, Volume 182, Issue 1, pp 1–8 | Cite as

Effects of caffeine on performance and mood: withdrawal reversal is the most plausible explanation

  • Jack E. JamesEmail author
  • Peter J. Rogers



Although it is widely believed that caffeine can enhance human performance and mood, the validity of this belief has been questioned, giving rise to debate. The central question is whether superior performance and mood after caffeine represent net benefits, or whether differences between caffeine and control conditions are due to reversal of adverse withdrawal effects.


To provide a focussed review of relevant experimental studies with the aim of clarifying current understanding regarding the effects of caffeine on human performance and mood.


To avoid the shortcomings of standard placebo-controlled studies, which are ambiguous due to failure to control for the confounding influence of withdrawal reversal, three main experimental approaches have been employed: studies that compare consumers and low/non-consumers, pre-treatment and ad lib consumption studies, and long-term withdrawal studies.


Of the three approaches, only long-term withdrawal studies are capable of unambiguously revealing the net effects of caffeine. Overall, there is little evidence of caffeine having beneficial effects on performance or mood under conditions of long-term caffeine use vs abstinence. Although modest acute effects may occur following initial use, tolerance to these effects appears to develop in the context of habitual use of the drug.


Appropriately controlled studies show that the effects of caffeine on performance and mood, widely perceived to be net beneficial psychostimulant effects, are almost wholly attributable to reversal of adverse withdrawal effects associated with short periods of abstinence from the drug.


Caffeine Performance Mood Sleep restriction Withdrawal reversal Fatigue Alertness 


