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Amphetamine increases schedule-induced drinking reduced by negative punishment procedures

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Abstract

Rationale

d-Amphetamine has been reported to increase schedule-induced drinking punished by lick-dependent signalled delays in food delivery. This might reflect a drug-behaviour interaction dependent on the type of punisher, because no such effect has been found when drinking was reduced by lick-contingent electric shocks. However, the anti-punishment effect of amphetamine could be mediated by other behavioural processes, such as a loss of discriminative control or an increase in the value of delayed reinforcers.

Objectives

To test the effects of d-amphetamine on the acquisition and maintenance of schedule-induced drinking reduced by unsignalled delays in food delivery.

Methods

Rats received 10-s unsignalled delays initiated by each lick after polydipsia was induced by a fixed-time 30-s food reinforcement schedule or from the outset of the experiment. Yoked-control rats received these same delays but independently of their own behaviour. d-Amphetamine (0.1–3.0 mg/kg) was then tested IP.

Results

d-Amphetamine dose-dependently increased and then decreased punished schedule-induced drinking. The drug led to dose-dependent reductions when the delays were not contingent or when they were applied from the outset of training.

Conclusions

These results support the contention that d-amphetamine has an increasing effect on schedule-induced drinking that has been previously reduced by a negative punishment procedure. This effect cannot be attributed to other potentially involved processes, and therefore support the idea that drug effects on punished behaviour depend on punishment being delays in food or shock deliveries.

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Acknowledgements

The research was funded by grant PB98-0010-C02-01 from Dirección General de Enseñanza Superior e Investigación Científica, Ministerio de Educación y Cultura, Spain (Ricardo Pellón, Principal Investigator). d-Amphetamine was supplied by Servicio de Restricción de Estupefacientes (Ministerio de Sanidad y Consumo, Madrid, Spain). We thank M.A. Villajos for technical support.

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Authors and Affiliations

  1. Facultad de Psicología, Universidad Nacional de Educación a Distancia, Ciudad Universitaria, 28040, Madrid, Spain

    Ángeles Pérez-Padilla & Ricardo Pellón

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  1. Ángeles Pérez-Padilla
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  2. Ricardo Pellón
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Correspondence to Ricardo Pellón.

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Pérez-Padilla, Á., Pellón, R. Amphetamine increases schedule-induced drinking reduced by negative punishment procedures. Psychopharmacology 167, 123–129 (2003). https://doi.org/10.1007/s00213-002-1382-x

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