Skip to main content
SpringerLink
Log in

Tyrosine depletion does not cause depressive relapse in antidepressant-treated patients

  • Letter to the editors
  • Published:
Psychopharmacology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Ainsworth K, Smith SE, Zetterström TSC, Pei Q, Franklin M, Sharp T (1998) Effect of antidepressant drugs on dopamine D1 and D2 receptor expression and dopamine release in the nucleus accumbens of the rat. Psychopharmacology 140:470–477

    Article  CAS  PubMed  Google Scholar 

  • Booij L, Van der Does W, Benkelfat C, Bremner JD, Cowen PJ, Fava M et al (2002) Predictors of mood response to acute tryptophan depletion: a reanalysis. Neuropsychopharmacology 27:852–861

    Article  CAS  PubMed  Google Scholar 

  • Booij L, Van der Does AJW, Riedel WJ (2003) Monoamine depletion in psychiatric and healthy populations: review. Mol Psychiatry 8:951–973

    Article  CAS  PubMed  Google Scholar 

  • Fernstrom MH, Fernstrom JD (1995) Acute tyrosine depletion reduces tyrosine hydroxylation in rat central nervous system. Life Sci 57:97–102

    Article  CAS  Google Scholar 

  • Frank E, Prien RF, Jarrett RB, Keller MB, Kupfer DJ, Lavori PW, Rush AJ, Weissman MM (1992) Conceptualization and rationale for consensus definitions of terms in major depressive disorder. Remission, recovery, relapse and recurrence. Arch Gen Psychiatry 48: 851–855

    Google Scholar 

  • Furst P, Pollack TA, Graser H, Godel H, Stehle P (1990) Appraisal of four precolumn derivatization methods for the high-performance liquid chromatographic determination of free amino acids in biological materials. J Chromatogr 499:557–569

    Article  CAS  PubMed  Google Scholar 

  • Harmer CJ, McTavish SFB, Clark L, Goodwin GM, Cowen PJ (2001) Tyrosine depletion attenuates dopamine function in healthy volunteers. Psychopharmacology 154:105–111

    Article  CAS  PubMed  Google Scholar 

  • Lammers CH, Diaz J, Schwartz JC, Sokoloff P (2000) Selective increase of dopamine D3 receptor gene expression as a common effect of chronic antidepressant treatments. Mol Psychiatry 5:378–388

    Article  CAS  PubMed  Google Scholar 

  • Le Masurier M, Cowen PJ, Sharp T (2004) Fos immunocytochemical studies on the neuroanatomical sites of action of acute tyrosine depletion in the rat brain. Psychopharmacology 171:435–440

    Article  PubMed  Google Scholar 

  • McTavish SFB, Cowen PJ, Sharp T (1999) Effect of a tyrosine-free amino acid mixture on regional brain catecholamine synthesis and release. Psychopharmacology 141:182–188

    Article  CAS  PubMed  Google Scholar 

  • Miller HL, Delgado PL, Salomon RM, Berman R, Krystal JH, Heninger GR, Charney DS (1996) Clinical and biochemical effects of catecholamine depletion on antidepressant-induced remission of depression. Arch Gen Psychiatry 53:117–128

    CAS  PubMed  Google Scholar 

  • Sheehan BD, Tharyan P, McTavish SFB, Campling GM, Cowen PJ (1996) Use of dietary manipulation to deplete plasma tyrosine and phenylalanine in healthy subjects. J Psychopharmacol 10(3):231–234

    CAS  Google Scholar 

  • Smith KA, Fairburn CG, Cowen PJ (1997) Relapse of depression after rapid depletion of tryptophan. Lancet 349:915–919

    Article  CAS  PubMed  Google Scholar 

  • Williamson DJ, McTavish SF, Park SB, Cowen PJ (1995) Effect of valine on 5-HT mediated prolactin release in healthy volunteers and on mood in remitted depressed patients. Br J Psychiatry 167:238–242

    CAS  PubMed  Google Scholar 

  • Wilner P (1995) Dopaminergic mechanisms in depression and mania. In: Kupfer DJ (ed) Psychopharmacology: The Fourth Generation of Progress, Raven, New York, pp 921–931

Download references

Acknowledgements

We thank Alison Reed and John Odontiadis for technical assistance. The study was supported by a clinician scientist award to SFB McT. PJC is an MRC Clinical Scientist.

Author information

Authors and Affiliations

  1. University Department of Psychiatry, Warneford Hospital, Oxford, OX3 7JX, UK

    S. F. B. Mctavish, Z. N. Mannie & P. J. Cowen

Authors
  1. S. F. B. Mctavish
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Z. N. Mannie
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. J. Cowen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P. J. Cowen.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mctavish, S.F.B., Mannie, Z.N. & Cowen, P.J. Tyrosine depletion does not cause depressive relapse in antidepressant-treated patients. Psychopharmacology 175, 124–126 (2004). https://doi.org/10.1007/s00213-004-1945-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00213-004-1945-0

Keywords

Search

Navigation