  1. Alsense K, Deckert J, Sand P, de Wit H (2003) Association between A2A receptor gene polymorphisms and caffeine-induced anxiety. Neuropsychopharmacology 28:1694–1702PubMedCrossRefGoogle Scholar
  2. Bruce M, Scott N, Shine P, Lader M (1991) Caffeine withdrawal: a contract of withdrawal symptoms in normal subjects who have abstained from caffeine for 24 hours and for 7 days. J Psychopharmacol 5:129–134CrossRefGoogle Scholar
  3. Chait LD, Griffiths RR (1983) Effects of caffeine on cigarette smoking and subjective response. Clin Pharmacol Ther 34:612–622PubMedCrossRefGoogle Scholar
  4. Christopher G, Sutherland D, Smith A (2005) Effects of caffeine in non-withdrawn volunteers. Hum Psychopharmacol Clin Exp 20:47–53CrossRefGoogle Scholar
  5. Denaro CP, Brown CR, Jacob PI, Benowitz NL (1991) Effects of caffeine with repeated dosing. Eur J Clin Pharmacol 40:273–278PubMedCrossRefGoogle Scholar
  6. Garrett BE, Griffiths RR (1998) Physical dependence increases the relative reinforcing effects of caffeine versus placebo. Psychopharmacology 139:195–202CrossRefPubMedGoogle Scholar
  7. Gilliland K, Bullock W (1984) Caffeine: a potential drug of abuse. Haworth, New YorkGoogle Scholar
  8. Goldstein A, Kaizer S, Whitby O (1969) Psychotropic effects of caffeine in man. IV. Quantitative and qualitative differences associated with habituation to coffee. Clin Pharmacol Ther 10:489–497PubMedGoogle Scholar
  9. Griffiths RR, Bigelow GE, Liebson IA (1986) Human coffee drinking: reinforcing and physical dependence producing effects of caffeine. J Pharmacol Exp Ther 239:416–425PubMedGoogle Scholar
  10. Griffiths RR, Juliano LM, Chausmer AL (2003) Caffeine: pharmacology and clinical effects. In: Graham AW, Schultz TK, Mayo-Smith MF, Ries RK, Wilford BB (eds) Principles of addiction medicine, 3rd edn. American Society of Addiction Medicine, Chevy Chase, MD, pp 134–193Google Scholar
  11. Haskell CF, Kennedy DO, Wesnes KA, Scholey AB (2005) Cognitive and modd improvements of caffeine in habitual consumers and habitual non-consumers of caffeine. Psychopharmacology (in press)Google Scholar
  12. Heatherley SV, Hancock KMF, Rogers PJ (2005a) Psychostimulant and other effects of caffeine in 9- to 11-year-old children. J Child Psychol Psychiatry (in press)Google Scholar
  13. Heatherley SV, Hayward RC, Seers HE, Rogers PJ (2005b) Cognitive and psychomotor performance, mood, and pressor effects of caffeine after 4, 6 and 8 h caffeine abstinence. Psychopharmacology 178:461–470PubMedCrossRefGoogle Scholar
  14. Hughes JR, Oliveto AH, Bickel WK, Higgins ST, Badger GJ (1993) Caffeine self-administration and withdrawal: incidence, individual differences and interrelationships. Drug Alcohol Depend 32:239–246CrossRefPubMedGoogle Scholar
  15. James JE (1990) The influence of user status and anxious disposition on the hypertensive effects of caffeine. Int J Psychophysiol 10:171–179PubMedCrossRefGoogle Scholar
  16. James JE (1994a) Does caffeine enhance or merely restore degraded psychomotor performance? Neuropsychobiology 30:124–125PubMedGoogle Scholar
  17. James JE (1994b) Psychophysiological effects of habitual caffeine consumption. Int J Behav Med 1:247–263PubMedCrossRefGoogle Scholar
  18. James JE (1995) Caffeine and psychomotor performance revisited. Neuropsychobiology 31:202–203PubMedGoogle Scholar
  19. James JE (1997) Understanding caffeine: a biobehavioral analysis. Sage, Thousand Oaks, CAGoogle Scholar
  20. James JE (1998) Acute and chronic effects of caffeine on performance, mood, headache, and sleep. Neuropsychobiology 38:32–41CrossRefPubMedGoogle Scholar
  21. James JE (2003) Caffeine, mental performance and mood. In: Watson D (ed) Performance functional foods. Woodhead, London, pp 168–194Google Scholar
  22. James JE (2004) A critical review of dietary caffeine and blood pressure: a relationship that should be taken more seriously. Psychosom Med 66:31–71CrossRefPubMedGoogle Scholar
  23. James JE, Gregg ME (2004a) Effects of dietary caffeine on mood when rested and sleep restricted. Hum Psychopharmacol Clin Exp 19:333–341CrossRefGoogle Scholar
  24. James JE, Gregg ME (2004b) Hemodynamic effects of dietary caffeine, sleep restriction, and laboratory stress. Psychophysiol 41:914–923CrossRefGoogle Scholar
  25. James JE, Paull I, Cameron-Traub E, Miners JO, Lelo A, Birkett DJ (1988) Biochemical validation of self-reported caffeine consumption during caffeine fading. J Behav Med 11:15–30PubMedCrossRefGoogle Scholar
  26. James JE, Gregg ME, Kane M, Harte F (2005) Dietary caffeine, performance and mood: enhancing and restorative effects after controlling for withdrawal relief. Neuropsychobiology 52:1–10PubMedCrossRefGoogle Scholar
  27. Juliano LM, Griffiths RR (2004) A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features. Psychopharmacology 176:1–29CrossRefPubMedGoogle Scholar
  28. Lelo A, Miners JO, Robson R, Birkett DJ (1986a) Assessment of caffeine exposure: caffeine content of beverages, caffeine intake, and plasma concentrations of methylxanthines. Clin Pharmacol Ther 39:54–59PubMedCrossRefGoogle Scholar
  29. Lelo A, Miners JO, Robson RA, Birkett DJ (1986b) Quantitative assessment of caffeine partial clearances in man. Br J Clin Pharmacol 22:183–186PubMedGoogle Scholar
  30. Lieberman HR, Wurtman RJ, Emde GG, Roberts C, Coviella ILG (1987) The effects of low doses of caffeine on human performance and mood. Psychopharmacol 152:167–173CrossRefGoogle Scholar
