MDMA and alcohol effects, combined and alone, on objective and subjective measures of actual driving performance and psychomotor function
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The party drug ecstasy is frequently used in combination with other drugs like marihuana and alcohol. In addition, a substantial proportion of the MDMA users has claimed to drive a car when under the influence of MDMA and/or other drugs.
To assess the effects of MDMA and alcohol, combined and alone, on actual driving performance and laboratory tasks related to driving.
Eighteen healthy subjects participated in a double-blind, placebo-controlled, six-way cross-over study. Treatments consisted of MDMA 0, 75, and 100 mg with and without alcohol, aiming at 0.06 mg/ml BAC. Laboratory tests (critical tracking task, object movement estimation task) were conducted between 1.5 and 2 h postdrug (0.5 and 1 h postalcohol). Actual driving tests (road tracking test, car-following test) were conducted between 3 and 5 h postdrug (2 and 4 h postalcohol). Subjects completed the addiction research center inventory (ARCI) and rated their driving quality and mental effort during driving.
Alcohol alone impaired critical tracking performance, as well as a number of actual driving performance parameters [i.e., standard deviation of lateral position (SDLP), brake reaction time, and coherence]. MDMA alone reduced SDLP and standard deviation of speed. MDMA significantly moderated alcohol induced impairment of road tracking performance but did not affect alcohol impairments of car-following and laboratory task performance. Subjective data seemed to support objective data.
MDMA moderated the impairing effects of a low dose of alcohol on road tracking performance but it could not overcome alcohol-induced impairment on other aspects of driving behavior or driving related performance.
KeywordsActual driving performance MDMA Alcohol
We would like to thank Gert De Boeck and Marleen Laloup from NICC, Brussels, for analyzing MDMA blood plasma samples. We also would like to thank Kirsten Schuer, Lisa Willems, and Anita van Oers for their relative contribution to the study. This work was conducted as part of the IMMORTAL research consortium funded by EU grant GMA1-2000-27043.
- Hernandez-Lopez C, Farre M, Roset PN, Menoyo E, Pizarro N, Ortuno J, Torrens M, Cami J, de la Torre R (2002) 3,4-Methylenedioxymethamphetamine (ecstasy) and alcohol interactions in humans: psychomotor performance, subjective effects, and pharmacokinetics. J Pharmacol Exp Ther 300:236-244PubMedCrossRefGoogle Scholar
- Jex HR, McDonnell JD, Phatak AV (1966) A “critical” tracking task for man-machine research related to the operator’s effective delay time. I. Theory and experiments with a first-order divergent controlled element. NASA CR-616. NASA Contract Rep NASA CR: 1–105Google Scholar
- Lamers CT, Ramaekers JG, Muntjewerff ND, Sikkema KL, Samyn N, Read NL, Brookhuis KA, Riedel WJ (2003) Dissociable effects of a single dose of ecstasy (MDMA) on psychomotor skills and attentional performance. J Psychopharmacol (Oxford, England) 17:379–387Google Scholar
- O’Hanlon JF (1984) Driving performance under the influence of drugs: rationale for, and application of, a new test. BJCP Br J Clin Pharmacol 18(Suppl 1):121s–129sGoogle Scholar
- Ramaekers JG, Kuypers KPC, Samyn N (2006) Stimulant effects of MDMA 75 mg and methylphenidate 20 mg on actual driving during intoxication and withdrawal. Addiction (in press)Google Scholar
- Read N, Ward N, Parkes A (2000) The role of dynamic tests in assessing the fitness to drive of healthy and cognitively impaired elderly. J Traffic Med 28:34S–35SGoogle Scholar
- Riley SC, James C, Gregory D, Dingle H, Cadger M (2001) Patterns of recreational drug use at dance events in Edinburgh, Scotland. Addiction (Abingdon, England) 96:1035–1047Google Scholar
- Schifano F (1995) Dangerous driving and MDMA (“ecstasy”) abuse. Journal Serotonin Res 1:53–57Google Scholar
- World Medical Organization. Declaration of Helsinki. Br Med J (7 December) 1996;313(7070):1448–1499Google Scholar
- Zijlstra F (1993) Efficiency in work behavior. A design approach for modern tools. University of Technology, Delft, The NetherlandsGoogle Scholar