Effects of DHEA administration on episodic memory, cortisol and mood in healthy young men: a double-blind, placebo-controlled study
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Dehydroepiandrosterone (DHEA) has been reported to enhance cognition in rodents, although there are inconsistent findings in humans.
The aim of this study was to investigate the effects of DHEA administration in healthy young men on episodic memory and its neural correlates utilising an event-related potential (ERP) technique.
Twenty-four healthy young men were treated with a 7-day course of oral DHEA (150 mg b.d.) or placebo in a double blind, random, crossover and balanced order design. Subjective mood and memory were measured using visual analogue scales (VASs). Cortisol concentrations were measured in saliva samples. ERPs were recorded during retrieval in an episodic memory test. Low-resolution brain electromagnetic tomography (LORETA) was used to identify brain regions involved in the cognitive task.
DHEA administration led to a reduction in evening cortisol concentrations and improved VAS mood and memory. Recollection accuracy in the episodic memory test was significantly improved following DHEA administration. LORETA revealed significant hippocampal activation associated with successful episodic memory retrieval following placebo. DHEA modified ERPs associated with retrieval and led to a trend towards an early differential activation of the anterior cingulate cortex (ACC).
DHEA treatment improved memory recollection and mood and decreased trough cortisol levels. The effect of DHEA appears to be via neuronal recruitment of the steroid sensitive ACC that may be involved in pre-hippocampal memory processing. These findings are distinctive, being the first to show such beneficial effects of DHEA on memory in healthy young men.
KeywordsDHEA Cortisol Episodic memory Recognition Mood Event-related potentials (ERPs) Low-resolution brain electromagnetic tomography (LORETA)
We are grateful for the support of the Aga Khan Foundation who provided a Ph.D. scholarship to HAA. This study was supported by the Medical Research Council (UK) via a Clinical Scientific Fellowship award to RHMcAW.
- Annett M (1967) The binomial distribution of right, mixed and left handedness. Q J Exp Psychol 19(4):327–333Google Scholar
- Barnhart KT, Freeman E, Grisso JA, Rader DJ, Sammel M, Kapoor S, Nestler JE (1999) The effect of dehydroepiandrosterone supplementation to symptomatic perimenopausal women on serum endocrine profiles, lipid parameters, and health-related quality of life. J Clin Endocrinol Metab 84:3896–3902CrossRefPubMedGoogle Scholar
- Baulieu EE (1997) Neurosteroids: of the nervous system, by the nervous system, for the nervous system. Recent Prog Horm Res 52TY-JOUR:1–32Google Scholar
- Baulieu EE, Thomas G, Legrain S, Lahlou N, Roger M, Debuire B, Faucounau V, Girard L, Hervy MP, Latour F, Leaud MC, Mokrane A, Ferrandi H, Trivalle C, De Lacharriere O, Nouveau S, Rakoto-Arison B, Souberbielle JC, Raison J, Le Bouc Y, Raynaud A, Girerd X, Foretteg F (2000) Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEage study to a sociobiomedical issue. Proc Natl Acad Sci U S A 97:4279–4284CrossRefPubMedGoogle Scholar
- Huppert FA, van Niekerk JK (2001) Dehydroepiandrosterone (DHEA) supplementation for cognitive function. Cochrane Database Syst Rev (Online: Update Software) CD000304Google Scholar
- Kucera H, Francis WN (1967) Computational analysis of present-day American English. Brown University Press, Providence (RI)Google Scholar
- Lapchak PA, Araujo DM (2001) Preclinical development of neurosteroids as neuroprotective agents for the treatment of neurodegenerative diseases. Int Rev Neurobiol 46TY-JOUR:379–397Google Scholar
- Majewska MD (1995) Neuronal actions of dehydroepiandrosterone. Possible roles in brain development, aging, memory, and affect. Ann N Y Acad Sci Vol 774TY-JOUR 111–120Google Scholar
- Morales AJ, Haubrich RH, Hwang JY, Asakura H, Yen SS (1998) The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women. Clin Endocrinol (Oxf) 49:421–432CrossRefGoogle Scholar
- Seeck M, Lazeyras F, Michel CM, Blanke O, Gericke CA, Ives J, Delavelle J, Golay X, Haenggeli CA, de Tribolet N, Landis T (1998) Non-invasive epileptic focus localization using EEG-triggered functional MRI and electromagnetic tomography. Electroencephalogr Clin Neurophysiol 106:508–512CrossRefPubMedGoogle Scholar
- Talairach J, Tournoux P (1988) Co-planar stereotaxic atlas of the human brain. Thieme, StuttgartGoogle Scholar
- Wolf OT, Neumann O, Hellhammer DH, Geiben AC, Strasburger CJ, Dressendorfer RA, Pirke KM, Kirschbaum C (1997) Effects of a two-week physiological dehydroepiandrosterone substitution on cognitive performance and well-being in healthy elderly women and men. J Clin Endocrinol Metab 82:2363–2367CrossRefPubMedGoogle Scholar