  31. Mitchell SH, de Wit H, Zacny JP (1995) Caffeine withdrawal symptoms and self-administration following caffeine deprivation. Pharmacol Biochem Behav 51:941–945CrossRefPubMedGoogle Scholar
  32. Mumford GK, Evans SM, Kaminski BJ, Preston KL, Sannerud DC, Silverman K, Griffiths RR (1994) Discriminative stimulus and subjective effects of theobromine and caffeine in humans. Psychopharmacology 115:1–8PubMedCrossRefGoogle Scholar
  33. Pfeifer RW, Notari RE (1988) Predicting caffeine plasma concentrations resulting from consumption of food or beverages: a simple method and its origin. Drug Intel Clin Pharm 22:953–959Google Scholar
  34. Phillips-Bute BG, Lane JD (1998) Caffeine withdrawal symptoms following brief caffeine deprivation. Physiol Behav 63:35–39CrossRefGoogle Scholar
  35. Reyner LA, Horne JA (2002) Efficacy of a ‘functional energy drink’ in counteracting driver sleepiness. Physiol Behav 75:331–335PubMedCrossRefGoogle Scholar
  36. Richardson NJ, Rogers PJ, Elliman NA, O'Dell RJ (1995) Mood and performance effects of caffeine in relation to acute and chronic caffeine deprivation. Pharmacol Biochem Behav 52:313–320CrossRefPubMedGoogle Scholar
  37. Robelin M, Rogers PJ (1998) Mood and psychomotor performance effects of the first, but not of subsequent, cup-of-coffee equivalent doses of caffeine consumed after overnight caffeine abstinence. Behav Pharmacol 9:611–618PubMedCrossRefGoogle Scholar
  38. Robertson D, Wade D, Workman R, Woosley RL, Oates JA (1981) Tolerance to the humoral and hemodynamic effects of caffeine in man. J Clin Invest 67:1111–1117PubMedCrossRefGoogle Scholar
  39. Rogers PJ, Dernoncourt C (1998) Regular caffeine consumption: a balance of adverse and beneficial effects for mood and psychomotor performance. Pharmacol Biochem Behav 59:1039–1045PubMedCrossRefGoogle Scholar
  40. Rogers PJ, Richardson NJ, Elliman NA (1995) Overnight caffeine abstinence and negative reinforcement of preference for caffeine-containing drinks. Psychopharmacology 120:457–462PubMedCrossRefGoogle Scholar
  41. Rogers PJ, Stephens S, Day JEL (1998) Contrasting performance effects of caffeine after overnight and chronic caffeine withdrawal. J Psychopharmacol 12:A13Google Scholar
  42. Rogers PJ, Martin J, Smith C, Heatherley SV, Smit HJ (2003) Absence of reinforcing, mood and psychomotor performance effects of caffeine in habitual non-consumers of caffeine. Psychopharmacology 167:54–62PubMedGoogle Scholar
  43. Rogers PJ, Heatherley SV, Hayward RC, Sears HE, Hill J, Kane M (2005) Effects of caffeine and caffeine withdrawal on mood and cognitive performance degraded by sleep restriction. Psychopharmacology 179:742–752PubMedCrossRefGoogle Scholar
  44. Silverman K, Griffiths RR (1992) Low-dose caffeine discrimination and self-reported mood effects in normal volunteers. J Exp Anal Behav 57:91–107PubMedCrossRefGoogle Scholar
  45. Silverman K, Mumford GK, Griffiths RR (1994) Enhancing caffeine reinforcement by behavioral requirements following drug ingestion. Psychopharmacology 114:424–432PubMedCrossRefGoogle Scholar
  46. Smit HJ, Rogers PJ (2000) Effects of low doses of caffeine on cognitive performance, mood and thirst in low and higher caffeine consumers. Psychopharmacology 152:167–173CrossRefPubMedGoogle Scholar
  47. Smith AP (1995) Caffeine, caffeine withdrawal and psychomotor performance: a reply to James. Neuropsychobiology 31:200–201PubMedGoogle Scholar
  48. Smith AP (2002) Effects of caffeine on human behaviour. Food Chem Toxicol 40:1243–1255PubMedCrossRefGoogle Scholar
  49. Streufert S, Pogash R, Miller J, Gingrich D, Landis R, Lonardi L, Severs W, Roache JD (1995) Effects of caffeine deprivation on complex human functioning. Psychopharmacology 118:377–384PubMedCrossRefGoogle Scholar
  50. Tinley EM, Yeomans MR, Durlach PJ (2003) Caffeine reinforces flavour preference in caffeine-dependent, but not long-term withdrawn, caffeine consumers. Psychopharmacology 166:416–423PubMedGoogle Scholar
  51. van Duinen H, Lorist MM, Zijdewind I (2005) The effect of caffeine on cognitive task performance and motor fatigue. Psychopharmacology (in press)Google Scholar
  52. Warburton DM (1995) Effects of caffeine on cognition and mood without caffeine abstinence. Psychopharmacology 119:66–70PubMedCrossRefGoogle Scholar
  53. Warburton DM, Bersellini E, Sweeney E (2001) An evaluation of a caffeinated taurine drink on mood, memory and information processing in healthy volunteers without caffeine abstinence. Psychopharmacology 158:322–328PubMedCrossRefGoogle Scholar
  54. Watson JM, Lunt MJ, Morris S, Weiss MJ, Hussey D, Kerr D (2000) Reversal of caffeine withdrawal by ingestion of a soft beverage. Pharmacol Biochem Behav 66:15–18PubMedCrossRefGoogle Scholar
  55. Yeomans MR, Spetch H, Rogers PJ (1998) Conditioned flavour preference negatively reinforced by caffeine in human volunteers. Psychopharmacology 137:401–409CrossRefPubMedGoogle Scholar
  56. Yeomans MR, Ripley T, Davies LH, Rusted JM, Rogers PJ (2002) Effects of caffeine on performance and mood depend on the level of caffeine abstinence. Psychopharmacology 164:241–249CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  1. 1.Department of PsychologyNational University of IrelandGalwayIreland
  2. 2.Department of Experimental PsychologyUniversity of BristolBristolUK

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