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Participation of hippocampal ionotropic glutamate receptors in histamine H1 antagonist-induced memory deficit in rats

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Abstract

Rationale

Pyrilamine, a selective histamine H1 antagonist, impaired spatial memory, and decreased hippocampal theta activity during a radial maze task.

Objective

We investigated the ameliorative effects of glutamatergic drugs on pyrilamine-induced spatial memory deficit and the decrease in hippocampal theta activity in rats.

Materials and methods

Drug effects were measured using an eight-arm radial maze with four arms baited. Hippocampal theta rhythm during the radial maze task was also recorded with a polygraph system using a telemetric technique.

Results

Intraperitoneal injection of pyrilamine (35 mg/kg) resulted in impaired reference and working memory in the radial maze task and a decrease in the amplitude and power of hippocampal theta waves. The working memory deficit and the decrease in hippocampal theta power were antagonized by intrahippocampal injection of d-cycloserine (1 μg/side), spermidine (10 μg/side), spermine (10 μg/side), aniracetam (1 μg/side), and 1-(1,3-benzodioxol-5-ylcarbonyl) piperidine (1-BCP) (1 μg/side), but not concanavalin A.

Conclusion

These results clearly indicate that H1 antagonist-induced working memory deficit, and the decrease in hippocampal theta activity was closely associated with hippocampal glutamatergic neurotransmission mediated by N-methyl-d-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.

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Authors and Affiliations

  1. Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8530, Japan

    Takayoshi Masuoka, Shunsuke Saito & Chiaki Kamei

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  1. Takayoshi Masuoka
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  2. Shunsuke Saito
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  3. Chiaki Kamei
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Correspondence to Chiaki Kamei.

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Masuoka, T., Saito, S. & Kamei, C. Participation of hippocampal ionotropic glutamate receptors in histamine H1 antagonist-induced memory deficit in rats. Psychopharmacology 197, 107–114 (2008). https://doi.org/10.1007/s00213-007-1013-7

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  • DOI: https://doi.org/10.1007/s00213-007-1013-7

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