly different from SERT−/− rats, b significantly different from untreated group with the same genotype, c significantly different from TRP+ treated group with the same genotype