Abstract
Rationale. Flesinoxan is a highly potent and selective 5-HT1A agonist and appears to be a potentially interesting neuroendocrine serotonergic probe.
Objectives. We assessed hormonal (ACTH, cortisol, prolactin and growth hormone) and temperature responses to flesinoxan in normal volunteers.
Methods. In a double-blind placebo-controlled study, single doses of 0.5 mg and 1 mg were injected over 10 min into 12 healthy male volunteers at 1-week intervals. Temperature and hormonal responses were measured at times –30, 0, 15, 30, 60, 90, and 120 min.
Results. Flesinoxan induced a significant and dose-dependent increase in adrenocorticotropic hormone (ACTH), cortisol, prolactin (PRL), growth hormone (GH) and a decrease in body temperature. Tolerance to flesinoxan was excellent.
Conclusions. These results showed the role of 5-HT1A mechanisms in the PRL, ACTH, cortisol, GH, and temperature responses to flesinoxan. In the present study, flesinoxan appears a very promising serotonergic neuroendocrine probe.
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Pitchot, W., Wauthy, J., Hansenne, M. et al. Hormonal and temperature responses to the 5-HT1A receptor agonist flesinoxan in normal volunteers. Psychopharmacology 164, 27–32 (2002). https://doi.org/10.1007/s00213-002-1177-0
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DOI: https://doi.org/10.1007/s00213-002-1177-0