Advertisement

Psychopharmacology

, Volume 164, Issue 3, pp 294–300 | Cite as

St John's wort extract (LI 160) in somatoform disorders: results of a placebo-controlled trial

  • Hans-Peter Volz
  • Harald Murck
  • Siegfried Kasper
  • Hans-Jürgen Möller
Original Investigation

Abstract

Rationale and objective. Preliminary data have shown that St John's wort might possess some specific efficacy in patients with somatoform complaints. Therefore, the efficacy of the Hypericum extract LI 160 in patients with somatoform disorders should be studied in a double-blind placebo-controlled fashion.

Methods. This was a multicentre, randomised, placebo controlled, 6-week trial comparing the efficacy of LI 160 (600 mg/day) and placebo in 151 out-patients suffering from somatization disorder (ICD-10: F45.0), undifferentiated somatoform disorder (F45.1), or somatoform autonomic dysfunctions (F45.3). The primary outcome measure was the decrease of the Hamilton Anxiety Scale, subfactor somatic anxiety (HAMA-SOM), during the trial period.

Results. LI 160 was superior effective concerning the primary outcome criterion HAMA-SOM [decrease from 15.39 (SD 2.68) to 6.64 (4.32) in the Hypericum group and from 15.55 (2.94) to 11.97 (5.58) in the placebo group (statistically significant difference, P=0.001)]. This was corroborated by the result of a statistically significant superior efficacy in the outcome criteria additionally used such as Clinical Global Impression, HAMA-total score, HAMA, subscore psychic anxiety, Hamilton Depression Scale, Self-Report Symptom Inventory 90 items – revised (SCL-90-R), and SCL-90-R, subscore somatic anxiety. The efficacy of LI 160 was preserved after splitting the population in those with mild and those with severe depressive symptoms. Tolerability of LI 160 was excellent.

Conclusion. The data from this trial show excellent efficacy and tolerability for LI 160 in somatoform disorders. The efficacy is independent of an existing depressive mood. This is the first study showing the efficacy of a drug in patients with somatisation disorder independent of depressive symptomatology.

Somatoform disorders St John's wort LI 160 Placebo-controlled double blind trial Efficacy Safety 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Hans-Peter Volz
    • 1
  • Harald Murck
    • 2
  • Siegfried Kasper
    • 3
  • Hans-Jürgen Möller
    • 4
  1. 1.Krankenhaus für Psychiatrie und Psychotherapie Schloß Werneck, Balthasar-Neumann-Platz 1, 97440 Werneck, Germany
  2. 2.Lichtwer Pharma AG, Berlin, Germany
  3. 3.Psychiatric Department, University of Vienna, Vienna, Austria
  4. 4.Psychiatric Department, University of Munich, Munich, Germany

Personalised recommendations