Currently available therapy for depression treatment is often associated with several undesirable side effects, and it is effective only in a certain portion of the population. Therefore, the identification of alternative therapeutic tools for the treatment of depression is still needed.
The present study analyzed the possible antidepressant-like effects of the Brazilian medicinal plant, Trichilia catigua, in rodents. Attempts were also made to investigate some of the possible mechanisms implicated in its actions.
The antidepressant-like effects of T. catigua extract were assessed in two species of rodents (mice and rats) by means of in vivo (forced swimming test) and in vitro (monoamine reuptake and release in synaptosomal preparations) approaches.
Acute oral treatment with the extract of T. catigua produced antidepressant-like effects in the forced swimming model in both mice and rats. Anti-immobility actions of T. catigua extract in mice were significantly reversed by haloperidol or by chlorpromazine, but not by pimozide, ketanserin, spiroxatrine or p-chlorophenylalanine. In vitro, T. catigua extract concentration-dependently inhibited the uptake and increased the release of serotonin, and especially of dopamine, from rat brain synaptosomal preparations.
The present study provides convincing evidence for a dopamine-mediated antidepressant-like effect of the active principle(s) present in the hydroalcoholic extract of T. catigua in mice and rats when in vivo and in vitro strategies were employed. Therefore, a standardized T. catigua extract or its purified constituents could be of potential interest for the treatment of depressive disorders.
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Antunes E, Gordo WM, de Oliveira JF, Teixeira CE, Hyslop S, De Nucci G (2001) The relaxation of isolated rabbit corpus cavernosum by the herbal medicine Catuama and its constituents. Phytother Res 15:416–421
Bennett BA, Paris JM, Pecora JR (1993) Stimulant-induced alterations in dopaminergic and serotonergic function in fetal raphe neurons. Brain Res Bull 31:471–476
Bosker FJ, Westernik BH, Cremers TI, Gerrits M, Van Der Hart MG, Kuipers SD, Van Der Pompé G, Ter Horst GJ, Den Boer JA, Korf J (2004) Future antidepressants: what is in the pipeline and what is missing? CNS Drugs 18:705–732
Cabrini DA, Calixto JB (1997) Herbal Catuama induces endothelium-dependent and -independent vasorelaxation action on isolated vessels from rats, guinea-pigs and rabbits. Phytother Res 11:32–38
Campos MM, Fernandes ES, Ferreira J, Bortolanza LB, Santos AR, Calixto JB (2004) Pharmacological and neurochemical evidence for antidepressant-like effects of the herbal product Catuama. Pharmacol Biochem Behav 78:757–764
Chatterjee SS, Bhattacharya SK, Wonnemann M, Singer A, Muller WE (1998) Hyperforin as a possible antidepressant component of Hypericum extracts. Life Sci 63:499–510
D'Aquila PS, Collu M, Gessa GL, Serra G (2000) The role of dopamine in the mechanism of action of antidepressant drugs. Eur J Pharmacol 405:365–373
Detke MJ, Rickels M, Lucki I (1995) Active behaviors in the rat forced swimming test differentially produced by serotoninergic and noradrenergic antidepressants. Psychopharmacology 121:66–72
Erfurth A, Michael N, Stadtland C, Arolt V (2002) Bupropion as add-on strategy in difficult-to-treat bipolar depressive patients. Neuropsychobiology 45(Suppl 1):33–36
Feighner JP (1999) Mechanism of action of antidepressant medications. J Clin Psychiatry 60(Suppl 4):4–11
Gavioli EC, Vaughan CW, Marzola G, Guerrini R, Mitchell VA, Zucchini S, De Lima TCM, Rae GA, Salvadori S, Regoli D, Calo G (2004) Antidepressant-like effects of the nociceptin/orphanin FQ receptor antagonist UFP-101: new evidence from rats and mice. Naunyn Schmiedeberg's Arch Pharmacol 369:547–553
Holland HC, Weldon E (1968) A note on a new technique of recording ambulation in the open field test and its validation. Acta Psychol (Amst) 28:293–300
Jorenby D (2002) Clinical efficacy of bupropion in the management of smoking cessation. Drugs 62(Suppl 2):25–35
