Psychopharmacology

, Volume 166, Issue 1, pp 86–90 | Cite as

The delivery rate of dietary carbohydrates affects cognitive performance in both rats and humans

  • David Benton
  • Marie-Pierre Ruffin
  • Taous Lassel
  • Samantha Nabb
  • Michaël Messaoudi
  • Sophie Vinoy
  • Didier Desor
  • Vincent Lang
Original Investigation

Abstract

Rationale.

Glucose is the main metabolic fuel of the brain. The rate of glucose delivery from food to the bloodstream depends on the nature of carbohydrates in the diet, which can be summarized as the glycaemic index (GI).

Objectives.

To assess the benefit of a low versus high GI breakfast on cognitive performances within the following 4 h.

Methods.

The influence of the GI of the breakfast on verbal memory of young adults was measured throughout the morning in parallel to the assessment of blood glucose levels. The learning abilities of rats performing an operant-conditioning test 3 h after a breakfast-like meal of various GI was also examined.

Results.

A low GI rather than high GI diet improved memory in humans, especially in the late morning (150 and 210 min after breakfast). Similarly, rats displayed better learning performance 180 min after they were fed with a low rather than high GI diet.

Conclusion.

Although performances appeared to be only remotely related to blood glucose, our data provide evidence that a low GI breakfast allows better cognitive performances later in the morning.

Keywords.

Breakfast Glucose response Glycaemic index Learning Memory 

References

  1. Benthem L, Bolhuis JW, van der LJ, Steffens AB, Zock JP, Zijlstra WG (1994) Methods for measurement of energy expenditure and substrate concentrations in swimming rats. Physiol Behav 56:151–159PubMedGoogle Scholar
  2. Benton D, Owens DS (1993) Blood glucose and human memory. Psychopharmacology 113:83–88PubMedGoogle Scholar
  3. Benton D, Parker PY (1998) Breakfast, blood glucose, and cognition. Am J Clin Nutr 67:772S–778SPubMedGoogle Scholar
  4. Benton D, Sargent J (1992) Breakfast, blood glucose and memory. Biol Psychol 33:207–210CrossRefPubMedGoogle Scholar
  5. Donohoe RT, Benton D (1999) Cognitive functioning is susceptible to the level of blood glucose. Psychopharmacology 145:378–385PubMedGoogle Scholar
  6. Englyst KN, Englyst HN, Hudson GJ, Cole TJ, Cummings JH (1999) Rapidly available glucose in foods: an in vitro measurement that reflects the glycemic response. Am J Clin Nutr 69:448–454PubMedGoogle Scholar
  7. Englyst KN, Hudson GJ, Englyst HN (2000) Encyclopaedia of analytical chemistry. Wiley, New York, pp 4246–4262Google Scholar
  8. Englyst KN, Vinoy S, Englyst HN, Lang V (2002) Rapidly and slowly available glucose: physicochemical measures that describe the glycaemic index of cereal products. Br J Nutr (in press)Google Scholar
  9. Flood JF, Morley JE (1989) Cholecystokinin receptors mediate enhanced memory retention produced by feeding and gastrointestinal peptides. Peptides 10:809–813PubMedGoogle Scholar
  10. Flood JF, Morley JE (1992) Differential effects of amylin on memory processing using peripheral and central routes of administration. Peptides 13:577–580PubMedGoogle Scholar
  11. Foster-Powell K, Hoft SHA, Brand-Miller JC (2002) International tables of glycemic index and glycemic load values: 2002. Am J Clin Nutr 76:5–56PubMedGoogle Scholar
  12. Foster-Powell K, Miller JB (1995) International tables of glycemic index. Am J Clin Nutr 62:871S–890SPubMedGoogle Scholar
  13. Gispen WH, Biessels G-J (2000) Cognition and synaptic plasticity in diabetes mellitus. Trends Neurosci 23:542–549PubMedGoogle Scholar
  14. Geisler MW, Polich J (1992) P300, food consumption, and memory performance. Psychophysiology 29:76–85PubMedGoogle Scholar
  15. Gold PE (1991) An integrated memory regulation system: from blood to brain. In: Frederickson RCA, McGaugh JL, Felton DL (eds) Peripheral signaling of the brain. Hogrefe and Huber, New York, pp 391–419Google Scholar
  16. Jenkins DJ, Wolever TM, Taylor RH, Barker H, Fielden H, Baldwin JM, Bowling AC, Newman HC, Jenkins AL, Goff DV (1981) Glycemic index of foods: a physiological basis for carbohydrates exchange. Am J Clin Nutr 34:362–366PubMedGoogle Scholar
  17. Kaplan RJ, Greenwood CE, Winocur G, Wolever TM (2001) Dietary protein, carbohydrate, and fat enhance memory performance in the healthy elderly. Am J Clin Nutr 74:687–693PubMedGoogle Scholar
  18. Kaplan RJ, Greenwood CE, Winocur G, Wolever TM (2002) Cognitive performance is associated with glucose regulation in healthy elderly persons and can be enhanced with glucose and carbohydrates. Am J Clin Nutr 72:825–836Google Scholar
  19. Ludwig DS (2002) The glycemic index physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. JAMA 287:2414–2423PubMedGoogle Scholar
  20. Messaoudi M, Tricoire A, Lalonde R, Canini F, Minn A (1996) Effects of MPTP on lever-pressing for light extinction in rats. Eur J Pharmacol 299:17–20CrossRefPubMedGoogle Scholar
  21. Messier C, Destrade C (1988) Improvement of memory for an operant response by post-training glucose in mice. Behav Brain Res 31:185–191PubMedGoogle Scholar
  22. Morley JE, Flood J, Silver AJ (1992) Effects of peripheral hormones on memory and ingestive behaviors. Psychoneuroendocrinology 17:391–399PubMedGoogle Scholar
  23. Park CR (2001) Cognitive effects of insulin in the central nervous system. Neurosci Biobehav Rev 25:311–323CrossRefPubMedGoogle Scholar
  24. Park CR, Seeley RJ, Craft S, Woods SC (2000) Intracerebroventricular insulin enhances memory in a passive-avoidance task. Physiol Behav 68:509–514CrossRefPubMedGoogle Scholar
  25. Smith A, Kendrick A, Maben A, Salmon J (1994) Effects of breakfast and caffeine on cognitive performance, mood and cardiovascular functioning. Appetite 22:39–55PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • David Benton
    • 1
  • Marie-Pierre Ruffin
    • 2
  • Taous Lassel
    • 2
  • Samantha Nabb
    • 1
  • Michaël Messaoudi
    • 4
  • Sophie Vinoy
    • 2
  • Didier Desor
    • 3
  • Vincent Lang
    • 2
  1. 1.Department of PsychologyUniversity of Wales SwanseaSwanseaUK
  2. 2.NutrivaleurDanone VitapolePalaiseau CedexFrance
  3. 3.Biology and Physiology of Behavior LaboratoryFaculty of Sciences, University of Nancy I Vandoeuvre les Nancy CedexFrance
  4. 4.ETAP Ethopharmacology and NutritionVandoeuvre les NancyFrance

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