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Intra-accumbens injections of the adenosine A2A agonist CGS 21680 affect effort-related choice behavior in rats

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Abstract

Rationale

Nucleus accumbens dopamine (DA) participates in the modulation of instrumental behavior, including aspects of behavioral activation and effort-related choice behavior. Rats with impaired accumbens DA transmission reallocate their behavior away from food-reinforced activities that have high response requirements and instead select less-effortful types of food-seeking behavior. Although accumbens DA is considered a critical component of the brain circuitry regulating effort-related processes, emerging evidence also implicates adenosine A2A receptors.

Objective

The present work was undertaken to test the hypothesis that accumbens A2A receptor stimulation would produce effects similar to those produced by DA depletion or antagonism.

Materials and methods

Three experiments assessed the effects of the adenosine A2A agonist CGS 21680 on performance of a concurrent choice task (lever pressing for preferred food vs. intake of less preferred chow) that is known to be sensitive to DA antagonists and accumbens DA depletions.

Results

Systemic injections of CGS 21680 reduced lever pressing but did not increase feeding. In contrast, bilateral infusions of the adenosine A2A receptor agonist CGS 21680 (6.0–24.0 ng) into the nucleus accumbens decreased lever pressing for the preferred food but substantially increased consumption of the less preferred chow. Injections of CGS 21680 into a control site dorsal to the accumbens were ineffective.

Conclusions

Taken together, these results are consistent with the hypothesis that local stimulation of adenosine A2A receptors in nucleus accumbens produces behavioral effects similar to those induced by accumbens DA depletions. Accumbens adenosine A2A receptors appear to be a component of the brain circuitry regulating effort-related choice behavior.

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Acknowledgments

This research was supported by a grant to JDS from the United States NIH/NIMH (MH078023-01A1). L. Font was supported by a fellowship from Generalitat Valenciana (Conselleria d’ Empresa, Universitat i Ciencia), Spain.

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Author notes

  1. Laura Font

    Present address: Area de Psicobiologia, Universitat Jaume I., Castellón, 12071, Spain

  2. Susana Mingote

    Present address: Department of Molecular Therapeutics, Columbia University, New York, NY, 10032, USA

  3. Mariana Pereira

    Present address: Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, 07102, USA

Authors and Affiliations

  1. Department of Psychology, University of Connecticut, Storrs, CT, 06269-1020, USA

    Laura Font, Susana Mingote, Andrew M. Farrar, Mariana Pereira, Lila Worden, Colin Stopper, Russell G. Port & John D. Salamone

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Font, L., Mingote, S., Farrar, A.M. et al. Intra-accumbens injections of the adenosine A2A agonist CGS 21680 affect effort-related choice behavior in rats. Psychopharmacology 199, 515–526 (2008). https://doi.org/10.1007/s00213-008-1174-z

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