Lucki I (1997) The forced swimming test as a model for core and component behavioral effects of antidepressant drugs. Behav Pharmacol 8:523–532
Luscombe GP, Martin KF, Hutchins LJ, Gosden J, Heal DJ (1993) Mediation of the antidepressant-like effect of 8-OH-DPAT in mice by post-synaptic 5-HT1A receptors. Br J Pharmacol 108:669–677
Müller WE (2003) Current St. John's wort research from mode of action to clinical efficacy. Pharmacol Res 47:101–109
Nakamura K, Tanaka Y (2001) Antidepressant-like effects of aniracetam in aged rats and its mode of action. Psychopharmacology 158:205–212
Page ME, Detke MJ, Dalvi A, Kirby LG, Lucki I (1999) Serotoninergic mediation of the effects of fluoxetine, but not desipramine in the rat forced swimming test. Psychopharmacology 147:162–167
Pania L, Gessab GL (2002) Dopaminergic deficit and mood disorders. Int Clin Psychopharmacol 17(Suppl 4):1–7
PetitDemouliere B, Chenu F, Bourin M (2005) Forced swimming test in mice: a review of antidepressant activity. Psychopharmacology 177:245–255
Pizzolatti MG, Verdi LG, Brighente IM, Madureira LA, Braz Filho R (2002) Minor gamma-lactones from Trichilia catigua (Meliaceae) and its precursors by GC-MS. Nat Prod Res 18:433–438
Pizzolatti MG, Venson AF, Smania A Jr, Smania Ede F, Braz-Filho R (2004) Two epimeric flavalignans from Trichilia catigua (Meliaceae) with antimicrobial activity. Z Naturforsch 57:483–488
Porsolt RD, Bertin A, Jalfre M (1977a) Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 229:327–336
Porsolt RD, Le Pichon M, Jafre M (1977b) Depression: a new animal model sensitive to antidepressant treatments. Nature 266:730–732
Porsolt RD, Bertin A, Blavet N, Jalfre M (1978) Behavioral despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 47:379–391
Rodrigues AL, da Silva GLO, Mateussi AS, Fernandes ES, Miguel OG, Yunes RA, Calixto JB, Santos ARS (2002) Involvement of monoaminergic system in the antidepressant-like effect of the hydroalcoholic extract of Siphocampylus verticillatus. Life Sci 70:1347–1358
Russig H, Spooren W, Durkin S, Feldon J, Yee BK (2004) Apomorphine-induced disruption of prepulse inhibition that can be normalized by systemic haloperidol is insensitive to clozapine pretreatment. Psychopharmacology 175:143–147
Saddi G, Abbott FV (2000) The formalin test in the mouse: a parametric analysis of scoring properties. Pain 89:53–63
Skolnick P (2002) Beyond monoamine-based therapies: clues to new approaches. J Clin Psychiatry 63:19–23
Skolnick P, Popik P, Janowsky A, Beer B, Lippa AS (2003) “Broad spectrum” antidepressants: is more better for the treatment of depression? Life Sci 73:3175–3179
Stahl SM (1998) Basic psychopharmacology of antidepressants: Part 1. Antidepressants have seven distinct mechanisms of action. J Clin Psychiatry 59(Suppl 4):5–14
Vaz RV, Mata LV, Calixto JB (1997) Analgesic effect of the herbal medicine Catuama in thermal and chemical models of nociception in mice. Phytother Res 11:101–106
Wiley JL, Martin BR (2003) Cannabinoid pharmacological properties common to other centrally acting drugs. Eur J Pharmacol 471:185–193
Yamada J, Sugimoto Y, Yamada S (2004) Involvement of dopamine receptors in the anti-immobility effects of dopamine re-uptake inhibitors in the forced swimming test. Eur J Pharmacol 504:207–211
Yoshitake T, Iizuka R, Yoshitake S, Weikop P, Muller WE, Ogren SO, Kehr J (2004) Hypericum perforatum L (St John's wort) preferentially increases extracellular dopamine levels in the rat prefrontal cortex. Br J Pharmacol 42:414–418
This work was supported by grants from CNPq, CAPES, PRONEX and Laboratório Catarinense (Brazil). E.S.F and J.F. are Ph.D. students receiving grants from CAPES and CNPq, respectively. M.M.C. holds a postdoctoral fellowship from CAPES. The technical assistance of Ms. Aline Mariana Venâncio is gratefully acknowledged.
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Campos, M.M., Fernandes, E.S., Ferreira, J. et al. Antidepressant-like effects of Trichilia catigua (Catuaba) extract: evidence for dopaminergic-mediated mechanisms. Psychopharmacology 182, 45–53 (2005). https://doi.org/10.1007/s00213-005-0052-1
- Trichilia catigua
- Monoamine uptake and release